Novel radix astragali and poria cocos pill composition and production process thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a novel astragalus membranaceus and poria cocos pill composition and a production process thereof. The raw materials comprise the following components: astragalus membranaceus, codonopsis pilosula, poria cocos, radix angelicae, platycodon grandiflorum, liquorice, red dates, coix seeds, grape seeds, black sesame and spina date seeds. The traditional Chinese medicine composition comprises the following raw material components in parts by mass: 10-20 parts of astragalus membranaceus, 8-15 parts of codonopsis pilosula, 10-18 parts of poria cocos, 5-12 parts of radix angelicae, 6-14 parts of platycodon grandiflorum, 3-8 parts of liquorice, 8-16 parts of red dates, 10-20 parts of coix seeds, 5-10 parts of grape seeds, 8-15 parts of black sesame and 6-12 parts of spina date seeds. The invention has the following beneficial effects: shape optimization: 3-5mm pills are prepared, the pill is convenient to take, the dosage is easy to control, and compared with decoction and powder, the pill is more convenient to store and carry; the production process is simple, parameters of each step are clear, large-scale production can be realized by adopting conventional traditional Chinese medicine processing equipment, and the production cost is relatively low; and the quality is stable: by strictly controlling raw material moisture, crushing granularity, mixing uniformity and finished product drying parameters, the finished product is stable in quality and long in validity period.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, specifically to a novel Astragalus and Poria Cocos Pill composition and its production process. Background Technology

[0002] Traditional Chinese medicine (TCM) compositions are widely used in health preservation and body conditioning due to their advantages such as flexible compatibility, comprehensive efficacy, and few side effects. Astragalus and Poria cocos are traditional medicinal and edible ingredients. Astragalus has the effects of tonifying qi and raising yang, consolidating the exterior and stopping sweating, while Poria cocos has the effects of promoting diuresis and removing dampness, strengthening the spleen and calming the mind. The two are often used together in various conditioning compositions.

[0003] In the existing technology, compositions using Astragalus membranaceus and Poria cocos as raw materials are mostly in the form of decoctions, powders or ordinary pills. Some compositions have a single raw material composition, and the efficacy is not comprehensive enough. Moreover, the production process has problems such as complex procedures, poor mixing uniformity, and poor stability of finished products, which makes it difficult to meet consumers' needs for product efficacy, ease of use and storage stability.

[0004] Therefore, it is of great significance to develop a new Astragalus and Poria Cocos Pill combination that is scientifically formulated, has comprehensive efficacy, and has a simple and efficient production process. Summary of the Invention

[0005] To address the problems mentioned in the background art, the present invention aims to provide a novel Astragalus and Poria Cocos Pill composition and its production process.

[0006] To solve the above-mentioned technical problems, the technical solution provided by the present invention is as follows:

[0007] A novel Astragalus and Poria Cocos Pill composition is characterized by the following raw materials: Astragalus membranaceus, Codonopsis pilosula, Poria cocos, Angelica dahurica, Platycodon grandiflorus, Glycyrrhiza uralensis, Jujube, Coix lacryma-jobi, Grape seed, Black sesame, and Ziziphus jujuba seed.

[0008] Preferably, the mass fractions of each raw material component are as follows: Astragalus membranaceus 10-20 parts, Codonopsis pilosula 8-15 parts, Poria cocos 10-18 parts, Angelica dahurica 5-12 parts, Platycodon grandiflorus 6-14 parts, Glycyrrhiza uralensis 3-8 parts, Jujube 8-16 parts, Coix lacryma-jobi 10-20 parts, Grape seed 5-10 parts, Black sesame 8-15 parts, and Ziziphus jujuba var. spinosa 6-12 parts.

[0009] The production process of the novel Astragalus and Poria cocos composition is characterized by the following steps:

[0010] S1. Ingredients: Select raw materials that meet pharmaceutical or food grade standards according to the set mass proportions, remove impurities, clean them, and dry them until the moisture content is ≤8%;

[0011] S2. Crushing: Put the dried raw materials into the crushing equipment separately and crush them into 100-120 mesh fine powder. After sieving, they are ready for use.

