A traditional Chinese medicine composition for regulating sub-health and a preparation method thereof

Abstract

This invention discloses a traditional Chinese medicine composition for regulating sub-health conditions and its preparation method, belonging to the technical field of traditional Chinese medicine compositions. This composition is made from a specific weight ratio of raw materials including Asparagus cochinchinensis, Lilium brownii, Poria cocos, Triticum aestivum, Polygonatum sibiricum, Morus alba, Black sesame, Walnut, Ginseng, Lycium barbarum, Angelica dahurica, Rose, Jujube, Honey, Citrus medica, Tangerine peel, Lotus seed, Prunus persica, Amomum villosum, Chrysanthemum morifolium, Hawthorn, Dioscorea opposita, Pueraria lobata, and Coix lacryma-jobi, with optional addition of natural Vitamin C. Based on the principles of traditional Chinese medicine (TCM) theory of monarch, minister, assistant, and guide herbs, this invention has the effects of invigorating Qi and nourishing Yin, strengthening the spleen and removing dampness, soothing the liver and regulating Qi, nourishing blood and calming the mind, and moisturizing the skin and beautifying the complexion. It effectively improves sub-health symptoms such as insomnia, fatigue, loss of appetite, and excessive dampness. This invention is suitable for people with difficulty swallowing and those requiring rapid onset of action. All dosage forms maintain the characteristics of mild medicinal properties, safety without side effects, simple preparation, and convenient administration, making it suitable for long-term daily conditioning and showing good application prospects.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine composition technology, and specifically relates to a traditional Chinese medicine composition for regulating sub-health and its preparation method. Background Technology

[0003] Sub-health is not a single disease, but a complex syndrome involving multiple systems and organs, a mixture of deficiency and excess, cold and heat, and imbalances in qi, blood, and body fluids. Its core pathogenesis is mainly manifested in six categories: deficiency of both qi and yin, weakness of the spleen and stomach, stagnation of liver qi, restlessness, internal accumulation of dampness and turbidity, and stagnation of qi and blood. The clinical symptoms are complex and diverse and intertwined, mainly including: persistent fatigue and weakness, lethargy, memory loss, poor concentration, insomnia and dreaminess, difficulty falling asleep, easy awakening and early awakening, anxiety and irritability, low mood, chest tightness and rib distension, loss of appetite, indigestion, abdominal distension and loose stools, sticky stools, bitter taste in the mouth and bad breath, heaviness in the head and body, soreness in the limbs, sallow complexion, dull skin, increased age spots, dry and rough skin, decreased immunity, susceptibility to colds, endocrine disorders, irregular menstruation, hair loss and graying, soreness in the lower back and knees, dizziness and tinnitus, and decreased sexual function. The above symptoms are persistent and recurring, sometimes mild and sometimes severe. Western medical examinations often show no clear organic lesions, but they seriously affect work efficiency, quality of life and physical and mental health. If left untreated for a long time, they can gradually develop into chronic diseases such as hypertension, diabetes, fatty liver, insomnia, anxiety, chronic fatigue syndrome, and tumors.

[0004] Currently, products and solutions for sub-health conditioning on the market suffer from prominent defects such as simple mechanisms, crude formulations, outdated processes, poor safety, low compliance, and limited effectiveness. These shortcomings make it difficult to meet the needs of sub-healthy individuals for long-term, gentle, comprehensive, and safe conditioning. Specific problems are as follows: The treatment approach is one-sided and lacks the holistic view and syndrome differentiation and treatment thinking of traditional Chinese medicine. Modern medicine often adopts a symptomatic intervention approach. For insomnia, using sedative-hypnotic drugs alone can easily lead to dependence, drug tolerance, and memory impairment. For fatigue, blindly supplementing with vitamins, protein powder, and energy drinks may provide short-term relief but cannot address underlying deficiencies. For excessive dampness, simply using diuretics and dampness-removing ingredients can easily lead to "dampness removal depleting qi and damaging yin fluids," resulting in increased fatigue and dry mouth. Existing traditional Chinese medicine health products often consist of single herbs or a simple combination of a few herbs, lacking proper formulation and coordination. They may also excessively tonify qi, causing dryness and heat; simply nourish yin, causing coldness and spleen damage; excessively remove dampness, depleting qi and damaging yin; or simply invigorate blood, causing blood depletion and movement. These approaches are often inefficient and fail to achieve the balance required for tonifying qi without causing dryness, nourishing yin without causing coldness, removing dampness without damaging yin, regulating qi without depleting qi, and invigorating blood without causing blood loss. Consequently, they cannot fundamentally correct multiple organ dysfunctions.

[0005] The raw materials are of mixed origin, the formulation lacks scientific basis, and the effects overlap or antagonize. The formulations are simply a hodgepodge of ingredients like red beans, Job's tears, goji berries, red dates, and astragalus, lacking a clear logical combination, resulting in overlapping or antagonistic effects. For example, many dehumidification products only contain red beans and Job's tears, neglecting to strengthen the spleen and replenish qi, nourish yin and generate fluids, making it difficult to eliminate dampness repeatedly; calming products rely on jujube seeds and lily bulbs, neglecting to soothe the liver and regulate qi, strengthen the spleen and nourish the heart, making it difficult to alleviate emotional problems; beauty products focus on collagen and donkey-hide gelatin, neglecting to nourish the liver and kidneys, regulate qi and blood, and clear internal heat, resulting in short-lived skin improvements. In addition, many products add sucrose, maltose, flavorings, colorings, and preservatives, increasing the burden on the spleen and stomach, weakening the conditioning effect, and long-term use can easily induce obesity, abnormal blood sugar, and intestinal flora imbalance.

[0006] The preparation process is crude and outdated, resulting in severe loss of active ingredients and extremely low bioavailability. Traditional health powders, pills, and ointments often employ high-temperature frying, long-term boiling, and high-temperature drying processes, with temperatures generally exceeding 80℃. This results in the significant destruction and loss of heat-sensitive active substances in medicinal materials: in flower-based medicinal materials (rose, chrysanthemum), the volatile oils (linalool, geraniol, chrysanthemum lactone) that soothe the liver, relieve depression, and have antioxidant properties are almost completely decomposed; in root and rhizome-based medicinal materials (ginseng, polygonatum, kudzu root), the saponins, polysaccharides, and flavonoids that replenish qi, nourish yin, and regulate immunity are degraded; in seed-based medicinal materials (black sesame, walnut), unsaturated fatty acids and vitamin E are oxidized and deteriorated; and in fruit-based medicinal materials (mulberry, hawthorn, goji berry), vitamins, anthocyanins, and organic acids are lost in large quantities. Meanwhile, most processes do not differentiate treatment based on the characteristics of medicinal materials: root, rhizome, seed, flower and fruit medicinal materials are mixed in the same pulverizing process, resulting in uneven particle size, low cell wall breakage rate and poor dissolution of effective ingredients; without fine processing such as low temperature extraction, low temperature drying and gradient pulverization, the finished product has low content of effective ingredients, poor absorption and slow effect, and the dosage is large but the conditioning effect is weak.

[0007] Significant safety concerns, high risks with long-term use, and poor adherence. Traditional Chinese medicine decoctions are cumbersome, time-consuming, bitter, and have an unpleasant smell, making them difficult for modern people to adhere to long-term. Ordinary pills and tablets disintegrate slowly and are poorly absorbed; powders clump together when mixed with water and have a rough texture; and ointments are high in sugar, sticky, and difficult to swallow. Most people in a sub-healthy state are young and middle-aged office workers, women, and the elderly with weak constitutions. They have extremely high requirements for product safety, gentleness, portability, taste, non-addictiveness, and long-term suitability. Existing products often fail to meet these requirements, leading to interruptions in treatment and fluctuating effects.

[0008] The efficacy is vaguely defined, lacks specificity, and is difficult to match with complex sub-health symptoms. Sub-health conditions are often characterized by a mixture of deficiency and excess, cold and heat, and multiple organ dysfunctions. Single-function products that tonify Qi, nourish Yin, dispel dampness, or calm the mind are insufficient to cover all symptoms, resulting in limited effectiveness and a high risk of relapse. For example, products that simply tonify Qi are suitable for Qi deficiency-type sub-health but not for those with Yin deficiency and excessive internal heat or dampness-heat; products that simply nourish Yin are suitable for Yin deficiency-type sub-health but not for those with spleen and stomach deficiency and dampness; and products that simply dispel dampness are suitable for those with excessive dampness but not for those with Qi and Yin deficiency or insufficient Qi and blood. The market lacks a comprehensive traditional Chinese medicine combination that simultaneously tonifies Qi and nourishes Yin, strengthens the spleen and dispels dampness, soothes the liver and regulates Qi, nourishes blood and calms the mind, moisturizes the skin and improves complexion, harmonizes Qi and blood, balances Yin and Yang, is mild in nature, safe and non-toxic, uses advanced technology, has a good taste, offers diverse dosage forms, and is suitable for long-term daily conditioning. This represents a critical technological bottleneck that urgently needs to be overcome in the field of sub-health management.

[0009] In summary, developing a traditional Chinese medicine composition that strictly adheres to the principles of traditional Chinese medicine (TCM) formulation, selects medicinal and edible ingredients, has a mild and balanced medicinal nature, employs advanced preparation processes, maintains a high retention rate of effective components, has good bioavailability, a pleasant taste, flexible dosage forms, is safe and non-toxic, is suitable for long-term use, and comprehensively improves complex sub-health symptoms has significant clinical value, social significance, and broad market prospects. Summary of the Invention

[0010] In view of this, the present invention provides a traditional Chinese medicine composition for regulating sub-health and its preparation method, so as to solve or alleviate one of the technical problems existing in the prior art, and at least provide a beneficial option.

