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Slow released anticancer combination of medication embedded the interior of the body

An anti-cancer drug and composition technology, which can be used in drug combination, drug delivery, anti-tumor drugs, etc., and can solve problems such as local formation of effective drug concentration in difficult tumors

Inactive Publication Date: 2007-02-14
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor (see Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of rat brain tumors" "Journal of Surgical Oncology" 69 pages 76-82 (1998) (Kong Q et al., J Surg Oncol.1998Oct; 69 (2 ):76-82), simply increasing the dosage is limited by systemic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Put 90 mg of polylactic acid (hole A) with a molecular weight of 10,000 in a container, add 100 ml of dichloromethane, dissolve and mix, add 10 mg of ifosfamide, shake again, and vacuum dry to remove the organic solvent. The dried solid composition is formed immediately, and then sterilized by radiation after being packaged to obtain an anticancer pharmaceutical composition containing 10% by weight of ifosfamide. The release time of the anticancer drug composition in physiological saline in vitro is 15-20 days, and the release time of the anticancer drug composition in subcutaneous mice is 30-40 days.

Embodiment 2

[0044] The method steps of being processed into the anticancer pharmaceutical composition are the same as those in Example 1, the difference is that the active ingredients contained are:

[0045] 5-30% by weight of three mustards, cyclophosphamide, sulfophosphamide, diphosphamide, horse phosphoramide, pephosphamide, trophosphamide, carbazole sulfamide, azomethine, amethanone, thymopentin, chlorine Mifen, Letrozole, Sodium Cantharidinium, Cantharidin, Sodium Cantharidin, Methyl Cantharidide, Hydroxycantharidin, Norcantharidin, Thiocolch, Racemic Phenylalanine Chlorine, Melasquin, Diantriazole, Mannosufan, Triosulfan, Ritrasuvan, Improsulfan, Mefenfenfoss, Spirobromopropamide, Mannitol Disulfonate, Triazinazolamide, Enprobamate, Epiperidine, butenolimine, ethidium bismorpholine, ethidoxyurea, ethidium, etoroglu, phosphoammonium, dipropoxyimine quinone, pipepobromane, piperosulfan, Pilitraxine, Bisantron, Bisantron, Rezosufang, Sodium Cyclohexyl Succinate, Rofecoxib, Aspicone, T...

Embodiment 3

[0047] Put 80 mg of polyglycolic acid and glycolic acid copolymer (PLGA) with a molecular weight of 10000 into a container, add 100 ml of dichloromethane, dissolve and mix, add 20 mg of letrozole, shake again, and then vacuum dry to remove the organic solvent . The dried solid composition is formed immediately, and then sterilized by radiation after being divided into packages to obtain an anticancer pharmaceutical composition containing 20% ​​by weight of letrozole. The drug release time of the anticancer drug composition in vitro in physiological saline is 15-20 days, and the drug release time in mice subcutaneously is 30-40 days.

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PUM

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Abstract

A slowly-releasing anticanser composite medicine implanted in human body is composed of the anticancer medicine prepared from implantation agent, slowly releasing agent and dichloroethane-kind medicine for suppressing the growth of tumor cells and the medicinal additive chosen from biocompatible and biodegradable polymer for slowly releasing said anticancer medicine toward tumor.

Description

(1) Technical field [0001] The invention relates to an anticancer drug composition implanted into the body and slowly released, belonging to the technical field of drugs. (2) Background technology [0002] The treatment of solid tumors mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutic drugs used, diclofenac has obvious effect and has been widely used in various malignant tumors. However, blood vessels, connective tissue, matrix proteins, fibrin and collagen in the tumor stroma not only provide scaffolds and essential nutrients for the growth of tumor cells, but also affect the chemotherapeutic drugs around the tumor and tumor tissue. intracellular penetration and diffusion (see Netti et al. "The effect of extracellular stroma conditions on drug delivery in solid tumors" Cancer Research 60 pp. 2497-503 (2000) (Netti PA, Cancer Res. 2000, 60 (9): 2497-503). Due to the excessive expansion and proliferation of solid tumors, the intersti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/08A61K9/00A61P35/00
Inventor 孔庆忠
Owner DASEN BIOLOGICAL PHARMA CO LTD
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