[0012] S3. Mixing: Add the fine powders of each raw material to the mixing equipment and stir for 15-30 minutes to ensure uniform mixing. The coefficient of variation of the mixing uniformity should be ≤5%.

[0013] S4. Pelletizing: Add an appropriate amount of purified water as a binder to the well-mixed powder, stir to form a pill of suitable softness and hardness, and process it into pills with a diameter of 3-5mm using a pelletizing machine.

[0014] S5. Drying: Place the prepared pills in a drying device and dry them at 50-60℃ until the moisture content is ≤5%. After cooling to room temperature, the finished product is obtained.

[0015] Preferably, the drying method in step 1 is hot air drying or vacuum drying, and the drying time is 2-4 hours.

[0016] Preferably, the crushing equipment in step 2 is a universal crusher, and the sieve is a stainless steel screen.

[0017] Preferably, the mixing equipment in step 3 is a three-dimensional motion mixer with a stirring speed of 30-50 r / min.

[0018] The beneficial effects of this invention are:

[0019] Scientific formulation: It selects 11 kinds of medicinal and edible raw materials, and the effects of each component are complementary and synergistic. It takes into account the functions of replenishing qi and strengthening the spleen, removing dampness and calming the mind, as well as nutritional supplementation, and is suitable for a wide range of people.

[0020] Formation optimization: Made into 3-5mm pills, which are convenient to take and easy to control the dosage. Compared with decoctions and powders, they are more convenient to store and carry.

[0021] Highly efficient process: The production process is simple, the parameters for each step are clear, and large-scale production can be achieved using conventional Chinese medicine processing equipment, resulting in low production costs;

[0022] Stable quality: By strictly controlling the moisture content of raw materials, particle size, mixing uniformity, and drying parameters of finished products, we ensure stable quality and long shelf life of finished products.

[0023] Obviously, based on the above description of the present invention, and according to common technical knowledge and conventional methods in the field, various other modifications, substitutions or alterations can be made without departing from the basic technical concept of the present invention.

[0024] The following detailed embodiments further illustrate the above-described content of the present invention. However, this should not be construed as limiting the scope of the present invention to the following examples. All technologies implemented based on the above-described content of the present invention fall within the scope of the present invention. Detailed Implementation

[0025] The present invention is illustrated below with specific embodiments, which are not intended to limit the scope of the invention.

[0026] Raw materials and formulation principles of the composition:

[0027] The composition of this invention is made from 11 kinds of medicinal and edible raw materials, and the efficacy of each component is as follows:

[0028] Astragalus: It tonifies Qi and raises Yang, strengthens the exterior and stops sweating, and promotes diuresis and reduces swelling. It is the core Qi-tonifying ingredient in the composition.

[0029] Codonopsis pilosula: replenishes qi and strengthens the spleen and lungs, and assists Astragalus membranaceus in enhancing its qi-replenishing effects;

[0030] Poria cocos: It promotes diuresis and eliminates dampness, strengthens the spleen and calms the mind. When combined with Astragalus membranaceus and Codonopsis pilosula, its effect of strengthening the spleen and replenishing qi is even better.

[0031] Angelica dahurica: relieves exterior symptoms, dispels cold, eliminates wind and relieves pain, and also helps to regulate discomfort on the body surface;

[0032] Platycodon grandiflorus: promotes lung function, soothes the throat, eliminates phlegm, and clears lung qi to aid spleen and stomach digestion;

[0033] Licorice: It invigorates qi and nourishes the middle jiao, clears heat and detoxifies, harmonizes various medicines, and alleviates the conflicting properties of different raw materials;

[0034] Red dates: They replenish qi and blood, calm the mind, and provide nutrition while enhancing the spleen-strengthening and blood-nourishing effects.

