KMnF3 nuclear magnetic resonance imaging contrast agent, preparation method and application thereof

A nuclear magnetic resonance imaging and nuclear magnetic resonance technology, which is applied in the directions of pharmaceutical formulations, preparations for in vivo tests, emulsion delivery, etc., can solve the problems of low relaxation efficiency, difficult diagnosis, Mn instability, etc., and achieve high transverse relaxation Efficiency, good application prospect, simple preparation method

Inactive Publication Date: 2014-12-24
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, more researches include superparamagnetic iron oxide, manganese, gadolinium and other contrast agents, among which superparamagnetic iron oxide is used as T 2 Contrast agents have been clinically used as contrast agents for the liver, but as negative contrast agents, such contrast agents can cause susceptibility artifacts and overlap with signals such as calcification and blood flow in the body, making diagnosis difficult
Therefore, its application is limited; while T 1 Class contrast agents can avoid these problems, the current commercial T 1 Contrast agents mainly contain Gd 3+ contrast agent, although Gd 3+ There are 7 unpaired electrons in the outermost layer, which has a high magnetic moment and is conducive to contrast-enhanced imaging, but Gd

Method used

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  • KMnF3 nuclear magnetic resonance imaging contrast agent, preparation method and application thereof
  • KMnF3 nuclear magnetic resonance imaging contrast agent, preparation method and application thereof
  • KMnF3 nuclear magnetic resonance imaging contrast agent, preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0038] Embodiment 1: Weigh 0.3298gMnCl 2 . 4H 2 O, 0.4706gKF . 2H 2 O and 1.0686g of potassium oleate were dissolved in 16ml of absolute ethanol, stirred evenly, transferred to a polytetrafluoroethylene liner and sealed, placed in a stainless steel jacket, tightened and placed in an oven, heated to 160 degrees, and kept for 24 hours. After cooling to room temperature, the liner was taken out, and the product was washed with deionized water and then with absolute ethanol, and then centrifuged to obtain KMnF 3 Nanocrystalline.

Embodiment 2

[0039] Embodiment 2: as figure 1 , 2 , 3, 4, 5, 6, 7, and 8, the reaction product obtained in Example 1 was added to 16ml of absolute ethanol, and then 0.1gPEG-1500 was added for ultrasonic oscillation to disperse evenly and then transferred to a polytetrafluoroethylene inner container Sealed in the middle, placed in a stainless steel jacket, tightened and placed in an oven, heated to 180 degrees, kept warm for 2 hours, cooled to room temperature, then taken out the liner, washed three times with deionized water and then three times with absolute ethanol, and dried at 60 degrees 2 hours.

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Abstract

The invention belongs to the technical field of medical contrast agents, and particularly relates to a KMnF3 nuclear magnetic resonance imaging contrast agent, a preparation method and application thereof. The contrast agent has an extremely high relaxivity (23.15mM.S<-1>) and a low r2/r1 ratio (3.23), and primary animal nuclear magnetic resonance imaging experiments by using a colloidal solution which is prepared by the method indicate that the contrast agent can be used in contrast enhanced imaging of a mouse brain. Furthermore, the contrast agent can stay in a body for a proper period, and can become a novel medical nuclear magnetic resonance imaging contrast agent.

Description

technical field [0001] The present invention relates to a kind of KMnF 3 Magnetic resonance imaging contrast agent, preparation method and use. Background technique [0002] NMR is a technique that uses the resonance of the hydrogen nuclei of water molecules in body fluids or tissues to image. It is very sensitive to small differences in physicochemical properties of different organs or tissues. In medicine, it is often used to distinguish different tissues and detect diseases that cause changes in physical and chemical properties, such as tumors. Due to the local magnetic field generated by electron spin in some paramagnetic and superparamagnetic particles, the magnetic resonance relaxation time T of its neighboring hydrogen nuclei can be changed 1 and T 2 , and the concentration of these particles is higher where the composition is different, so it is usually used as a contrast agent to improve the contrast of MRI. At present, more researches include superparamagnet...

Claims

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Application Information

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IPC IPC(8): A61K49/12A61K49/10A61K49/18
Inventor 唐群刘志军宋小霞朱伟
Owner NANCHANG UNIV
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