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Preparation method of self-adhering super strong hydrogel

A hydrogel, self-adhesive technology, applied in medical science, bandages, etc., can solve the problems of lack of self-healing properties, reduced gel adhesion, consumption of phenolic hydroxyl groups, etc., to achieve excellent biocompatibility, improve Biocompatibility, the effect of improving adhesion

Active Publication Date: 2018-07-10
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This patent utilizes catechol and Fe in dopamine catechol 3+ Complexation cross-linking, but this cross-linking method has the following defects: 1. Add Fe 3+ There are toxic and side effects; 2. Part of the phenolic hydroxyl group is consumed, on the one hand, the adhesion of the gel is reduced, on the other hand, the gel segment lacks self-healing hydrogen bonds and ionic bonds, and lacks self-healing properties
Therefore, the above-mentioned cross-linking methods limit the application of this type of gel in tissue engineering fields such as skin dressings and artificial skin.

Method used

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  • Preparation method of self-adhering super strong hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The concrete steps of the preparation method of self-adhesive superhydrogel are:

[0037] a. Dissolve 1 g of hyaluronic acid HA in 0.01 mol / L PBS buffer solution, stir magnetically at room temperature for 4 hours to obtain HA solution with 1% hyaluronic acid mass fraction, and slowly adjust HA with 1-1.5 mol / L HCl solution Solution pH=4.0, add 0.47g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC, 0.28g N-hydroxysuccinimide NHS into the HA solution and stir until clear, Obtain solution A;

[0038] b. In ice water bath, N 2 Under protective conditions, add 0.65g of dopamine hydrochloride to solution A and react at 0°C for 12 hours, then dialyze in HCl solution with pH=4.0-5.0 and deionized water, filter and freeze-dry to obtain a grafting rate of 24%. Dopamine-modified hyaluronic acid HA-C;

[0039] c. Prepare 100 g of acrylamide aqueous solution with a mass fraction of 20%, add dopamine graft-modified hyaluronic acid HA-C, N,N-methylenebisacrylamide, ...

Embodiment 2

[0041] The concrete steps of the preparation method of self-adhesive superhydrogel are:

[0042] a. Dissolve 1 g of hyaluronic acid HA in 0.1 mol / L PBS buffer solution, stir magnetically at room temperature for 5 hours to obtain a HA solution with a mass fraction of 1.5% hyaluronic acid, and slowly adjust HA with 1-1.5 mol / L HCl solution Solution pH=4.5, add 0.5g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC, 0.25g N-hydroxysuccinimide NHS into the HA solution and stir until clear, Obtain solution A;

[0043] b. In ice water bath, N 2 Under protective conditions, add 0.7g of dopamine hydrochloride to solution A and react at 1°C for 14 hours, then dialyze in HCl solution with pH=4.0-5.0 and deionized water, filter and freeze-dry to obtain a grafting rate of 30%. Dopamine-modified hyaluronic acid HA-C;

[0044] c. Prepare 100 g of acrylamide aqueous solution with a mass fraction of 18%, add dopamine graft-modified hyaluronic acid HA-C, N,N-methylenebisacryla...

Embodiment 3

[0046] The concrete steps of the preparation method of self-adhesive superhydrogel are:

[0047] a. Dissolve 1 g of hyaluronic acid HA in 0.05 mol / L PBS buffer solution, stir magnetically at room temperature for 6 hours to obtain HA solution with 2% hyaluronic acid mass fraction, and slowly adjust HA with 1-1.5 mol / L HCl solution Solution pH=5.0, add 0.49g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC, 0.3g N-hydroxysuccinimide NHS into the HA solution and stir until clear, Obtain solution A;

[0048] b. In ice water bath, N 2 Under protective conditions, add 0.68g of dopamine hydrochloride to solution A and react at 2°C for 16 hours, then dialyze in HCl solution with pH = 4.0-5.0 and deionized water, filter and freeze-dry to obtain a grafting rate of 28%. Dopamine-modified hyaluronic acid HA-C;

[0049] c. Prepare 100 g of acrylamide aqueous solution with a mass fraction of 19%, add dopamine graft-modified hyaluronic acid HA-C, N,N-methylenebisacrylamide,...

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Abstract

The invention discloses a preparation method of a self-adhering super strong hydrogel, and is characterized in that the preparation method comprises the steps: adding dopamine grafted modified hyaluronic acid into an acrylamide aqueous solution, adding N,N-methylene bisacrylamide and ammonium persulfate, fully stirring evenly, and carrying out sealed vacuumization for 10-15 min; in an ice water bath and under a stirring condition, adding tetramethylethylenediamine, placing at the temperature of 0-4 DEG C, and crosslinking for 12-16 h, to obtain the self-adhering super strong polyacrylamide hydrogel. The prepared self-adhering super strong hydrogel has the following advantages: 1, the adhesion strength is large, is up to 12.3 kPa and is 3-4 times that of a pure polyacrylamide gel; and during use, an auxiliary adhesive or adhesive tape and the like does not need, and the self-adhering super strong hydrogel can adhere onto the surface of any material; and 2, the self-adhering super stronghydrogel has self-healing and self-repairing properties and can be self-healed in 20-30 min.

Description

technical field [0001] The invention relates to biomedical materials, in particular to a method for preparing self-adhesive superhydrogel. Background technique [0002] In terms of biomedical materials, hydrogel materials have excellent soft and wet properties and biocompatibility similarity. Based on this, this type of material has important application prospects in the fields of bionic smart devices, tissue engineering scaffolds, disease diagnosis and treatment, and wound dressing materials. In terms of tissue repair, most traditional polymer hydrogels lack tissue adhesion. At present, in the field of wearable bioelectronic devices and artificial skin, the preparation of strong adhesion and toughness hydrogel has important application value. [0003] Inspired by the adhesion protein rich in catechol structure in marine mussel silk, dopamine is often introduced into biocompatible polypeptide chains or polymer chains through chemical modification to prepare adhesive water....

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F220/56C08F222/38A61L26/00
CPCA61L26/0014A61L26/0023A61L26/008C08F251/00C08F220/56C08F222/385
Inventor 曹一平郑志强贝中武商伶俐张玮莹陈勇
Owner JIANGHAN UNIVERSITY
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