[0035] Job's tears: promotes diuresis and eliminates dampness, strengthens the spleen and stops diarrhea, and assists Poria cocos in enhancing its dampness-removing and spleen-strengthening effects;

[0036] Grape seeds: rich in antioxidants and also provide nutritional supplementation;

[0037] Black sesame seeds: nourish the liver and kidneys, replenish essence and blood, and enrich the nutritional components of the formula;

[0038] Sour jujube seed: Nourishes the heart and liver, calms the mind and soothes the nerves, and improves sleep-related discomfort.

[0039] The components work synergistically to achieve a comprehensive effect of "tonifying qi and strengthening the spleen, removing dampness and calming the mind, and providing nutrition", making it suitable for daily health maintenance.

[0040] Detailed description of the production process:

[0041] Ingredients: All raw materials are strictly screened to remove unqualified parts such as mold, insects, and impurities. Surface dust and contaminants are washed with purified water and then dried to ensure that the moisture content of the raw materials is controlled at ≤8% to avoid problems such as clumping and mold growth during subsequent processing.

[0042] Grinding: Each dry raw material is individually ground using a universal grinder. After grinding, the powder is sieved through a 100-120 mesh stainless steel screen to ensure uniform particle size and improve the uniformity of subsequent mixing and pelletizing effect.

[0043] Mixing: Put the fine powder of each raw material into a three-dimensional motion mixer, set the speed to 30-50 r / min, and mix for 15-30 minutes. The powder is fully mixed by the multi-directional movement of the equipment. The coefficient of variation of the mixing uniformity is controlled at ≤5% to ensure that the content of each component in each pill is consistent.

[0044] Pelletizing: Slowly add purified water to the mixed powder while stirring to form a soft and firm ball that can be formed into a ball by hand and easily dispersed by touch. Put the ball into a pelletizing machine, adjust the equipment parameters, and process it into uniform pills with a diameter of 3-5mm. This size is convenient for taking and swallowing.

[0045] Drying: Place the wet pills after pelleting into a hot air drying oven or vacuum drying equipment and dry them at 50-60℃ for 2-4 hours until the moisture content of the pills is ≤5%. The drying temperature should be gentle to avoid high temperature damaging the effective components of the raw materials. After drying, allow them to cool naturally to room temperature to obtain the finished product.

[0046] Example 1,

[0047] Ingredient ratio (parts by weight): Astragalus membranaceus 15 parts, Codonopsis pilosula 10 parts, Poria cocos 12 parts, Angelica dahurica 8 parts, Platycodon grandiflorus 10 parts, Glycyrrhiza uralensis 5 parts, Jujube 12 parts, Coix lacryma-jobi 15 parts, Grape seed 7 parts, Black sesame 10 parts, Ziziphus jujuba var. spinosa 8 parts;

[0048] Production process:

[0049] Ingredients: Select the above-mentioned parts by weight of each raw material, remove impurities, wash with purified water, and dry with hot air for 3 hours, controlling the moisture content to 6%;

[0050] Grinding: Each raw material is ground separately using a universal grinder and then passed through a 110-mesh stainless steel sieve;

[0051] Mixing: All fine powders were added to a three-dimensional motion mixer and mixed at 40 rpm for 20 minutes, with a mixing uniformity variation coefficient of 3%.

[0052] Pill making: Add an appropriate amount of purified water to form a pill mass, and process it into pills with a diameter of 4mm using a pill-making machine;

[0053] Drying: Dry with hot air at 55℃ for 3 hours, the moisture content of the pills is 4%, and the finished product is obtained after cooling.