[0011] The technical solution of this invention is implemented as follows: a traditional Chinese medicine composition for regulating sub-health and its preparation method, made from the following raw materials in parts by weight: Asparagus root 90-110 parts, lily bulb 90-110 parts, Poria cocos 90-110 parts, wheat bran 90-110 parts, Polygonatum sibiricum 45-55 parts, mulberry fruit 140-160 parts, black sesame 90-110 parts, walnut 75-85 parts, ginseng 90-110 parts, and wolfberry fruit 1. 40-160 parts, Angelica dahurica 12-18 parts, rose petals 90-110 parts, jujube 45-55 parts, honey 45-55 parts, Buddha's hand 90-110 parts, dried tangerine peel 190-210 parts, lotus seeds 75-85 parts, peach kernels 140-160 parts, Amomum villosum 45-55 parts, chrysanthemum 90-110 parts, hawthorn 140-160 parts, yam 90-110 parts, kudzu root 90-110 parts, coix seed 90-110 parts.

[0012] Furthermore, it also includes 5-10 servings of natural vitamin C.

[0013] Furthermore, it is made from the following ingredients in parts by weight: 105 parts Asparagus, 100 parts Lily bulb, 100 parts Poria cocos, 100 parts Wheat bran, 50 parts Polygonatum sibiricum, 150 parts Mulberry fruit, 100 parts Black sesame, 80 parts Walnut, 150 parts Goji berries, 15 parts Angelica dahurica, 100 parts Rose, 50 parts Jujube, 50 parts Honey, 100 parts Buddha's hand, 200 parts Dried tangerine peel, 80 parts Lotus seed, 150 parts Peach kernel, 50 parts Amomum villosum, 100 parts Chrysanthemum, 150 parts Hawthorn, 100 parts Dioscorea opposita, 100 parts Kudzu root, and 100 parts Coix seed.

[0014] Furthermore, it also includes 8 servings of natural vitamin C.

[0015] Furthermore, the following steps are included: (1) Raw material pretreatment: Weigh each medicinal material according to the weight parts, wash the asparagus, lily, white poria, floating wheat, wine-processed polygonatum, ginseng, wolfberry, angelica, Buddha's hand, tangerine peel, lotus seed, peach kernel, amomum, yam, kudzu root, coix seed, and hawthorn, dry them at low temperature, and pulverize them through an 80-120 mesh sieve to obtain the first mixed fine powder; roast black sesame and walnuts at low temperature until crisp, and pulverize them into fine powder to obtain the second mixed fine powder; remove impurities from rose and chrysanthemum, pulverize them through a 60 mesh sieve to obtain the third mixed fine powder; remove the pits from jujubes, dry and pulverize them to obtain jujube powder; (2) Mixing and blending: Mix the first fine powder, the second fine powder, the third fine powder and the jujube powder obtained in step (1) evenly, add honey and stir until fully blended; if natural vitamin C is added, add it at this stage and continue to mix evenly to obtain the mixture. (3) Shaping and drying: The mixture is made into pills, granules, powders, ointments or oral liquids, dried at low temperature or sterilized and then packaged to obtain the finished Chinese medicine composition.

[0016] Furthermore, the temperature of the low-temperature drying in step (1) is 50-60℃.

[0017] Furthermore, in step (1), the low-temperature baking temperature for black sesame seeds and walnuts is 60℃.

[0018] Furthermore, when the dosage form is pills, granules, powders or ointments, the low-temperature drying temperature in step (3) is 40-50℃, and the moisture content of the material after drying is ≤8%; the sterilization method is ultraviolet sterilization.

[0019] Furthermore, when the dosage form is an oral liquid, step (3) specifically includes the following sub-steps: (3-1) Water extraction and concentration: The first mixed fine powder, the second mixed fine powder, the third mixed fine powder and jujube powder are put into the extraction tank, 8-10 times the amount of purified water is added, soaking for 30-60 minutes, heated to a slight boil and extracted twice, each time for 11.5 hours, the extracts are combined, filtered, and concentrated under reduced pressure below 60°C to a clear extract with a relative density of 1.10-1.15. (3-2) Alcohol precipitation purification: Add ethanol to the clear extract to a content of 60%-70% alcohol, let it stand at 48°C for 24-48 hours, take the supernatant to recover the ethanol, and concentrate under reduced pressure to a fluid extract with a relative density of 1.05-1.08. (3-3) Preparation and volume adjustment: Add the honey, natural vitamin C and purified water to the fluid extract, stir well, adjust the pH value to 5.5~6.5 with pH adjuster, add purified water to the specified volume, add 0.1%~0.3% natural flavoring agent, and mix well; (3-4) Filtration and filling: The drug solution is filtered through a 0.22μm microporous membrane, filled and sterilized, and packaged after passing the light inspection to obtain the finished oral liquid product.

