Cephalosporin compound

Abstract

The invention relates to a novel cephalosporin compound with a general formula (I), pharmaceutically acceptable salt(s) thereof, easy hydrolysable ester(s) thereof, isomer(s) thereof, hydrate(s) thereof, and hydrate(s) of the salt(s) or ester(s) thereof, wherein, R <1>, R<2>, R<3>, R<4>, R<5> and X are defined in the specification. The invention also relates to preparation methods of these compounds, the medicine compositions containing these compounds, and applications of these compounds in preparing medicines for treatment and / or prevention of infective diseases, pertaining to medicine technique field.

Description

Novel cephalosporin compounds 1. Technical field The present invention relates to a novel cephalosporin compound, its pharmaceutically acceptable salt, its easily hydrolyzable ester, its isomer, its hydrate and its salt or ester hydrate, the preparation method of these compounds, containing these The pharmaceutical compositions of the compounds and the use of these compounds in the preparation of medicines for the treatment and / or prevention of infectious diseases belong to the technical field of medicine. 2. Background technology Cephalosporin antibiotics are widely used in clinical antibacterial drugs and have developed into the fourth generation. However, due to long-term clinical application, bacteria are resistant to cephalosporin antibiotics, which greatly affects the antibacterial efficacy of cephalosporin antibiotics. its clinical application. In particular, infectious diseases caused by methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococc...

AI Technical Summary

Problems solved by technology

Cefepime hydrochloride is a fourth-generation cephalosporin with a broad antibacterial spectrum, strong antibacterial effect, and good antibacterial activity against Gram-negative bacteria. However, its effect on clinically isolated strains is not satisfactory. The structural formula is as follows:

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