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Method for preparing curcumin polymer

A technology of curcumin and polymer, applied in the field of preparation of curcumin polymer, can solve the problems such as the inability of the drug to reach the tumor position, the poor loading efficiency and loading capacity, and the influence on the anti-cancer performance, so as to improve the stability and bioavailability. , easy to operate, improve the effect of cytotoxicity and anti-cancer ability

Inactive Publication Date: 2010-01-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the load efficiency and load capacity of these methods are very poor, so a large amount of carrier materials must be used in application.
In addition, the drugs obtained by these methods have poor stability in the blood, which may cause violent release, resulting in the inability of the drugs to reach the tumor site and affecting their anticancer properties.

Method used

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  • Method for preparing curcumin polymer
  • Method for preparing curcumin polymer
  • Method for preparing curcumin polymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 2.000g of curcumin and 1.183g of pyromellitic anhydride were dissolved in 50ml of DMSO, reacted at 50°C for 24 hours, the product was precipitated with THF, and washed to obtain curcumin pyromellitic acid polymer. This polymer 1g is dissolved in 40ml DMSO, adds 2g monomethoxypolyethylene glycol (number average molecular weight Mn=1100), 2.5g DCC and 0.2g DMAP, reacts after 24 hours, precipitates with anhydrous ether, obtains 2.2 g of the final product having the following structure, yield 74%.

[0025]

[0026] In the above structural formula, m=24.5, 5<n<100.

Embodiment 2

[0028] Except that diethylenetriaminepentaacetic dianhydride was used instead of pyromellitic anhydride, the rest of the operations were the same as in Example 1 to obtain 2.3 g of the final product with the following structural formula, with a yield of 75%.

[0029]

[0030]In the above structural formula, m=24.5, 5<n<100.

Embodiment 3

[0032] Except that cyclobutanetetracarboxylic dianhydride was used instead of pyromellitic anhydride, the rest of the operations were the same as in Example 1 to obtain 2.0 g of the final product with the following structural formula, with a yield of 70%.

[0033]

[0034] In the above structural formula, m=24.5, 5

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Abstract

The invention discloses a method for preparing curcumin polymer, which comprises the following steps: dissolving curcumin and a monomer into organic solvent to carry out condensation polymerization under the action of a catalyst at 0-100 DEG C for 1 hour to 48 hours and carrying out purification processing to obtain a curcumin polymer, wherein the monomer is one or more of diacid monomer, anhydride monomer, dichloride monomer, diene monomer and diol monomer. The method is simple and has convenient operation, and the prepared and obtained curcumin polymer has favorable thermal stability, storage stability and controllable molecular weight and degradation rate; compared with curcumin, the curcumin polymer not only obviously improves the stability and the biological utilization ratio of the curcumin, but also obviously improves the cytotoxicity and the cancer resistance of the curcumin on cancer cells.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a preparation method of curcumin polymer. Background technique [0002] Curcumin, namely (E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is a Hydrophobic polyphenols extracted from the underground roots of the perennial herb Curcuma longa. In ancient India and China, curcumin was used as a food spice. In traditional Chinese medicine, curcumin is used as a wound healing and liver disease remedy. [0003] Recently, it has been found that curcumin has various biological and pharmacological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, anticancer and anticancer effects, etc. Curcumin has received a lot of attention due to its unique anti-cancer and anti-cancer effects. As an antioxidant, curcumin can inhibit cell proliferation and is expected to become a new anticancer drug. It has been reported that curcumin ca...

Claims

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Application Information

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IPC IPC(8): C08G63/676C08G63/91C08G63/685C08G63/688C08G65/40A61K31/765A61P35/00
Inventor 申有青唐建斌隋梅花黄金强
Owner ZHEJIANG UNIV
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