[0020] Furthermore, the natural flavoring agent mentioned in step (3-3) is one or a combination of steviol glycoside and xylitol, and the pH adjuster is citric acid or sodium bicarbonate; the sterilization method in step (3-4) is moist heat sterilization at 115℃ for 20~30min.

[0021] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions: This invention strictly adheres to the holistic concept and syndrome differentiation and treatment theory of Traditional Chinese Medicine, constructing a three-dimensional formulation system of "principal herbs tonifying qi and nourishing yin, assistant herbs strengthening the spleen and tonifying the liver and kidneys, adjuvant herbs regulating qi, promoting blood circulation and removing dampness, and guiding herbs harmonizing all herbs": The principal herbs (ginseng, asparagus, lily bulb, and wine-processed polygonatum) tonify qi and nourish yin, generate fluids and moisten dryness, and calm the mind and stabilize the will, directly targeting the core pathogenesis of qi and yin deficiency; The assistant herbs (goji berry, mulberry, yam, lotus seed, white poria, and coix seed) nourish the liver and kidneys, strengthen the spleen and remove dampness, and nourish the heart and calm the mind. This formula nourishes both the innate and acquired constitution, strengthening the body's foundation. The adjuvant herbs (Buddha's Hand, Tangerine Peel, Amomum villosum, Peach Kernel, Hawthorn, Kudzu Root, Angelica dahurica, Chrysanthemum, Rose, and Wheat Wheat) soothe the liver and regulate qi, invigorate blood circulation, promote digestion, clear heat and release the exterior, strengthen the exterior and stop sweating, relieve depression and calm the mind, addressing concurrent symptoms such as qi stagnation, blood stasis, food stagnation, internal heat, and restlessness. The guiding herbs (Jujube, Honey, Black Sesame, and Walnut) harmonize the other herbs, replenish qi and blood, nourish blood and moisten dryness, tonify the kidneys and replenish essence, and improve taste. The entire formula contains 24 medicinal and edible ingredients, meticulously combined, employing both tonifying and purging methods, maintaining a balance of warming and cooling properties, and regulating the ascending and descending functions. It simultaneously regulates the five major systems of the nervous, digestive, endocrine, immune, and skin systems, comprehensively improving complex sub-health symptoms such as insomnia, fatigue, loss of appetite, dampness, emotional distress, and dull skin, with significantly better effects than single-effect products.

[0022] All raw materials used in this invention are selected from the National Health Commission's list of medicinal and edible homologous ingredients, containing no toxic, harmful, or prohibited medicinal materials, ensuring safety from the source. The formula scientifically combines warming medicinal materials (ginseng, walnut, dried tangerine peel, cardamom, jujube, honey) with cooling medicinal materials (asparagus, lily, chrysanthemum, kudzu root, mulberry), providing warmth without being overly drying and cooling without harming the stomach. A large number of nourishing medicinal materials are combined with qi-regulating, blood-activating, and digestion-aiding agents, ensuring nourishment without stagnation, sustenance without being greasy, warmth without being hot, and cooling without being cold, completely solving the problems of traditional tonics such as "inability to tolerate tonics, abdominal distension and internal heat, and cold-induced diarrhea." Long-term human trials have shown that men, women, children, the elderly, young professionals, middle-aged people under high pressure, the elderly with weak constitutions, and those with constitutions that are either cold or hot can all take this product long-term without liver or kidney damage, dependence, drug resistance, or significant adverse reactions, demonstrating extremely high safety.

[0023] This invention innovatively designs four core processes targeting the physicochemical properties of different medicinal materials: classification pretreatment, low-temperature control throughout the process, gradient pulverization, and honey coupling. These processes solve the problems of loss of effective ingredients and poor absorption in traditional methods: ① Classification pretreatment: Roots and rhizomes (ginseng, kudzu root, yam) are dried at 50-60℃ and ground into 80-120 mesh fine powder, resulting in high cell wall breakage rate and easy dissolution of effective ingredients; Seeds (black sesame, walnut) are roasted at 60℃ to enhance aroma and protect unsaturated fatty acids and vitamins from oxidation; Flowers (rose, chrysanthemum) are pulverized at 60 mesh after impurity removal to fully retain volatile oils and flavonoid active ingredients; Fruits (jujube, hawthorn, mulberry) are dried and pulverized at low temperature to retain vitamins, organic acids, and anthocyanins. ② Low-temperature process throughout: Raw material drying (50-60℃), baking (60℃), and finished product drying (40-50℃) are all carried out at temperatures ≤60℃. This ensures that the retention rate of heat-sensitive active ingredients (saponins, polysaccharides, flavonoids, volatile oils, and vitamins) reaches over 95%, far exceeding that of traditional high-temperature processes. ③ Honey coupling: Honey acts as a natural binder, carrier, and nutrient, improving the taste while promoting the dissolution, absorption, and transport of the active ingredients in the medicinal materials within the intestines, increasing bioavailability by over 30%.

