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Biomarker for predicting vascular restenosis and test kit

A biomarker, restenosis technology, applied in the direction of biological material analysis, measurement devices, instruments, etc., can solve the problems of increasing the risk factors of ISR, reducing the incidence rate, etc., and achieve the effect of preventing vascular restenosis with high accuracy

Active Publication Date: 2019-07-30
BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Problems solved by technology

[0002] Coronary heart disease is one of the most important death diseases in human beings. Percutaneous coronary angioplasty (PCI) has been widely used, but restenosis has always been a bottleneck restricting the development of coronary interventional surgery. Drug stent (DES) and Compared with bare metal stents, it significantly reduces the incidence of in-stent restenosis (ISR) after PCI, but DES also delays the repair of vascular endothelialization while preventing ISR, thus increasing the risk factors for ISR

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  • Biomarker for predicting vascular restenosis and test kit
  • Biomarker for predicting vascular restenosis and test kit
  • Biomarker for predicting vascular restenosis and test kit

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Embodiment Construction

[0039] The technical solutions and beneficial effects of the present invention will be further described below in conjunction with specific embodiments.

[0040] Such as figure 1As shown, 400 patients with coronary heart disease (CAD) were selected from January 2013 to December 2013. Coronary angiography (CAG) and stent implantation (PCI) were performed after admission, and serum was drawn for reexamination 1 month later. 6 Coronary angiography was performed one month later. Exclusion criteria were as follows: active inflammation (C-reactive protein [CRP] > 1.0 mg / dL), renal disease (serum creatinine > 3.0 mg / dL or on hemodialysis), cancer onset in the past 5 years, coronary artery bypass surgery (CABG), contraindicated in iodine allergy and severe hepatic insufficiency. Among them, 36 cases had restenotic lesions (≥50% stenosis), and this group of patients was defined as the sample group. Thirty-eight sex- and age-matched patients were then selected from other cases (less ...

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Abstract

The invention provides application of a biomarker to preparation of a kit for predicting restenosis after stent-interventional surgery and a relevant test kit. The biomarker comprises ceramide d18:1 / 18:2, sphingomyelin SM d18:1 / 20:0, sphingomyelin SM d18:1 / 18:2, lecithin PC 18:2 / 20:4, sphingosine 1-phosphate ester and phosphatidylserine PS18:1 / 18:1. As prediction of in-stent restenosis of patientswho suffer from coronary artery diseases after percutaneous coronary intervention (PCI), the biomarker can reduce the probability of occurrence of the in-stent restenosis, and has the advantages of non-invasiveness, high correctness, early stage, high accuracy.

Description

technical field [0001] The invention relates to the field of cardiovascular treatment and diagnosis, in particular to a biomarker for predicting vascular restenosis and its application. Background technique [0002] Coronary heart disease is one of the most important death diseases in human beings. Percutaneous coronary angioplasty (PCI) has been widely used, but restenosis has always been a bottleneck restricting the development of coronary interventional surgery. Drug stent (DES) and Compared with bare metal stents, it significantly reduces the incidence of in-stent restenosis (ISR) after PCI, but DES also delays the repair of vascular endothelialization while preventing ISR, thus increasing the risk factors for ISR. [0003] Metabolomics is another important branch of systems biology after genomics, transcriptomics and proteomics. Apply technologies such as high-throughput detection and multivariate data analysis to study all small-molecular-weight metabolites of organis...

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Application Information

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IPC IPC(8): G01N30/02G01N30/72G01N30/04G01N30/06G01N30/88G01N30/86
CPCG01N30/02G01N30/04G01N30/06G01N30/72G01N30/8634G01N30/88G01N2030/045G01N2030/8813G01N2570/00G01N2800/323
Inventor 崔松李克峰
Owner BEIJING ANZHEN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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