The invention relates to the technical field of orthopedic disease treatment, and discloses an external preparation for treating orthopedic disease, comprising the following raw materials in parts byweight: Angelica sinensis 12-20 part, szechwan lovage rhizome 6-12 part, chinaroot greenbrier 5-10 parts, ephedra 4-8 part, polygonum cuspidatum 5-10 part, liquorice 10-20 parts, safflower 8-16 parts,teasel root 6-12 parts, Turpinia formosana 3-6 part, Rabdosia rubescens 2-6 portions, Saposhnikovia divaricata 5-10 parts, lotus leaf 3-6, angelica 4-8 part, tortoise shell 2-6 part, nutgall 2-5 part, red halloysite 1-2 part, salicylic acid 2-5 part, diclofenac 2-5 part, allopurinol 2-4 part, borneol 1-3 part, film forming auxiliary agent 20-30 part. The invention also discloses a preparation method of the external preparation for treating orthopedic diseases. The external preparation prepared by the invention has good curative effect on orthopedic diseases under the combined action of various raw materials.