Potassium cantharidate and preparation method thereof

Abstract

The invention discloses potassium cantharidate of a structural formula below. The preparation method comprises: adding trichloromethane or isopropanol into pure cantharidin according to a weight ratio of (30-50):1, heating to dissolve the trichloromethane or isopropanol, and adding distilled water into potassium hydroxide according to a molar ratio of the potassium hydroxide to the cantharidin of 3:(2-3) to prepare solution at a weight concentration of 10 percent; adding the solution of potassium hydroxide into the trichloromethane or isopropanol solution containing cantharidin, heating the mixed solution to 60 to 75 DEG C, volatilizing trichloromethane or isopropanol till dryness, and filtering to obtain colorless transparent solution; and adding trichloromethane or isopropanol in a volume which is 2 to 5 times that the filtrate into filtrate, separating to obtain upper colorless transparent aqueous solution, placing the colorless transparent aqueous solution in an oven for concentration and drying to obtain white crystalline powder. The potassium cantharidate has high anticancer activity, the process is simple, easy to operate and very safe, and the finished product is stable in properties and high in purity.

Description

Potassium cantharidinate and preparation method thereof technical field The invention belongs to the technical field of chemistry, in particular to a kind of potassium cantharidinate, and also relates to a preparation method of the potassium cantharidinate. Background technique In the first and second centuries, my country began to use mylabris to treat tumors. Later, it was confirmed that the cantharidin and cantharidin derivatives secreted by the cantharidin were the main effective substances. Because cantharidin is insoluble in water, it is often used as an oral drug application, which limits the application range of cantharidin. Later, people developed sodium cantharidinate to increase water solubility and reduce toxicity. Using this excellent property, developed a Cantharidin Sodium Injection can be injected directly. So far, Cantharidin Sodium Injection has been successfully applied clinically and achieved remarkable results. However, when the toxicity of sodium ca...

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Problems solved by technology

However, when sodium cantharidinate reduces toxicity, its anticancer activity decreases greatly, which urgently requires the development of other new cantharidin derivatives with higher anticancer activity to solve this problem

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