Biodegradable medical magnesium alloy as well as preparation method thereof

A biomedical and magnesium alloy technology, applied in the field of biomedical materials, can solve the problems of magnesium matrix cytotoxicity and excessive corrosion, and achieve the effects of improving biocompatibility, increasing nucleation rate, and promoting nucleation.

Active Publication Date: 2014-01-22
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The early clinical application of magnesium as a surgical material has confirmed the feasibility of magnesium for biomedical mat

Method used

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  • Biodegradable medical magnesium alloy as well as preparation method thereof
  • Biodegradable medical magnesium alloy as well as preparation method thereof
  • Biodegradable medical magnesium alloy as well as preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1

[0023] The first step is the preparation of as-cast Mg-1.0wt%Zn-0.2wt%Y-0.5wt%Nd-0.4wt%Zr magnesium alloy (target product)

[0024] Ⅰ Preparation

[0025] The raw materials required for this experiment are:

[0026] High purity magnesium ingot (purity ≥99.9%): 1326g

[0027] High-purity zinc ingot (purity ≥99.9%): 17.7g, in which the content of zinc is 1.25 times that of the obtained magnesium alloy (target product);

[0028] Mg-28.5wt% Y master alloy: 12.5g, in which the content of Y is 1.4 times that of the obtained magnesium alloy (target product);

[0029] Mg-30wt%Nd master alloy: 29.6g, in which the Nd content is 1.3 times that of the obtained magnesium alloy (target product);

[0030] Mg-30wt%Zr master alloy: 47.2g, in which the content of Zr is 2.5 times that of the obtained magnesium alloy (target product);

[0031] In order to prevent the oxidation and combustion of the magnesium alloy, a protective gas has been passed through the entire smelting process. The pr...

Example Embodiment

[0044] Example 2

[0045] The first step is the preparation of as-cast Mg-2.0wt%Zn-0.5wt%Y-0.5wt%Nd-0.4wt%Zr magnesium alloy (target product)

[0046] Ⅰ Preparation

[0047] The raw materials required for this experiment are:

[0048] High purity magnesium ingot (purity ≥99.9%): 1360g

[0049] High-purity zinc ingot (purity ≥99.9%): 37.3g, in which the content of zinc is 1.25 times that of the obtained magnesium alloy (target product);

[0050] Mg-28.5wt% Y master alloy: 32.6g, in which the content of Y is 1.25 times that of the obtained magnesium alloy (target product);

[0051] Mg-30wt% Nd master alloy: 31g, in which the Nd content is 1.25 times that of the obtained magnesium alloy (target product);

[0052] Mg-30wt%Zr master alloy: 49.6g, in which the content of Zr is 2.5 times that of the obtained magnesium alloy (target product);

[0053] In order to prevent the oxidation and combustion of magnesium alloys, a protective gas has been passed through the entire smelting process. The prot...

Example Embodiment

[0066] Example 3

[0067] The first step is the preparation of as-cast Mg-3.0wt%Zn-1.5wt%Y-1.5wt%Nd-0.4wt%Zr magnesium alloy (target product)

[0068] Ⅰ Preparation

[0069] The raw materials required for this experiment are:

[0070] High purity magnesium ingot (purity ≥99.9%): 1280g

[0071] High-purity zinc ingot (purity ≥99.9%): 58.4g, in which the content of zinc is 1.25 times that of the obtained magnesium alloy (target product);

[0072] Mg-28.5wt% Y master alloy: 102.5g, in which the content of Y is 1.25 times that of the obtained magnesium alloy (target product);

[0073] Mg-30wt%Nd master alloy: 97.3g, in which the Nd content is 1.25 times that of the obtained magnesium alloy (target product);

[0074] Mg-30 wt %Zr master alloy: 51.8g, in which the content of Zr is 2.5 times that of the obtained magnesium alloy (target product);

[0075] In order to prevent the oxidation and combustion of magnesium alloys, a protective gas has been passed through the entire smelting process. The ...

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Abstract

The invention discloses a biodegradable medical magnesium alloy which consists of the following matters in percentage by weight: 1.0-3.0% of Zn, 0.20-1.50% of Y, 0.40-1.50% of Nd, 0.30-0.50% of Zr and the balance of Mg and inevitable impurity elements. Meanwhile, the invention discloses a preparation method of the alloy. The magnesium alloy is smelted to prepare common magnesium alloy. The use level of Zn, Y and Nd in furnace burden is 1.2-1.4 times the content of Zn, Y and Nd in the magnesium alloy, and the use level of Zr is 2-2.5 times the content of Zr in the magnesium alloy. According to the invention, the magnesium alloy overcomes the problems of cytotoxicity, excessively high corrosion rate and the like by adding rare earth elements Y, Nd and Zr into a magnesium-zinc alloy, and the potential difference with a matrix is reduced due to a lot of uniformly dispersed and distributed nano MgZn particle phases in the matrix by extrusion and processing, so that the corrosion resistance of the alloy is greatly improved, and the alloy has better mechanical properties.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a degradable biomedical magnesium alloy and a preparation method thereof. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, cardiovascular and cerebrovascular diseases caused by hyperlipidemia and hypertension have become one of the most important diseases that threaten human health. As early as the 20th century, minimally invasive interventional treatment of vascular diseases began to be applied, and was subsequently recognized as one of the most effective means of treating cardiovascular and cerebrovascular diseases; vascular stent implantation emerged as the times require, developed rapidly, and is being widely used in cardiovascular diseases. disease intervention. With the implantation of tiny stents, clinical conditions such as myocardial ischemia and coronary heart disease can b...

Claims

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Application Information

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IPC IPC(8): C22C23/04C22C23/06C22C1/03C22F1/06
Inventor 关绍康季川祥朱世杰王利国马迅岳高超刘茜王剑锋
Owner ZHENGZHOU UNIV
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