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Penem derivant containing adamantane

A technology of drugs and alkyl groups, applied in the field of medicine, can solve the problems of low clinical availability and short half-life.

Active Publication Date: 2010-12-15
XUANZHU BIOPHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the continuous increase of bacterial resistance due to the abuse of antibiotics and the limitation of digestive tract absorption, the currently marketed carbapenems can only be administered as injections in clinical practice, and the clinical utilization is not high. The half-life of penem is relatively short, which can no longer meet the clinical needs

Method used

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  • Penem derivant containing adamantane
  • Penem derivant containing adamantane
  • Penem derivant containing adamantane

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Abstract

The present invention belongs to the technical field of medicine, and in particular relates to a penem derivative containing Adamantanes as shown in Formula (I), acceptable salt thereof in pharmacy, easily hydrolyzed ester thereof, isomer thereof, hydrate thereof, and hydrate of ester or salt thereof; wherein, R<1>, R<2>, R<3> and R<4> are defined as in the specification. The present invention also relates to the preparation methods of the compounds, drug compositions of the compounds, and application of the compounds in preparation of medicine which is used for treating and / or preventing infectious diseases.

Description

1. Technical field The invention belongs to the technical field of medicine, and specifically relates to penem derivatives containing adamantane, pharmaceutically acceptable salts thereof, easily hydrolyzed esters, isomers thereof, hydrates thereof, and hydrates of esters or salts thereof. The preparation method of these compounds, the pharmaceutical composition containing these compounds, and the use of these compounds in the preparation of medicines for treating and / or preventing infectious diseases. 2. Background technology Carbapenem antibiotics are a class of β-lactam antibiotics developed in the 1970s. It has attracted much attention because of its broad antibacterial spectrum, strong antibacterial activity, and stability to β-lactamase. Its structural feature is that the sulfur at the 1-position of the penicillane core is replaced by carbon, and the 2-position has a double bond, which combines the five-membered ring of penicillin and the conjugated double bond of cep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D477/20A61K31/407A61P31/00
Inventor 黄振华
Owner XUANZHU BIOPHARMACEUTICAL CO LTD
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