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An anticancer medicinal composition, preparing method and use thereof

A composition and drug technology, applied in the field of medicine, to achieve the effect of reducing toxicity, wide application prospects, and definite curative effect

Inactive Publication Date: 2007-08-01
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, using the interaction of cantharidin or its derivatives or its analogs with one or more of Ganoderma lucidum, lentinan, and Poria cocos for the preparation of anticancer drugs has not been reported yet.

Method used

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  • An anticancer medicinal composition, preparing method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] The preparation of embodiment 1 Ganoderma lucidum extract

[0142] Take Ganoderma lucidum, crush it into coarse grains, add 3 times the amount of water to moisten overnight, decoct three times the next day, add 12 times the amount of water for the first 3 hours, add 10 times the amount of water for the second 2 hours, add 10 times the amount of water for the third 1 hour Double the amount, combine the decoction, filter, concentrate the filtrate to a relative density of 1.10-1.15, let it cool, add ethanol to make the alcohol content 80%, stir well, place it at 4°C for 24 hours, filter, and collect the filter cake. Add appropriate amount of water to dissolve, filter, add ethanol to make the alcohol content 85%, stir well, place at 4°C for 24 hours, filter, collect filter cake, add appropriate amount of acetone and ethanol to wash, filter with suction, add appropriate amount of water to precipitate It is dissolved, ultrafiltered, and the fraction with a molecular weight ...

Embodiment 2

[0153] Example 2 Preparation of Poria cocos extract

[0154] Take Poria cocos, crush it into fine powder, add 0.5mol / L sodium hydroxide solution to extract twice, stir, add 8 times the amount of solvent for the first 4 hours, add 6 times the amount of solvent for the second 3 hours, and stir at low temperature, Suction filtration, combined filtrates, neutralized with 10% acetic acid, refrigerated for 12 hours, and filtered. The precipitate was washed successively with water, acetone and ether, and dried to obtain the obtained product.

[0155] Identification of Poria cocos extract

[0156] (1) Take 1g of Poria cocos extract powder, add 10ml of acetone, heat to reflux for 10 minutes, filter, evaporate the filtrate to dryness, add 1ml of glacial acetic acid to dissolve the residue, add 1 drop of sulfuric acid, it becomes light red, and then turns brown.

[0157] (2) Take a small amount of Poria cocos extract powder, add 1 drop of potassium iodide test solution, and it will app...

Embodiment 3

[0166] The preparation of embodiment 3 BL, BX, BF composition powder injection

[0167] 1. Prescription:

[0168] Recipe 1: BL composition

[0169] Norcantharidin 10g

[0170] Ganoderma lucidum extract 57.2g (equivalent to 4kg of raw medicinal materials)

[0171] Sodium hydroxide 5g

[0172] Polysorbate 80 50g

[0173] Add sterile water for injection to 3000ml

[0174]

[0175] A total of 1000 sticks were prepared

[0176] Prescription 2: BX composition

[0177] Norcantharidin 10g

[0178] Lentinan 4g

[0179] Sodium hydroxide 5g

[0180] Polysorbate 80 50g

[0181] Add sterile water for injection to 3000ml

[0182]

[0183] A total of 1000 sticks were prepared

[0184] Recipe 3: BF composition

[0185] Norcantharidin 5g

[0186] Poria cocos extract 416g (equivalent to 5kg of the original medicinal material)

[0187] Sodium hydroxide 5g

[0188] Polysorbate 80 100g ...

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Abstract

The invention belongs to medical domain; it has disclosed a compound medicine that contains cantharidin orits derivates and at least one kind of medicine that can improve the immunity, the preparing method and application is also mentioned in the invention. The medicine that can improve immunity is chosen from one kind or various kinds of lentinan, ganoderma and hoelen. The medicine can be used to treat liver cancer, esophageal cancer, carcinoma of gastric cardia, lung cancer, malignant lymphoma and low blood corpuscle; it can also be used to treat hepatitis, cirrhosis or HB virus; it can be used as preoperative drug for cancer operation or be used in combination chemotherapy with the function of coordinated synergistic action. The product in the invention has good stability and the effects have been greatly improved than the single application of Norcantharidin, lentinan, ganoderma and hoelen. The medicine can be made into any medically acceptable dosage with any medically acceptable accessories so it has wide prospects.

Description

1. Technical field [0001] The invention relates to a composition containing cantharidin or its derivatives or analogs and at least one drug capable of enhancing immunity, its preparation method and application, and belongs to the technical field of medicine. 2. Background technology [0002] Cancer is a kind of disease that seriously threatens human life and health. According to statistics, about 1 million cancer patients are newly discovered in my country every year, while the world kills about 6 million people every year, and puts 10 million people on the verge of death. With the deteriorating environment of human beings, the occurrence of cancer The rate is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of human beings in the 21st century. At present, the treatment of cancer in modern medicine is mainly surgical treatment combined with radiotherapy and chemotherapy. Although surgery can remove the primary focus,...

Claims

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Application Information

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IPC IPC(8): A61K36/076A61P37/04A61P35/00A61P1/16A61P31/20A61K31/365A61K31/715
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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