Dihydropyrrole methano substituted carbapenem derivates

Abstract

The invention pertains to the technical field of medicine and particularly relates to a carbon-substituted penem derivative which contains dihydro pyrrole methylene substitution and is shown as general formula (I), and pharmaceutically acceptable salts, easily hydrolysable ester and isomers of the derivative; wherein, R<1>, R<2> and R<3> are defined as the specification. The invention also relates to a preparation method of the compounds, medicine composition containing the compounds as well as application of the compounds to the preparation of medicines treating and / or preventing infectious diseases.

Description

1. Technical field The invention belongs to the technical field of medicine, in particular to carbapenem derivatives substituted with dihydropyrromethene groups, pharmaceutically acceptable salts thereof, easily hydrolyzed esters and isomers thereof, and methods for preparing these compounds , a pharmaceutical composition containing these compounds, and the use of these compounds in the preparation of medicines for treating and / or preventing infectious diseases. 2. Background technology Carbapenem antibiotics are a class of β-lactam antibiotics developed in the 1970s. It has attracted much attention because of its broad antibacterial spectrum, strong antibacterial activity, and stability to β-lactamase. Its structural feature is that the sulfur at the 1-position of the penicillane core is replaced by carbon, and the 2-position has a double bond, which combines the five-membered ring of penicillin and the conjugated double bond of cephalosporin to activate the β-lactam ring....

AI Technical Summary

Problems solved by technology

Bacterial drug resistance is increasing due to the abuse of antibiotics, and the half-life is short except for ertapenem, which can no longer meet the clinical needs

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