Medical coating powder containing nano material

A nanomaterial and coating powder technology, which is applied to non-active ingredients medical preparations, sugar-coated pills, pharmaceutical formulations, etc. Problems such as poor physical and chemical parameters, to achieve the effects of wide application, good product stability and long storage period

Inactive Publication Date: 2006-09-20
GUANGDONG GUOFANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned publications have reported some coating materials and coating compositions. We have learned that many organic substances can be used as film-forming agents for coating materials, such as pyrrolidone polymers, hypromellose, etc., but many pharmaceutical coatings The powder composition still has poor comprehensive physical and chemical parameters; some coating materials and coating compositions reported in some open literature are only set for a single variety, and the applicability is not wide, and the coating performance cannot meet the requirements of the coating of traditional Chinese medicine solid preparations. Complex and changeable application needs, and there is no need to add nano-materials to the composition to make a pharmaceutical coating powder containing nano-materials with superior performance in all aspects and a wide range of applications for the complex properties of traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) get 5 kilograms of nanoscale titanium dioxide; (2) take by weighing 60 kilograms of hypromellose, 8 kilograms of vinylpyrrolidone and vinyl acetate copolymer (PVP / VA), 4 kilograms of red coloring agent; (3 ) Put the above-mentioned raw materials in a mixer and stir for 20 minutes to make them fully mixed evenly, add 15 kg of glycerin and 8 kg of pans, and mix for 25 minutes to obtain a uniform mixture; (4) place the above-mentioned mixture in a desiccator Dry at 60-80°C for 3-4 hours; (5) Take out the dried mixture, let it cool and then crush it; (6) Sieve at 60-80 mesh to get the finished product—a dried nano-material pharmaceutical coating powder.

Embodiment 2

[0037] (1) get 2 kilograms of nanoscale titanium dioxide; (2) take by weighing 65 kilograms of hypromellose, 8 kilograms of polyvinylpyrrolidone, 8 kilograms of polyethylene glycol, 2 kilograms of fruit green pigment; (3) mix the above Put the raw materials in a mixer and stir for 20 minutes to make them fully mixed evenly, add 7 kg of glycerin and 8 kg of Span, and mix for 25 minutes to obtain a uniform mixture; (4) place the above mixture in a desiccator for 60 ~ Dry at 80°C for 3 to 4 hours; (5) Take out the dried mixture, let it cool and then pulverize it; (6) Sieve at 60-80 mesh to obtain the finished product—a dried medicinal product containing nanomaterials Coating powder.

Embodiment 3

[0039] (1) get 10 kilograms of nano-scale titanium dioxide; (2) take by weighing 60 kilograms of hypromellose, 8 kilograms of polyvinyl alcohol, and 4 kilograms of yellow colorant; (3) place the above-mentioned raw materials in a mixer and stir for 20 10 minutes, make it fully mix uniformly, add 10 kilograms of glycerin, 8 kilograms of Tween, mix 25 minutes, obtain uniform mixture; (4) above-mentioned mixture is placed in desiccator 60~80 ℃ and dry 3~4 hours; (5) Take out the dried mixed material, let it cool down and then pulverize it; (6) obtain the finished product through screening at 60-80 meshes——dried pharmaceutical coating powder containing nanomaterials.

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PUM

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Abstract

The medicinal coating powder containing nanometer material consists of hydromellose 55-65 wt%, copolymer of vinyl pyrrolidone and vinyl acetate 8 wt%, glycerin 15 wt%, Span 8 wt%, coloring agent 2-4 wt%, and nanometer titania 2-10 wt%. The medicinal coating powder containing nanometer material has simple production process, wide application, high performance / cost ratio, no physiological toxicity and many other advantages, and may meet the requirement of coating various solid Chinese medicine preparation.

Description

technical field [0001] The invention relates to a pharmaceutical coating powder and a production process thereof, in particular to a pharmaceutical coating powder containing nanometer materials. technical background [0002] In the prior art, in order to make the solid preparations of medicines (such as tablets, pills, etc.) visually aesthetically pleasing, have better storage stability in preservation, and have better solubility in the gastrointestinal tract, so that it is convenient Taking it, it is often necessary to wrap suitable materials on its surface, which is usually called the coating of the preparation. For many years, domestic pharmaceutical companies, especially the pharmaceutical companies that mainly produce traditional Chinese medicines, have generally used sugar coating. The operation process is complicated and lengthy, and the technology is difficult to master. And the storage stability of the finished product is poor, and the quality is difficult to guara...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K9/28
Inventor 刘瑞驹杨传生张志武
Owner GUANGDONG GUOFANG MEDICAL TECH
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