[0024] This invention features a highly versatile formula. The same raw material system can be flexibly formulated into five dosage forms—pills, granules, powders, ointments, and capsules—by adjusting the molding process, catering to different age groups, lifestyles, and usage scenarios: pills offer sustained release, are convenient to carry, and are suitable for daily long-term use; granules are quick-dissolving and easy to mix, with a sweet taste, suitable for office workers, students, and frequent travelers; powders have ultra-fine particle size, require no disintegration, and are absorbed most quickly, suitable for those with weak spleen and stomach or poor digestion; ointments are gentle and nourishing, with a rich taste, suitable for the elderly and those with weak constitutions, and for women seeking beauty and conditioning; capsules are portable and tasteless, suitable for those sensitive to taste. All process parameters (temperature, mesh size, moisture content, sterilization dosage) are quantified and standardized, facilitating automated, large-scale, and industrialized production. Batch-to-batch quality is stable with minimal variation, quality control is manageable, and it is suitable for large-scale promotion and application.

[0025] This invention overcomes the drawbacks of traditional Chinese medicine's bitterness and unpleasant smell, utilizing the sweetness of jujubes, the richness of honey, the fragrance of roses, the aroma of black sesame and walnuts, and the sweet and sour taste of mulberries and hawthorns to create a naturally pleasant sensory experience. It has a moderate sweetness, rich aroma, no obvious bitterness, no off-flavors, and no stickiness. The original paste-like material has a mild and sweet taste; the granules and powder, after being mixed with water, are pleasantly fragrant; and the pills are small and easy to swallow, greatly improving compliance. It is especially suitable for young women, children (as directed by a physician), the elderly, and those sensitive to taste for long-term use, completely solving the industry pain point of functional foods being "effective but difficult to swallow."

[0026] This invention does not simply alleviate surface symptoms, but addresses the root cause of the disease in Traditional Chinese Medicine (TCM). It replenishes Qi and blood, regulates Yin and Yang, strengthens the spleen and stomach, soothes liver stagnation, calms the mind, eliminates dampness and turbidity, and invigorates Qi and blood. It repairs damaged organ functions, balances the disordered internal environment, and enhances the body's immunity and self-repair capabilities. Short-term use can quickly improve symptoms such as fatigue, insomnia, loss of appetite, irritability, and dull skin. Long-term use can consolidate the therapeutic effect, improve physical condition, reduce symptom recurrence, and prevent sub-health from transforming into chronic diseases. It achieves both symptomatic and root-cause treatment, with lasting effects and low relapse rates, unlike the limitations of Western medicine which only provides symptomatic relief and causes rebound upon discontinuation.

[0027] The raw materials used in this invention are all natural food and medicine ingredients, rich in ginsenosides, polygonatum polysaccharides, lily polysaccharides, wolfberry polysaccharides, flavonoids, volatile oils, unsaturated fatty acids, vitamins, minerals, amino acids, dietary fiber and other active nutritional components. It not only has the conditioning effects of traditional Chinese medicine, but also the nourishing nutritional value of natural food ingredients. It can supplement the nutrients lacking in daily diet, enhance physical fitness, and improve nutritional imbalance. It is suitable for long-term consumption as a daily health food, achieving the triple value of "conditioning sub-health + supplementing nutrition + improving physical fitness".

[0028] This invention has a mild medicinal property, no obvious hot or cold properties, no contraindications, and no special restrictions on use. It is suitable for various sub-healthy people, daily health maintenance for healthy people, conditioning for people with weak constitutions, and recovery for people after illness. Applicable scenarios cover family health maintenance, workplace health care, women's beauty care, elderly tonics, children's constitution conditioning (as directed by a doctor), stress reduction and calming for people with high pressure, etc. It has a high cost-performance ratio, is affordable, and has a low economic burden for long-term use, making it easy for the public to accept and promote.

[0029] More flexible dosage form options to meet the needs of the entire population: In addition to the existing pills, granules, powders, and ointments, an oral liquid dosage form has been added. The oral liquid is refined by water extraction and alcohol precipitation, with fewer impurities and more complete dissolution of active ingredients. It can be directly absorbed after oral administration without disintegration, and its onset of action is faster than that of solid dosage forms. It is especially suitable for children, the elderly, postoperative recovery groups, and people who need to quickly improve symptoms of insomnia and fatigue in a short period of time. At the same time, natural flavoring agents are used to adjust the taste, eliminating the bitterness of traditional Chinese medicine decoctions, further improving the compliance of users.

[0030] The above overview is for illustrative purposes only and is not intended to be limiting in any way. Further aspects, embodiments, and features of the invention will become apparent from the following detailed description, in addition to the illustrative aspects, embodiments, and features described above. Detailed Implementation

[0031] Example 1: Traditional Chinese Medicine Composition (Pills) for Treating Sub-health 1. Raw material formula (parts by weight / unit: g) Asparagus 105 roses 100 lily 100 jujube 50 Poria cocos 100 Honey 50 floating wheat 100 Buddha's Hand 100 Wine-processed Polygonatum 50 Dried tangerine peel 200 Mulberry 150 lotus seeds 80 Black sesame 100 peach kernel 150 Walnut 80 Amomum villosum 50 Ginseng 100 chrysanthemum 100 Goji berries 150 hawthorn 150 Angelica dahurica 15 yam 100 Kudzu root 100 Job's tears 100 Natural Vitamin C 8 - - 2. Preparation process 1) Raw material screening and cleaning: Weigh each raw material according to the table above, remove moldy, insect-infested, and impurities, rinse quickly with clean water, and drain the surface moisture.

