Biocomposite patch for female pelvic floor and manufacturing method thereof

A technology of female pelvic floor and composite patch, which is applied in the fields of medical science, prosthesis, coating, etc., can solve the problems of unstable long-term efficacy of natural degradability, etc., and achieves improved biocompatibility, improved stability, excellent Using the effect of the effect

Inactive Publication Date: 2011-12-07
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these materials have their own unique defects that are difficult to overcome, and they are all in the experimental stage.
Among the alternative materials, the heterogeneous acellular matrix material has the most ideal characteristics. It has a wide range of sources, good strength, an

Method used

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  • Biocomposite patch for female pelvic floor and manufacturing method thereof
  • Biocomposite patch for female pelvic floor and manufacturing method thereof
  • Biocomposite patch for female pelvic floor and manufacturing method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0032] 1. Preparation of porcine bladder acellular matrix

[0033] Take the fresh pig bladder specimens within half an hour after the death of closed breeding pigs (body weight about 200kg), and remove the mucous membrane layer and serosa layer mechanically under the ultra-clean bench.

[0034] 2. Decellularization treatment

[0035] The first treatment: Take a clean 1000ml beaker, weigh 12.11g of tris and 0.0122g of phenylmethylsulfonyl fluoride, add about 800ml of deionized water, stir well to dissolve, and adjust the pH value to 8.0. Put the solution into a clean 5000ml beaker, and soak the bladder matrix in the beaker. Place the beaker on a magnetic stirrer for 12 hours and overnight.

[0036] The second treatment: take a clean 1000ml beaker, weigh 12.11g of tris hydroxymethylaminomethane and 0.0122g of phenylmethylsulfonyl fluoride, add about 800ml of deionized water, stir well to dissolve, adjust the pH value to 8.0, Then put it into a clean 5000ml beaker, and soak th...

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PUM

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Abstract

The invention relates to a biological composite patch for female pelvic floor and a manufacturing method thereof, and according to the patch, a surface of a polypropylene mesh is coated with a bladder acellular matrix of an animal donor. A bladder obtained from an animal donor needs to be treated by decellularization and freeze-drying; after disinfection, the treated bladder is preserved by plastic packaging at a low temperature; then the obtained bladder acellular matrix is coated onto a surface of a polypropylene mesh. The invention effectively combines biomaterials with inorganic materials, and with the integration of the advantages of both materials, obviously excellent using effect is obtained. Thereinto, the external bladder matrix has the effect of insulating the polypropylene mesh from host tissue, and can significantly improve the biocompatibility. After the patch is implanted, fibrous tissue of a patient is induced to grow into the patch, and finally the restoration of the fibrous tissue of the patient itself is realized.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a patch for repairing female pelvic cavity tissue defects. Background technique [0002] Female pelvic floor dysfunction is a common disease and frequently-occurring disease in middle-aged and elderly women over 50 years old, which seriously affects the life and health of middle-aged and elderly women. The current treatment method is to use some mesh belts or sheets of medical polypropylene synthetic materials to reconstruct the pelvic floor function through surgery. Compared with biological materials, inorganic materials are prone to cause severe inflammatory reactions. Clinical results show that polypropylene mesh has the disadvantages of tissue erosion, poor biocompatibility, and is prone to discomfort caused by foreign body stimulation, tissue erosion, and dyspareunia. Fusion, coupled with aging and hardening and brittleness in the body, friction, displacement, erosion a...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/28A61L27/16
Inventor 梁志清刘禄斌徐惠成王延洲
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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