Novel fluorescence lipidosome nano probe and preparing method thereof

A nanoprobe and fluorescent lipid technology, applied in the field of nanotechnology and fluorescence diagnosis research, can solve the problems of difficulty in multi-color labeling and multi-component detection, heavy overlapping phenomenon, wide emission spectrum, etc., and improve tumor targeting. , the effect of improving stability and prolonging cycle time

Inactive Publication Date: 2016-05-04
GUIZHOU MEDICAL UNIV
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Problems solved by technology

However, traditional fluorescent dyes require a variety of excitation lights depending on the material, so the accumulated energy can easily damage the test sample, especially the biologi

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  • Novel fluorescence lipidosome nano probe and preparing method thereof

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[0018] The specific embodiments of the present invention will be further described below in conjunction with the accompanying drawings. It should be noted here that the description of these embodiments is used to help understand the present invention, but does not constitute a limitation to the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other.

[0019] Implement one

[0020] 1. Instruments and reagents

[0021] 1.1 Instrument

[0022] The instrument is a magnetic stirrer; digital display magnetic stirrer; heating jacket; electronic balance; vacuum decompression dryer; freeze dryer.

[0023] 1.2 Test drug

[0024] Folic acid (≥97%); N,N'-dicyclohexylcarbodiimide (DCC99%); DSPE-PEG-NH 2 ; Pyridine; Dimethyl sulfoxide; Sodium chloride; Methanol; Te powder (99%); NaBH 4 (AR grade); Mercaptopropionic acid (AR grade); CdCl 2 ·2.5H ...

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Abstract

The invention discloses a novel fluorescence lipidosome nano probe. The fluorescence lipidosome nano probe contains water-soluble CdTe quantum dots, dipalmitoyl phosphatidyl choline, cholesterol, polyethylene glycol-distearoyl phosphoethanolamine and folic acid-polyethylene glycol-distearoyl phosphoethanolamine. The fluorescence lipidosome nano probe has the advantages of being good in fluorescence property, target property and stability, and high in biocompatibility.

Description

technical field [0001] The invention belongs to the field of nanotechnology and fluorescence diagnosis research, in particular to a novel fluorescent liposome nanoprobe and a preparation method thereof. Background technique [0002] Fluorescent quantum dots (quantumdots, QDs), also known as semiconductor nanocrystals (semiconductor nanocrystals), refer to spherical semiconductor materials that reach a certain critical size (exciton Bohr radius) in three-dimensional space and have quantum confinement effects. 2 to 10 nm (2000 to 10000 atoms). It is usually composed of II-VI or III-V group elements of the periodic table of elements. At present, CdX (X=S, Se, Te) materials are mainly studied. As a new type of inorganic fluorescent probe, fluorescent quantum dots have many unique properties and can effectively overcome some fatal weaknesses of organic fluorescent dyes and fluorescent proteins. The main performances are as follows: (1) The excitation spectrum of fluorescent qua...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/0084A61K49/0067
Inventor 杨畅胡珺王永林郑林兰燕宇李勇军王爱民陈思颖
Owner GUIZHOU MEDICAL UNIV
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