KMnF3 nuclear magnetic resonance imaging contrast agent, preparation method and application thereof

Abstract

The invention belongs to the technical field of medical contrast agents, and particularly relates to a KMnF3 nuclear magnetic resonance imaging contrast agent, a preparation method and application thereof. The contrast agent has an extremely high relaxivity (23.15mM.S<-1>) and a low r2 / r1 ratio (3.23), and primary animal nuclear magnetic resonance imaging experiments by using a colloidal solution which is prepared by the method indicate that the contrast agent can be used in contrast enhanced imaging of a mouse brain. Furthermore, the contrast agent can stay in a body for a proper period, and can become a novel medical nuclear magnetic resonance imaging contrast agent.

Description

technical field [0001] The present invention relates to a kind of KMnF 3 Magnetic resonance imaging contrast agent, preparation method and use. Background technique [0002] NMR is a technique that uses the resonance of the hydrogen nuclei of water molecules in body fluids or tissues to image. It is very sensitive to small differences in physicochemical properties of different organs or tissues. In medicine, it is often used to distinguish different tissues and detect diseases that cause changes in physical and chemical properties, such as tumors. Due to the local magnetic field generated by electron spin in some paramagnetic and superparamagnetic particles, the magnetic resonance relaxation time T of its neighboring hydrogen nuclei can be changed 1 and T 2 , and the concentration of these particles is higher where the composition is different, so it is usually used as a contrast agent to improve the contrast of MRI. At present, more researches include superparamagnet...

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Problems solved by technology

At present, more researches include superparamagnetic iron oxide, manganese, gadolinium and other contrast agents, among which superparamagnetic iron oxide is used as T 2 Contrast agents have been clinically used as contrast agents for the liver, but as negative contrast agents, such contrast agents can cause susceptibility artifacts and overlap with signals such as calcification and blood flow in the body, making diagnosis difficult

Therefore, its application is limited; while T 1 Class contrast agents can avoid these problems, the current commercial T 1 Contrast agents mainly contain Gd 3+ contrast agent, although Gd 3+ There are 7 unpaired electrons in the outermost layer, which has a high magnetic moment and is conducive to contrast-enhanced imaging, but Gd 3+ As a heavy metal element, it will cause harm to the human body after entering the human body. In order to solve this problem, Mn with 5 unpaired electrons, strong paramagnetism and low toxicity 2+ Contrast agents began to develop slowly, in which MnCl 2 Has been widely used in the field of imaging to observe the fine structure of the brain and neural activity, but MnCl 2 It will cause damage to the human heart; and by preparing MnO nanoparticles with uniform size and modifying them into composite particles with better biocompatibility, good contrast effects can also be obtained, but at present, the relaxation efficiency of Mn-based contrast agents Generally low, the reason is that Mn in MnO nanoparticles is unstable and easily oxidized to a high valence state

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