Anticancer combination of medication

An anti-cancer drug and composition technology, applied in the directions of drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problem of difficulty in forming effective drug concentrations, and achieve the effect of strengthening the anti-cancer effect

Inactive Publication Date: 2005-08-31
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, further studies have found that the excessive expansive hyperplasia of solid tumors has higher interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity than the surrounding normal tissue. Drug concentration (see KongQingzhong et al. "Intratumoral placement of cisplatin plus systemic carmustine to treat brain tumors in rats" "Journal of Surgical Oncology" 69 pages 76-82 (1998) (KongQ et al., J Surg Oncol.1998 Oct;69(2):76-82), simply increasing the dosage is limited by systemic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Put 90mg of PLGA with a molecular weight of 10000 (copolymer of glycolic acid and glycolic acid, the weight ratio of glycolic acid to glycolic acid is 25:75) into a container, add 100ml of dichloromethane, dissolve and mix well, then add 10mg of Nocoda azoles, shake again and dry in vacuo to remove organic solvents. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anticancer drug composition containing 10% by weight of nocodazole.

Embodiment 2

[0048] The method step of being processed into anticancer drug composition is identical with embodiment 1, and difference is that contained active ingredient is:

[0049] 0.01%-10% of cytochalasin, ellipticine chloride, ellipticine ellipticine, ellipticine methyl ellipticine, mitokloramine, mitoradone, mitokanihydrazone, mitonaphthine, Mitohydrazine, Mitoquinone, Mitospex, Mitotane, Mitonamamine, Mitozolid, Mitoransone, Colchicine, Salicylate, Colchicine, Colchicine, Norcolchicine, Thio-colchicine, Colcemid, Colchicamide, Colchicine, Norcolchicine, Thio-colchicine, Colchicine, Colchicamide, Colchicine, Cytochalasin, naphthyl carbamate, naphthol, α-naphthol, β-naphthol, α-naphthol phosphate, alcodazole, procodazole, giradazole, or malonic acid (salt ). The above are percentages by weight.

Embodiment 3

[0051] Put 80 mg of pharmaceutical excipient ethylene vinyl acetate copolymer (EVAc) into a container, add 100 ml of dichloromethane to dissolve and mix well, add 20 mg of β-naphthol, shake again, and then vacuum dry to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anticancer drug composition containing 20% ​​by weight of beta-naphthol. The drug release time of the anticancer drug composition in the physiological saline in vitro is 14-24 days, and the drug release time in the mouse subcutaneous is 20-35 days.

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PUM

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Abstract

An anticancer composition medicine is composed of the antimitosis medicine for suppressing the reproduction of tumor cells and the medicinal additive chosen from the biocompatible and biodegradable high-molecular polymer for slowly releasing said antimitosis medicine toward the tumor.

Description

(1) Technical field [0001] The invention relates to an anticancer drug composition, which belongs to the technical field of drugs. (2) Background technology [0002] The treatment of solid tumors mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutic drugs used, anti-mitotic drugs have obvious effects and have been widely used in various malignant tumors. However, further studies have found that the excessive expansive hyperplasia of solid tumors has higher interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity than the surrounding normal tissue. Drug concentration (see KongQingzhong et al. "Intratumoral placement of cisplatin plus systemic carmustine to treat brain tumors in rats" "Journal of Surgical Oncology" 69 pages 76-82 (1998) (KongQ et al., J Surg Oncol.1998 Oct; 69(2):76-82), simply increasing the dosage is limited by systemic reactions. (3) Contents of the invention [0003] The invention a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/08A61P35/00
Inventor 孔庆忠
Owner DASEN BIOLOGICAL PHARMA CO LTD
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