Novel fluorescence lipidosome nano probe and preparing method thereof

Abstract

The invention discloses a novel fluorescence lipidosome nano probe. The fluorescence lipidosome nano probe contains water-soluble CdTe quantum dots, dipalmitoyl phosphatidyl choline, cholesterol, polyethylene glycol-distearoyl phosphoethanolamine and folic acid-polyethylene glycol-distearoyl phosphoethanolamine. The fluorescence lipidosome nano probe has the advantages of being good in fluorescence property, target property and stability, and high in biocompatibility.

Description

technical field [0001] The invention belongs to the field of nanotechnology and fluorescence diagnosis research, in particular to a novel fluorescent liposome nanoprobe and a preparation method thereof. Background technique [0002] Fluorescent quantum dots (quantumdots, QDs), also known as semiconductor nanocrystals (semiconductor nanocrystals), refer to spherical semiconductor materials that reach a certain critical size (exciton Bohr radius) in three-dimensional space and have quantum confinement effects. 2 to 10 nm (2000 to 10000 atoms). It is usually composed of II-VI or III-V group elements of the periodic table of elements. At present, CdX (X=S, Se, Te) materials are mainly studied. As a new type of inorganic fluorescent probe, fluorescent quantum dots have many unique properties and can effectively overcome some fatal weaknesses of organic fluorescent dyes and fluorescent proteins. The main performances are as follows: (1) The excitation spectrum of fluorescent qua...

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Problems solved by technology

However, traditional fluorescent dyes require a variety of excitation lights depending on the material, so the accumulated energy can easily damage the test sample, especially the biological sample, and because of its wide emission spectrum and heavy overlap, it is difficult to Realize multi-color labeling and multi-component detection; (3) higher fluorescence efficiency

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