[0054] Example 2,

[0055] Ingredient ratio (parts by weight): Astragalus membranaceus 12 parts, Codonopsis pilosula 8 parts, Poria cocos 10 parts, Angelica dahurica 6 parts, Platycodon grandiflorus 8 parts, Glycyrrhiza uralensis 3 parts, Jujube 10 parts, Coix lacryma-jobi 12 parts, Grape seed 5 parts, Black sesame 8 parts, Ziziphus jujuba var. spinosa 6 parts;

[0056] Production process:

[0057] Ingredients: After washing, vacuum dry for 2.5 hours, moisture content 5%;

[0058] Grind: Pass through a 100-mesh sieve;

[0059] Mixing: Mix at 35 rpm for 25 minutes, with a coefficient of variation of 4% for mixing uniformity;

[0060] Pill making: Prepare pills with a diameter of 3.5 mm;

[0061] Drying: Vacuum dry at 50℃ for 3.5 hours, moisture content 3.5%, then cool to obtain the finished product.

[0062] Example 3,

[0063] Ingredient ratio (parts by weight): Astragalus membranaceus 18 parts, Codonopsis pilosula 14 parts, Poria cocos 16 parts, Angelica dahurica 10 parts, Platycodon grandiflorus 12 parts, Glycyrrhiza uralensis 7 parts, Jujube 15 parts, Coix lacryma-jobi 18 parts, Grape seed 9 parts, Black sesame 14 parts, Ziziphus jujuba var. spinosa 10 parts;

[0064] Production process:

[0065] Ingredients: Hot air dried for 4 hours, moisture content 7%;

[0066] Grind: Pass through a 120-mesh sieve;

[0067] Mixing: Mix at 45 rpm for 18 minutes; the coefficient of variation for mixing uniformity is 2.5%.

[0068] Pill making: Prepare pills with a diameter of 4.5mm;

[0069] Drying: Dry with hot air at 60℃ for 2.5 hours until the moisture content is 4.5%, then cool to obtain the finished product.

[0070] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0071] The above description is merely a preferred embodiment of the present invention and does not limit the patent scope of the present invention. Any equivalent structural transformations made using the contents of the present invention under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

[0072] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A novel composition of Astragalus and Poria cocos Dan, characterized in that, The raw materials are composed of Huangqi, Dangshen, Fuling, Baizhi, Jiegeng, Gancao, Hongzao, Yiyiren, Putaose, Heizhima, Suanzhiren.

2. The novel composition of Astragalus and Poria cocos Dan according to claim 1, characterized in that, The mass fraction of each raw material component is: Huangqi 10-20 parts, Dangshen 8-15 parts, Fuling 10-18 parts, Baizhi 5-12 parts, Jiegeng 6-14 parts, Gancao 3-8 parts, Hongzao 8-16 parts, Yiyiren 10-20 parts, Putaose 5-10 parts, Heizhima 8-15 parts, and Suanzhiren 6-12 parts.

3. A process for the production of the novel composition of Astragalus and Poria cocos as claimed in claim 1 or 2, characterized in that, The method comprises the following steps: S1. Dosing: Select each raw material according to the set mass fraction, remove impurities, clean, and dry to a moisture content of ≤8%; S2. Grinding: Put each dried raw material into a grinding device, grind to 100-120 mesh fine powder, and sieve for standby; S3. Mixing: Add each raw material powder into a mixing device, stir and mix for 15-30 minutes to ensure uniform mixing, and the uniform mixing variation coefficient is ≤5%; S4. Pill making: Add an appropriate amount of purified water as a binder to the mixed powder, stir to form a soft and hard medicine mass, and use a pill making machine to process into Dan pills with a diameter of 3-5 mm; S5. Drying: Place the prepared Dan pills in a drying device, dry at 50-60°C until the moisture content is ≤5%, and cool to room temperature to obtain the finished product.

4. The production process according to claim 3, characterized in that, The drying method in step 1 is hot air drying or vacuum drying, and the drying time is 2-4 hours.

5. The production process according to claim 3, characterized in that, The grinding device in step 2 is a universal grinder, and the sieving uses a stainless steel screen.

6. The production process according to claim 3, characterized in that, The mixing device in step 3 is a three-dimensional motion mixer, and the stirring speed is 30-50 r / min.