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Method for extracting cantharidin from cantharides

A technology of cantharidin and cantharidin, applied in the direction of organic chemistry and the like, can solve the problems of large environmental pollution, low yield, high energy consumption, etc., and achieve the effects of reducing energy consumption, high extraction yield and production safety.

Inactive Publication Date: 2012-02-01
JIANGSU SIHUAN BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional extraction methods have various unfavorable factors in large-scale production, not only high cost, high energy consumption, large environmental pollution, but also low yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Get 27 kilograms of dried cantharidins, crush them, and put them into a feeding port of the continuous countercurrent ultrasonic extraction device. About 3 kg / hour, about 9 hours of treatment, a total of 27 kg, adjust the main screw motor speed to maintain the predetermined material residence time, that is, the average extraction time is 3 hours; from the lower end of the leaching chamber (the lower end of the leaching chamber refers to It is the area near the outlet valve of the leaching chamber of the continuous countercurrent ultrasonic extraction device) After running for 1 hour, adjust the outlet valve (the ratio of material to liquid is 1:5), discharge the liquid evenly, control the flow rate of solvent addition, and keep the liquid level in the leaching chamber balanced; After the final material is added to the hopper, it takes about 9 hours to be discharged from the slag outlet, and about 200 kg of leachate is collected.

[0020] Add an appropriate amount of pur...

Embodiment 2

[0022] Take 54 kg of dried cantharidins, crush them, control the feeding rate of insect powder to 1 kg / 10 minutes, and process about 6 kg / hour, process for about 9 hours, and process 54 kg in total. Adjust the speed of the main screw motor to maintain the predetermined material retention Time, that is, the average leaching time is 3 hours; after running for 1 hour from the lower end of the leaching chamber, adjust the liquid outlet valve (the ratio of material to liquid is 1:5), discharge the liquid evenly, control the flow rate of solvent addition, and keep the liquid level in the leaching chamber balanced ; After the final material is added to the hopper, it takes about 9 hours to discharge from the slag outlet, and about 400 kg of leachate is collected.

[0023] Add an appropriate amount of purified water to the leaching solution to remove lipid impurities, concentrate under reduced pressure and evaporate part of the solvent, and the concentrated solution is cooled and cryst...

Embodiment 3

[0025] Take 27 kg of dried cantharidins, crush them, control the feeding rate of insect powder to 0.5 kg / 10 minutes, process about 3 kg / hour, process for about 9 hours, and process 27 kg in total. Adjust the speed of the main screw motor to maintain the predetermined material retention Time, that is, the average leaching time is 3 hours; after running for 1 hour from the lower end of the leaching chamber, adjust the liquid outlet valve (the ratio of solid to liquid is 1:10), discharge the liquid evenly, control the flow rate of solvent addition, and keep the liquid level in the leaching chamber balanced ; After the final material is added to the hopper, it takes about 9 hours to discharge from the slag outlet, and about 400 kg of leachate is collected.

[0026] Add an appropriate amount of purified water to the leaching solution to remove lipid impurities, concentrate under reduced pressure and evaporate part of the solvent, and the concentrated solution is cooled and crystall...

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Abstract

The invention relates to a method for extracting cantharidin from cantharides. The method is characterized by comprising the following steps of: performing continuous countercurrent ultrasonic extraction on powder of cantharides by using acetone, removing impurities from an extracting solution, concentrating under reduced pressure, evaporating to remove partial solvent, and cooling and crystallizing a concentrated solution to obtain a crude product of cantharidin; heating to dissolve the crude product by using chloroform, filtering to remove insoluble substances, and cooling and crystallizing filtrate to obtain the cantharidin. The continuous countercurrent ultrasonic extraction is adopted, the impurities are removed from the extracting solution by an elutriation method, and recrystallization is carried out by using the chloroform, so that the cantharidin with the content of over 98 percent is obtained, steps of degreasing by using an organic solvent and the like are eliminated, the operation is simple, the production is safe, the extraction yield is high, and the method is suitable for mass production.

Description

technical field [0001] The invention relates to a method for extracting cantharidin from cantharidin. Background technique [0002] Methyleatharidinimide is a derivative of cantharidin, which has a great effect on both anti-cancer and whitening. It has a direct killing and inhibiting effect on cancer cells; it stimulates the bone marrow hematopoietic system and increases blood white blood cells. . [0003] More than 2,000 years ago, Chinese medicine in my country began to use mylabris to treat tumors. The medicine is pungent and cold in nature, poisonous, can attack toxins and erode sores, break blood and dissipate stagnation, and is a traditional Chinese medicine with obvious effects. However, the side effects are very serious. After taking it, the mucous membranes of the oral cavity and pharynx are congested, nausea and vomiting, loss of appetite, diarrhea, dysuria, frequent urination, hematuria, etc. And can not control the dosage of medicine, be difficult to apply cli...

Claims

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Application Information

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IPC IPC(8): C07D493/18
Inventor 孙国建江永红徐益明龚海燕沈振宇潘丽娟丁月萍缪岳平
Owner JIANGSU SIHUAN BIOENG
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