[0032] 2) Low-temperature drying and pulverization: Rhizomes and hard medicinal materials (Asparagus, Lily, Poria cocos, Wheat, Polygonatum sibiricum, Ginseng, Lycium barbarum, Angelica dahurica, Citrus medica, Tangerine peel, Lotus seed, Peach kernel, Amomum villosum, Dioscorea opposita, Kudzu root, Coix seed, Hawthorn): Dry at 55℃ for 3.5h, moisture content ≤6%, pulverize and pass through a 100-mesh sieve to obtain fine powder A.

[0033] Black sesame seeds and walnuts: Roast at 60℃ for 25 minutes until crispy, cool and grind to obtain fine powder B.

[0034] Roses and chrysanthemums: Remove impurities, air dry, pulverize and pass through a 60-mesh sieve to obtain fine powder C.

[0035] Jujubes: Remove the pits, dry them, and grind them through an 80-mesh sieve to obtain jujube powder.

[0036] 3) Mixing and preparing the paste: Mix fine powders A, B, and C (jujube powder) evenly, add honey and stir for 30 minutes, then add natural vitamin C and mix well to obtain a brown paste.

[0037] 4) Pelletizing and drying: Prepare small pellets with a diameter of about 6mm, dry at 45℃ for 3 hours, control the moisture content to 6%, sterilize with ultraviolet light for 30 minutes, and package to obtain the finished product.

[0038] Appearance Small, round, brownish-brown pellets with a delicate fragrance and a sweet, slightly bitter taste. Round, unbroken, and with uniform color Moisture (%) 6.1 ≤8.0 Difference in pellet weight (%) ±4.2 ±5.0 Total flavonoids (%) 1.92 ≥1.5 Polysaccharides (%) 3.15 ≥2.5 Microbial limits (CFU / g) ＜80 ≤1000 4. Method of administration and effects Dosage: Take 10 pills twice daily with warm water for 30 days as one cycle.

[0039] Typical improvements: Improvement rate of symptoms such as insomnia, fatigue, irritability, loss of appetite, and dull skin >90%.

[0040] Example 2: Traditional Chinese Medicine Composition for Treating Sub-health (Granules) 1. Raw material formula (parts by weight / unit: g) Asparagus 98 roses 98 lily 98 jujube 49 Poria cocos 102 Honey 49 floating wheat 102 Buddha's Hand 98 Wine Polygonatum 49 Dried tangerine peel 198 Mulberry 148 lotus seeds 79 Black sesame 98 peach kernel 148 Walnut 79 Amomum villosum 49 Ginseng 98 chrysanthemum 98 Goji berries 148 hawthorn 148 Angelica dahurica 14.5 yam 98 Kudzu root 98 Job's tears 102 2. Preparation process 1) Raw material pretreatment: screening, washing, draining, drying, baking, crushing and sieving according to category, with operating parameters the same as in Example 1.

[0041] 2) Mixing to make soft material: Mix all kinds of fine powders thoroughly, add honey and stir for 25 minutes to make a soft material that is moderately soft and loose and not sticky.

[0042] 3) Granulation and drying: 14-mesh shaking granulation, drying at 42℃ for 2.8h, granulation, 12-1 mesh screening, ultraviolet sterilization, and packaging into 10g / bag granules.

[0043] Appearance Brown granules, loose and uniform, with a light and slightly sweet aroma. Uniform, without lumps or burnt residue Moisture (%) 5.7 ≤8.0 Particle size compliance rate (%) 98.3 ≥95 Solubility Completely dissolved, no precipitate. It should be completely melted. Total saponins (%) 2.45 ≥2.0 Microbial limits (CFU / g) ＜70 ≤1000 4. Method of administration and effects Dosage: Take 1 sachet twice daily, dissolved in warm water.

[0044] Typical improvements: Fatigue, excessive dampness, mood swings, and indigestion improved by more than 88%, making it suitable for long-term consumption by office workers.

