Scaffold material capable of inducing biological hard tissue or soft tissue

A scaffold material and hard tissue technology, used in prostheses, dental implants, coatings, etc., can solve problems such as the inability to meet the osseointegration state, achieve excellent induction and implantation, improve external force, and be easy to manufacture.

Active Publication Date: 2007-10-31
HI-LEX CORPORATION +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, it has been found that the implant material having the above-mentioned geometric structure penetrates into the implant material of osteoblasts, and cannot satisfy the state of osseointegration integrated with the cells.

Method used

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  • Scaffold material capable of inducing biological hard tissue or soft tissue
  • Scaffold material capable of inducing biological hard tissue or soft tissue
  • Scaffold material capable of inducing biological hard tissue or soft tissue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0111] The artificial tooth root 40 shown in Fig. 5 is produced. Here, the internal thread formed on the inner surface of the introduction hole 44 is not formed. The base material 41 is formed by filling a mold with a titanium metal wire with a diameter of 80 μm and sintering it so that the diameter of the flange portion 43 is 4 mm, the diameter of the introduction hole 44 is 2 mm, the length is 3 mm, and the average hole diameter is 80 μm.

[0112] In addition, the cell induction layer 42 is wound with a metal nonwoven fabric formed by entangling titanium metal wires with a diameter of 80 μm so that the average pore diameter is 200 μm.

[0113] Furthermore, a titanium rod was installed in the introduction hole 44, and they were bonded by vacuum sintering to form an artificial tooth root. The base material 41 of the artificial tooth root 40 thus formed corresponds to the bonding layer of the present invention, and the cell-inducing layer 42 corresponds to the metal fiber laye...

Embodiment 2

[0150] A culture chassis in which the titanium fiber mesh of Example 1 was inserted into a bottomed cylindrical titanium frame was produced. Set as Example 2.

[0151] [Comparative example 1]

[0152] A plastic case made of a conventionally known flat plastic dish was used as Comparative Example 1.

[0153] Fibroblasts in Examples 1 and 2 and Comparative Example 1 were seeded, soaked in a culture solution, and cultured for 2 weeks. Fig. 17 shows the amount of collagen produced by fibroblasts at this time. It can be seen from the figure that when cultured with the culture chassis (Example 1) used in the culture method of the present invention, the production of collagen was increased by 1.4 times compared with the usual plastic box. Furthermore, when the culture was carried out in the culture base plate (Example 2) equipped with a rack, the production of collagen was increased by 1.8 times compared with the usual plastic box.

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Abstract

The invention provides an implant material which exhibits relatively high mechanical binding with an osteoblast and also high strength. A scaffold material (10) capable of inducing a biological hard tissue, which comprises a rod (11) having a trunk portion (21) and bride girders (22), a binding layer (13) formed on the periphery of the rod and a metal fiber layer (14) formed on the periphery of the binding layer, and which further has a reinforcing layer (15) formed on the periphery of the metal fiber layer (14). The binding layer (13) has pores having an average pore size of less than 100 [mu]m, and the metal fiber layer (14) has pores having an average pore size of 100 to 400 [mu]m.

Description

technical field [0001] The present invention relates to a kind of body hard tissue or soft tissue inductive bracket material (hereinafter referred to as bracket) used for artificial tooth root implantation, artificial joint implantation, bone fixation support such as bone plate, replacement bone or artificial viscera and its holding device Material). Furthermore, the present invention relates to a method for culturing cells and microorganisms, a method for producing biologically derived substances (especially medical collagen) using the method, and a device used in these methods. Background technique [0002] Patent Document 1: Japanese Unexamined Patent Publication No. 11-341 [0003] Patent Document 2: Japanese Unexamined Patent Publication No. 8-140996 [0004] Patent Document 3: JP-A-2004-67547 [0005] Patent Document 4: JP-A-2004-67547 [0006] Hitherto, as implant materials for implanting into the living body, hard tissue inductive implant materials such as artifi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61C8/00C12N5/07C12N5/071C12N5/077
CPCA61F2002/30011A61F2/28A61L27/56A61L27/04A61F2310/00568A61F2250/0023A61F2/34A61F2/30767A61F2/30965A61F2002/3092A61F2310/00155A61F2310/00976A61F2/30756A61C8/0018A61C8/0012A61F2/32A61L27/30A61F2002/4648A61B17/80A61F2002/30968A61F2310/00407A61F2002/30766A61F2002/30762A61F2310/00023A61F2310/00796
Inventor 久保木芳德关康夫盐田博之
Owner HI-LEX CORPORATION
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