The preparation method of sodium cantharidinate

A technology of sodium cantharidin and cantharidin is applied in the directions of drug combination, active ingredients of heterocyclic compounds, organic chemistry, etc., can solve the problems of high price and time-consuming operation, and achieves the effects of simple operation, reduced production cost and direct effect.

Inactive Publication Date: 2011-12-14
GUIZHOU JINQIAO PHARMA
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0424] The technical problem that the present invention needs to solve is to disclose a kind of new preparation method of sodium cantharidate, to overcome the defective that prior art exists, for example in the original preparation method of sodium cantharidate, sodium cantharidate is synthesized and activated carbon decolorization is refined and divided into two parts. Step-by-step, time-consuming operation, etc., also overcomes the problems of using a large amount of expensive acetone and isopropanol in the original reaction process

Method used

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  • The preparation method of sodium cantharidinate
  • The preparation method of sodium cantharidinate
  • The preparation method of sodium cantharidinate

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preparation example Construction

[0465] The present invention studies a new and efficient preparation method of sodium cantharidinate, and provides a new and efficient preparation method that can be used to prepare anti-cancer products such as medicines, etc. or the raw materials of anti-cancer products, especially medicines, which is convenient for the medical industry and related industries such as food, health products, beverages and other fields, including disease diagnosis, detection, treatment or scientific research.

[0466] The specific operation method of preparing Sodium Cantharidinate is set forth in detail below.

[0467] Add 20 grams of cantharidin (excellent product) into a 500 ml three-necked bottle, add 220 ml of 1N sodium hydroxide, heat to reflux for 1 hour, add 1 gram of activated carbon to decolorize and reflux for 30 minutes, heat filter, wash twice with water, and concentrate under reduced pressure to 20~ 30 ml, add 80 ml of ethanol, cool to room temperature, stir for 30 minutes, filter,...

Embodiment 1

[0485] Embodiment 1, the preparation of sodium cantharidate tablet

[0486] Prescription:

[0487]

[0488]

[0489] Process:

[0490] Get the prescription amount of sodium cantharidinate, pulverize through a 100-mesh sieve, then pulverize the prescription amount of starch and lactose through a 100-mesh sieve, and mix well. Add the total saponins of the pre-knowledge seed into the mixed starch and lactose, and mix well. Add an appropriate amount of 50% ethanol and mix well, granulate through a 16-mesh wire mesh, dry below 60°C, granulate, add an appropriate amount of magnesium stearate, mix evenly, analyze the content and then compress into tablets. Can be made into 1000 tablets each containing 0.5mg sodium cantharidinate.

Embodiment 2

[0491] Embodiment 2, the preparation of sodium cantharidinate capsule

[0492] Prescription:

[0493]

[0494] Process:

[0495] Get the prescribed amount of sodium cantharidate, pulverize through a 100-mesh sieve, add the prescribed amount of starch and micropowder silica gel, mix evenly, and directly pack into capsules to make 1000 capsules each containing 0.5 mg of sodium cantharidinate.

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Abstract

The invention relates to the technical fields of medicine, food and health products, and discloses a highly efficient preparation method of antitumor drug sodium cantharidinate. Add cantharidin essence into sodium hydroxide aqueous solution, heat to dissolve, add activated carbon to reflux for decolorization for 0.5-1 hour, heat filter, wash with water, concentrate under reduced pressure, add ethanol, cool to room temperature, precipitate solid and dry to obtain white powder. Wherein the equivalent ratio of cantharidin fines and sodium hydroxide is 1:2-3, and the weight ratio of cantharidin and ethanol is 1:3-10. The synthesis of sodium cantharidinate and the decolorization and refining of activated carbon are completed simultaneously, and the crystallization is carried out with ethanol-water system. The invention provides a synchronous method for synthesizing sodium cantharidate and decolorizing and refining activated carbon, the preparation process is simpler, the reaction cycle is shortened, the application of a large amount of acetone and isopropanol is omitted in the reaction process, the production cost is reduced, and The pollution to the environment is small, the quality control is simpler, the production efficiency is improved, and the industrial production is convenient.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food, health care products and beverages, in particular to a preparation method of a compound, more specifically to a preparation method of an antitumor drug derived from the extract of the Chinese medicine Mylabris, and more specifically Said to relate to a kind of high-efficiency preparation method of compound sodium cantharidinate. Background technique [0002] (1) Research overview of cantharidin and cantharidin [0003] 1 Overview [0004] Explanation of Canthari in Chinese-English Dictionary (Source: Baidu Dictionary): a Chinese blister beetle; cantharides. Mylabris has the functions of breaking knots and attacking poison, removing blood accumulation, and diuresis. Show according to modern pharmacological research: mylabris also has the effect of antitumor, antiviral. [0005] Cantharidin is a compound with anti-tumor activity extracted from the traditional Chinese medicine M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08A61K31/34A61P35/00
Inventor 张芝庭张涛涛
Owner GUIZHOU JINQIAO PHARMA
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