[0045] Example 3: Traditional Chinese Medicine Composition (Powder) for Treating Sub-health 1. Raw material formula (parts by weight / unit: g) Asparagus 102 roses 102 lily 102 jujube 51 Poria cocos 98 Honey 51 floating wheat 98 Buddha's Hand 102 Wine-processed Polygonatum 51 Dried tangerine peel 202 Mulberry 152 lotus seeds 81 Black sesame 102 peach kernel 152 Walnut 81 Amomum villosum 51 Ginseng 102 chrysanthemum 102 Goji berries 152 hawthorn 152 Angelica dahurica 15.5 yam 102 Kudzu root 102 Job's tears 98 Natural Vitamin C 9 - - 2. Preparation process 1) Raw material pretreatment: screening, washing, and draining; root vegetables are dried at 58℃ for 3 hours and pulverized through 120 mesh; black sesame seeds and walnuts are baked at 60℃ for 25 minutes; flowers are pulverized at low temperature to 60 mesh; jujubes are dried, pulverized, and set aside.

[0046] 2) Mixing: Mix all kinds of fine powders for 25 minutes, add honey and stir well, then add vitamin C and mix well to obtain a paste.

[0047] 3) Low-temperature drying and ultra-fine pulverization: vacuum drying at 40℃ for 3.5h, moisture content ≤6%; ultra-fine pulverization through a 120-mesh sieve, packaged as 5g / bag powder, and sterilized by ultraviolet light.

[0048] Appearance Brownish-brown ultrafine powder, fine and even, with a rich aroma Fine, without lumps, and free of impurities Moisture (%) 5.9 ≤8.0 Fineness pass rate (%) 99.1 ≥98 Total flavonoids (%) 2.15 ≥1.5 Polysaccharides (%) 3.60 ≥2.5 Microbial limits (CFU / g) ＜60 ≤1000 4. Method of administration and effects Dosage: Take 1 sachet twice daily, dissolved in warm water or milk.

[0049] Typical improvements: Improvement rate of >92% for weak spleen and stomach, physical weakness and fatigue, insomnia, and low immunity; fast absorption and quick results.

[0050] Example 4: Traditional Chinese Medicine Composition for Treating Sub-health (Oral Liquid) 1. Raw material formula (parts by weight / unit: g) Asparagus 105 roses 100 lily 100 jujube 50 Poria cocos 100 Honey 50 floating wheat 100 Buddha's Hand 100 Wine Polygonatum 50 Dried tangerine peel 200 Mulberry 150 lotus seeds 80 Black sesame 100 peach kernel 150 Walnut 80 Amomum villosum 50 Ginseng 100 chrysanthemum 100 Goji berries 150 hawthorn 150 Angelica dahurica 15 yam 100 Kudzu root 100 Job's tears 100 Natural Vitamin C 8 — — 2. Preparation process (1) Raw material pretreatment: Same as steps 1-2 in Example 1, to obtain the first mixed fine powder, the second mixed fine powder, the third mixed fine powder and jujube powder; (2) Water extraction and concentration: Put all the above fine powders into the extraction tank, add 10 times the amount of purified water, soak for 45 min, heat to a gentle boil and extract twice, 1.2 h each time, filter through a 200 mesh sieve, combine the filtrates, and concentrate under reduced pressure at 55℃ to a clear extract with a relative density of 1.12 (60℃). (3) Alcohol precipitation and purification: Slowly add 95% ethanol to the clear extract, stir until the alcohol content is 65%, transfer to a stainless steel bucket, refrigerate at 4°C for 36 hours, siphon off the supernatant, recover the ethanol under reduced pressure until there is no alcohol odor, and concentrate to a fluid extract with a relative density of 1.06 (60°C). (4) Solution preparation: Add honey, natural vitamin C and 0.2g steviol glycoside to the fluid extract, adjust the pH to 6.0 with citric acid, add purified water to a total volume of 1000mL, and stir for 30min until completely mixed; (5) Filtration and filling: The medicine is filtered through a 0.22μm polyethersulfone filter membrane, filled into 10mL brown oral liquid bottles, sterilized by high-pressure steam at 116℃ for 25min, and unqualified products with leakage, turbidity and precipitation are removed by light inspection. The finished product is then labeled and boxed.

[0051] Appearance A clear, brownish-yellow liquid; a small amount of easily dispersed sediment may form upon prolonged standing; it has a sweet, slightly fragrant taste. Clear and free of foreign matter pH value 5.9 5.5~6.5 relative density 1.05 ≥1.02 Total saponin content (calculated as ginsenoside Re) 1.8 mg / mL ≥1.2mg / mL Microbial limits (CFU / mL) <10 ≤100 Heavy metals (as Pb) <0.1mg / kg ≤0.3mg / kg 4. Method of administration and effects Dosage: Take 1 vial twice daily, orally, for 15 days as one cycle. Typical improvements: Improvement rate of over 93% in difficulty falling asleep, morning fatigue, and anxiety. The onset time is 3-5 days shorter than that of pills, making it suitable for short-term intensive conditioning during periods of high stress.

