Example systems and techniques are disclosed that may determine at least one
treatment strategy for a
lesion. An example
system may include memory configured to store clinical guidance and / or
informatics for a PCI procedure and
processing circuitry communicatively coupled to the memory. The
processing circuitry may be configured to determine the plurality of treatment pathways. The
processing circuitry may be configured to obtain angiogram
imaging data of a coronary vasculature of a patient. The processing circuitry may be configured to determine the clinical guidance and / or
informatics based at least in part on the angiogram
imaging data. The processing circuitry may be configured to output for display the angiogram
imaging data and at least a portion of the clinical guidance and / or
informatics, wherein the at least a portion of the clinical guidance and / or informatics is overlaid onto the angiogram imaging data.