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Bismuth selenide nanocomposite material and preparation method and application thereof

A technology of nanocomposite material and bismuth selenide is applied in the field of nanomaterials to achieve the effects of improving body immunity, improving biocompatibility and improving immunity

Active Publication Date: 2017-05-24
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] It can be seen that some reports on bismuth selenide nanomaterials in recent years only involve its application in tumor treatment and imaging, but there are few reports on bismuth selenide nanomaterials used to reduce the side effects of radiotherapy

Method used

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  • Bismuth selenide nanocomposite material and preparation method and application thereof
  • Bismuth selenide nanocomposite material and preparation method and application thereof
  • Bismuth selenide nanocomposite material and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0073] (1) Mix 0.5 mL of 0.5 mol / L NaOH aqueous solution with 10 mL of 1 mg / mL selenocystine aqueous solution to dissolve the solid completely to obtain Solution I;

[0074] (2) Bi(NO 3 ) 3 ·5H 2 O was dissolved in ethylene glycol, and ultrasonically dissolved to obtain solution II, in which Bi(NO 3 ) 3 ·5H 2 The concentration of O is 0.1mol / L;

[0075] (3) Under the protection of argon gas, add 19.5mL deionized water into the three-necked flask, dissolve 1g of 10KD polyvinylpyrrolidone into it, stir evenly, and heat up to 75°C to obtain reaction system A;

[0076] (4) Solution I was quickly added to reaction system A at one time, and stirred rapidly for 10 minutes to obtain reaction system B;

[0077] (5) The solution II was quickly added to the reaction system B at one time, stirred rapidly, and kept for 2 hours for reaction to obtain the reaction system C;

[0078] (6) Cool reaction system C to room temperature, transfer system C to a centrifuge tube, centrifuge at 2...

Embodiment 2

[0094] (1) Mix 0.6 mL of 0.1 mol / L KOH aqueous solution and 10 mL of 0.5 mg / mL selenocystine aqueous solution to dissolve the solid completely to obtain Solution I;

[0095] (2) Bi(NO 3 ) 3 ·5H 2 O was dissolved in ethylene glycol, and ultrasonically dissolved to obtain solution II; Bi(NO 3 ) 3 ·5H 2 The concentration of O dissolved in ethylene glycol is 0.05mol / L;

[0096] (3) Add 19.4 mL of deionized water into the three-necked flask, dissolve 0.50000 g of 10KD polyvinylpyrrolidone into it, stir evenly, and at the same time pass through argon gas protection, and heat up to 80°C to obtain reaction system A;

[0097] (4) Solution I was quickly added to reaction system A at one time, and stirred rapidly for 8 minutes to obtain reaction system B;

[0098] (5) The solution II was quickly added to the reaction system B at one time, stirred rapidly, and kept for 3 hours to react to obtain the reaction system C;

[0099] (6) Cool reaction system C to room temperature, transfe...

Embodiment 3

[0101] (1) Mix 1mL of 1mol / L NaOH aqueous solution with 15mL of 1.5mg / mL selenocystine aqueous solution to dissolve the solid completely to obtain Solution I;

[0102] (2) Bi(NO 3 ) 3 ·5H 2 O was dissolved in ethylene glycol, and ultrasonically dissolved to obtain solution II; Bi(NO 3 ) 3 ·5H 2 The concentration of O dissolved in ethylene glycol is 2mol / L;

[0103] (3) Add 19.4mL of deionized water into the three-necked flask, dissolve 2.0000g of 10KD polyvinylpyrrolidone into it, stir evenly, and at the same time pass through argon gas protection, and heat up to 75°C to obtain reaction system A;

[0104] (4) Solution I was quickly added to reaction system A at one time, and stirred rapidly for 10 minutes to obtain reaction system B;

[0105] (5) The solution II was quickly added to the reaction system B at one time, stirred rapidly, and kept for 2 hours for reaction to obtain the reaction system C;

[0106] (6) Cool reaction system C to room temperature, transfer syste...

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Abstract

The invention provides a bismuth selenide nanocomposite material and a preparation method and application thereof. The bismuth selenide nanocomposite material comprises polyvinylpyrrolidone, selenocysteine, and bismuth selenide coated by the polyvinylpyrrolidone and the selenocysteine. The bismuth selenide nanocomposite material has a good light-heat conversion function, can achieve effective combination of thermotherapy and radiotherapy to play a synergistic effect, and can overcome respective defects of the two therapy methods to obtain the optimal tumor treatment effect; after completion of the radiotherapy, the selenocysteine is degraded from the surface of the material and can effectively enter a living body to participate in synthesis of selenium protein, so that the body immunity is enhanced, and the side effects caused by the radiotherapy are reduced.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a bismuth selenide nanocomposite material and a preparation method and application thereof. Background technique [0002] In the past few decades, despite the increasing awareness of cancer, cancer is still one of the leading causes of human death worldwide. Radiation therapy is one of the three main methods of tumor treatment, and it is widely used in the treatment of various tumors. The principle of radiation therapy is to irradiate the local tumor with X-rays or γ-rays, and the water molecules around the tumor will generate oxygen-like free radicals to destroy the DNA double strands, prevent the proliferation of tumor cells, and then kill tumor cells. However, radiotherapy will also cause damage to normal cells at the same time, resulting in serious radiation side effects, such as a decrease in the number of white blood cells and inhibition of bone marrow revascular...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K33/04A61K31/198A61K9/51A61K47/32A61P35/00A61P37/04A61P39/00
CPCA61K9/5138A61K31/198A61K33/04A61K41/0038A61K41/0052A61K2300/00
Inventor 赵宇亮杜江锋晏亮谷战军
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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