[0052] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. A traditional Chinese medicine composition for regulating sub-health and its preparation method, characterized in that: Made from the following ingredients by weight: Asparagus root 90-110 parts, Lily bulb 90-110 parts, Poria cocos 90-110 parts, Wheat bran 90-110 parts, Polygonatum sibiricum 45-55 parts, Mulberry fruit 140-160 parts, Black sesame seeds 90-110 parts, Walnuts 75-85 parts, Ginseng 90-110 parts, Goji berries 140-160 parts, Angelica dahurica 12-18 parts, Rose Flower 90-110 parts, Jujube 45-55 parts, Honey 45-55 parts, Buddha's Hand 90-110 parts, Dried Tangerine Peel 190-210 parts, Lotus Seed 75-85 parts, Peach Kernel 140-160 parts, Amomum 45-55 parts, Chrysanthemum 90-110 parts, Hawthorn 140-160 parts, Yam 90-110 parts, Kudzu Root 90-110 parts, Job's Tears 90-110 parts.

2. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 1, characterized in that: It also includes 5-10 servings of natural vitamin C.

3. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 1, characterized in that: Made from the following ingredients in parts by weight: Asparagus 105 parts, Lily bulb 100 parts, Poria cocos 100 parts, Wheat bran 100 parts, Polygonatum sibiricum 50 parts, Mulberry fruit 150 parts, Black sesame 100 parts, Walnut 80 parts, Goji berry 150 parts, Angelica dahurica 15 parts, Rose 100 parts, Jujube 50 parts, Honey 50 parts, Buddha's hand 100 parts, Dried tangerine peel 200 parts, Lotus seed 80 parts, Peach kernel 150 parts, Amomum villosum 50 parts, Chrysanthemum 100 parts, Hawthorn 150 parts, Chinese yam 100 parts, Kudzu root 100 parts, and Coix seed 100 parts.

4. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 3, characterized in that: It also includes 8 servings of natural vitamin C.

5. A traditional Chinese medicine composition for regulating sub-health and its preparation method according to any one of claims 1 to 4, characterized in that: Includes the following steps: (1) Raw material pretreatment: Weigh each medicinal material according to the weight parts, wash the asparagus, lily, white poria, floating wheat, wine-processed polygonatum, ginseng, wolfberry, angelica, Buddha's hand, tangerine peel, lotus seed, peach kernel, amomum, yam, kudzu root, coix seed, and hawthorn, dry them at low temperature, and pulverize them through an 80-120 mesh sieve to obtain the first mixed fine powder; roast black sesame and walnuts at low temperature until crisp, and pulverize them into fine powder to obtain the second mixed fine powder; remove impurities from rose and chrysanthemum, pulverize them through a 60 mesh sieve to obtain the third mixed fine powder; remove the pits from jujubes, dry and pulverize them to obtain jujube powder; (2) Mixing and blending: Mix the first fine powder, the second fine powder, the third fine powder and the jujube powder obtained in step (1) evenly, add honey and stir until fully blended; if natural vitamin C is added, add it at this stage and continue to mix evenly to obtain the mixture. (3) Shaping and drying: The mixture is made into pills, granules, powders, ointments or oral liquids, dried at low temperature or sterilized and then packaged to obtain the finished Chinese medicine composition.

6. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 5, characterized in that: The temperature of the low-temperature drying in step (1) is 50-60℃.

7. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 5, characterized in that: In step (1), the low-temperature baking temperature for black sesame seeds and walnuts is 60℃.

8. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 5, characterized in that: When the dosage form is pills, granules, powder or ointment, the low temperature drying temperature in step (3) is 40-50℃, and the moisture content of the material after drying is ≤8%; the sterilization method is ultraviolet sterilization.

9. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 5, characterized in that: When the dosage form is an oral liquid, step (3) specifically includes the following sub-steps: (3-1) Water extraction and concentration: The first mixed fine powder, the second mixed fine powder, the third mixed fine powder and jujube powder are put into the extraction tank, 8-10 times the amount of purified water is added, soaking for 30-60 minutes, heated to a slight boil and extracted twice, each time for 11.5 hours, the extracts are combined, filtered, and concentrated under reduced pressure below 60°C to a clear extract with a relative density of 1.10-1.

15. (3-2) Alcohol precipitation purification: Add ethanol to the clear extract to a content of 60%-70% alcohol, let it stand at 48°C for 24-48 hours, take the supernatant to recover the ethanol, and concentrate under reduced pressure to a fluid extract with a relative density of 1.05-1.

08. (3-3) Preparation and volume adjustment: Add the honey, natural vitamin C and purified water to the fluid extract, stir well, adjust the pH value to 5.5~6.5 with pH adjuster, add purified water to the specified volume, add 0.1%~0.3% natural flavoring agent, and mix well; (3-4) Filtration and filling: The drug solution is filtered through a 0.22μm microporous membrane, filled and sterilized, and packaged after passing the light inspection to obtain the finished oral liquid product.

10. The traditional Chinese medicine composition for regulating sub-health and its preparation method according to claim 9, characterized in that: The natural flavoring agent mentioned in step (3-3) is one or a combination of steviol glycoside and xylitol, and the pH adjuster is citric acid or sodium bicarbonate; the sterilization method in step (3-4) is moist heat sterilization at 115℃ for 20~30min.