The invention discloses a traditional Chinese medicine composition for preventing restenosis after percutaneous coronary intervention. The traditional Chinese medicine preparation is prepared from the following raw medicines: sapanwood, valerian, Chinese rose, dioscorea nipponica, pummelo flower, sargentg loryvine, motherwort, forsythia, auriculate swallowwort root and longflower stringbush root. The traditional Chinese medicine composition for preventing restenosis after percutaneous coronary intervention, provided by the invention, is capable of reducing the death rate, relieving symptoms, reducing restenosis occurrence, improving the life quality of patients, reducing the treatment cost and ensuring that the patient dependence is good. By adopting a water decoction of the traditional Chinese medicine composition for preventing restenosis after percutaneous coronary intervention, provided by the invention, for treating 40 patients for six months, the restenosis rate of a treatment group is 12.50%, and the restenosis rate of a control group is 32.50%, so that the restenosis rate of the treatment group is obviously lower than the restenosis rate of the control group, wherein P is less than 0.05.