Sulforaphane and platinum medicine anti-cancer combination preparation

A technology of sulforaphane and platinum, applied in the field of pharmaceutical preparations used in tumor treatment, to achieve the effect of enhancing the curative effect

Inactive Publication Date: 2008-04-30
BEIJING TUBERCULOSIS & THORACIC TUMOR RES INST
View PDF0 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although there are many studies on the combined drug or combined preparation with cisplatin, it is still necessary to find a combined drug and combined preparation with stronger synergistic effect and reduced side effects.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sulforaphane and platinum medicine anti-cancer combination preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention will be further clarified through the detailed description of specific embodiments below in conjunction with the accompanying drawings, but it is not intended to limit the present invention, but only for illustration.

[0019] 1. Materials and methods

[0020] 1. Experimental cell line: Human lung adenocarcinoma cell line LTEP-A2 was established by our laboratory (Wang Hui, Lai Baitang, Zhan Xiuping et al., Establishment of two human lung adenocarcinoma cell lines and observation of their biological characteristics Chinese Journal of Oncology 1983, 5(2):85-88). The cells were maintained in RPMI-1640 (GIBCO) culture medium containing 20% ​​fetal bovine serum, digested with 0.25% trypsin and 0.02% EDTA and then subcultured.

[0021] 2. In vitro inhibition test of DDP and SFN on A2 cells: A2 cells in the logarithmic growth phase were digested into single cells, and seeded in 35mm-diameter dishes, with 500 cells per dish. After dissolving DDP and SFN...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
control rateaaaaaaaaaa
Login to view more

Abstract

The anti-cancer combined preparation containing sulforaphane and platinum drugs is used for the treatment of cancer, especially lung cancer, and the components can be administered simultaneously, separately or sequentially. Among them, sulforaphane increases the anticancer effect of platinum anticancer drugs.

Description

technical field [0001] The invention relates to the field of medicine, in particular to pharmaceutical preparations used in tumor treatment. Background technique [0002] In the past 30 years, the incidence and mortality of lung cancer in my country have shown a continuous upward trend, and the high-incidence cancer spectrum in my country has also shown an obvious trend of change. In the 1970s, the main tumors were gastric cancer, esophageal cancer, liver cancer, lung cancer, and cervical cancer. In 2000, they evolved into lung cancer, liver cancer, gastric cancer, esophageal cancer, and colorectal cancer. The mortality rate decreased most obviously for cervical cancer, and the most obvious increase was for lung cancer. In many areas, especially in cities, lung cancer has become the No. 1 cause of death. In the next 20 to 30 years, my country's cancer mortality rate will continue to rise, and will become a major problem in disease prevention and control. [0003] Cisplati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K31/282A61P35/00A61K31/26
Inventor 赖百塘汪惠
Owner BEIJING TUBERCULOSIS & THORACIC TUMOR RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap