The invention discloses a traditional Chinese medicine composition for treating duodenal ulcer. According to the formula, water spinach roots, serrate glory-bower, roots of coix lacryma-jobi, leaves of coix lacryma-jobi, Xiatian leaven made from extract of beef, pinellia and other herbal medicine, persimmon frost, persimmon flowers, fructus evodiae, fructus amomi, hericium erinaceus, garcinia mangostana, Indian kalimeris herb, capsella bursa-pastoris and snow lotus herb serve as main medicines for tranquilizing the liver, regulating qi, strengthening the spleen, harmonizing the stomach and tonifying the spleen, the lung and the kidney. Roots of woolly lespedeza, flavedo, sanchi flowers, cherry leaves, phyllan lhus mat shilllirae, myristica fragrans, limonium bicolor, milkvetch roots, elsholtzia patrini garcke, clove tree bark, elecampane, Chinese wax, bauhinia roots, phaseolus calcaratus, water chestnut, apples, grapes, bananas and royal jelly serve as auxiliary medicines for invigorating the spleen and stomach, replenishing qi, tonifying the spleen, restoring deficiency, stopping bleeding and vomiting, relieving spasm and stopping pains. The traditional Chinese medicine composition is a traditional Chinese medicine preparation and can achieve the purposes of tranquilizing the liver, stopping pains, regulating qi, strengthening the spleen, tonifying the spleen and the kidney, stopping bleeding and vomiting, relieving spasm, stopping pains, improving the local blood circulation and metabolism, enhancing the gut immunity function and promoting anabrosis healing.