Cantharidin vesicles and preparation thereof and preparation methods of cantharidin vesicles and preparation thereof

A technology of cantharidin and vesicles, which is applied in the field of cantharidin vesicles and its preparation, can solve the problems of unsafety, large toxic and side effects, and limited application, and achieve the effects of improving safety, increasing drug efficacy, and reducing toxic and side effects

Inactive Publication Date: 2012-07-18
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As an effective part or component of traditional Chinese medicine, cantharidin has remarkable clinical curative effect, but its toxic and side effects are very large and unsafe, which greatly limits its clinical application. The transdermal external preparation has unique advantages for this drug, and the application of new vesicles The drug delivery system can improve the transdermal absorption of drugs, solve the toxic and side effects of drugs during oral and injection administration, and increase the compliance of patients with clinical drug administration. It will have broad application prospects and will produce good social benefits and considerable economic benefits. benefit

Method used

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  • Cantharidin vesicles and preparation thereof and preparation methods of cantharidin vesicles and preparation thereof
  • Cantharidin vesicles and preparation thereof and preparation methods of cantharidin vesicles and preparation thereof
  • Cantharidin vesicles and preparation thereof and preparation methods of cantharidin vesicles and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Get 0.3g of cantharidin, 602.8g of span, and 0.3g of cholesterol, dissolve them in absolute ethanol, remove the solvent by rotary evaporation (60°C), add pH to the ammonium sulfate buffer solution of 6.8, stir at 20°C until the ethanol evaporates, and ultrasonically Treat for 30 minutes, leave it at room temperature to cool down, and obtain the vesicle suspension of cantharidin.

[0103] Take 0.1g of HPMC (K-6000), 1g of glycerin, 0.5g of potassium sorbate, add 100ml of purified water to prepare a blank gel matrix, and mix the vesicle suspension and the blank gel matrix to obtain the vesicle gel matrix. glue.

Embodiment 2

[0105] Get 3g of cantharidin, 8060g of spar, and 50g of stearamide, dissolve in ether, remove the solvent by rotary evaporation (60°C), dry in vacuo overnight, add pH to ammonium sulfate buffer solution of 6.5, hydration temperature 60°C, hydration time After 30 minutes, it was processed with a high-pressure homogenizer to obtain a cantharidin vesicle suspension.

[0106] Take carbomer 94112g, propylene glycol 120g, triethylamine 6g, menthol 6g, ethylparaben 30g, add purified water 3000ml to prepare a blank gel matrix, mix the blank gel matrix and vesicle suspension, The vesicle gel is obtained.

Embodiment 3

[0108] Take 10g of cantharidin, 40-300g of Span, 100g of dicetyl phosphate, and 140g of octadecylamine dissolved in methanol, remove the solvent by rotary evaporation (55°C), add purified water for hydration, the hydration temperature is 65°C, the hydration time is 45min, and the ultrasonic treatment is 30 Minutes, the vesicle suspension of cantharidin is obtained.

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Abstract

The invention discloses cantharidin vesicles and a preparation method thereof, and a preparation containing the cantharidin vesicles and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The cantharidin vesicles are prepared from cantharidin, a nonionic surfactant and an additive and are preferably prepared into an external gel preparation. A cantharidin percutaneous delivery external preparation has unique advantage over the medicament and is applied to a novel vesicle administration system, so that the percutaneous absorption of the medicament is increased, the clinical curative effect is enhanced, and the cantharidin percutaneous delivery external preparation can be used for treating cancer, specifically liver cancer, and has a liver targeting effect.

Description

technical field [0001] The invention relates to cantharidin vesicles and a preparation method thereof, a preparation containing cantharidin vesicles and a preparation method thereof, and belongs to the field of pharmaceutical preparations. Background technique [0002] According to modern pharmacological research, human beings have used mylabris to treat diseases for more than 2,000 years. Mylabris is the dry body of the Myracariaceae insect southern large mylabris or the yellow and black small mylabris. Li Shizhen, a great medical scientist in the Ming Dynasty, said in the masterpiece "Compendium of Materia Medica" that mylabris is pungent, cold, and highly poisonous. Injury human muscle, cure scabies, abortion, cure scrofula, unblock waterways, cure gonorrhea, treat sores and fistulas, cure hernia, detoxify furunculosis, cure rabies, etc. In recent years, the research on cantharidin has mainly focused on the exploration of the anti-cancer mechanism of its active ingredien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/34A61P17/14A61P35/00
Inventor 吴珍珍张卫华
Owner BEIJING INCREASEPHARM CORP LTD
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