Carbapenem derivative containing guanidyl alkanoylamino heterocycle
An azabicycle and methyl technology, which can be used in medical preparations containing active ingredients, organic chemistry, organic active ingredients, etc., can solve the problems of increased drug resistance and low clinical availability.
Active Publication Date: 2011-01-12
XUANZHU BIOPHARMACEUTICAL CO LTD
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Problems solved by technology
The clinical efficacy of carbapenem antibiotics is excellent, but with the increase of clinical application, drug resistance increases, and the currently marketed penem antibiotics can only be administered as injections in clinical practice, and the clinical utilization is not high
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The invention belongs to the technical field of medicine, and in particular relates to a carbapenem derivative containing guanidyl alkane amido heterocycle as shown in the general formula (I), a pharmaceutically acceptable salt thereof, and an easily-hydrolytic ester thereof or an isomer thereof, wherein R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7>, R<8> and X are as defined in the instruction. The invention also relates to a method for preparing the compounds, a pharmaceutical composition containing the compounds, as well as application of the compounds in the preparation of drugs for treating and / or preventing infectious diseases.
Description
1. Technical field The invention belongs to the field of medical technology, and in particular relates to carbapenem derivatives containing a guanidinoalkanoyl amido heterocycle, pharmaceutically acceptable salts thereof, easily hydrolyzed esters or isomers thereof, and methods for preparing these compounds. A pharmaceutical composition containing these compounds, and the application of these compounds in the preparation of medicines for treating and / or preventing infectious diseases. 2. Background technology Carbapenem antibiotics are new broad-spectrum, enzyme-resistant and highly effective β-lactam antibiotics developed in the 1970s. In 1976, Thiamycin, the first carbapenem antibiotic, was discovered, but it was not used clinically due to its poor chemical stability. Later, the chemical structure modification of thiamycin produced a series of carbapenem derivatives. Drugs of this type currently on the market include imipenem, panipenem, meropenem, doripenem, biapenem, a...
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IPC IPC(8): C07D477/20A61K31/427A61K31/433A61P31/04
CPCY02P20/55
Inventor 黄振华
Owner XUANZHU BIOPHARMACEUTICAL CO LTD
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