Antientity tumour medicinal composition containing topoenzyme inhibitor

A technology of topoase inhibitors and tumor drugs, which is applied in the field of anti-solid tumor drug compositions containing topoase inhibitors, and can solve the problems of difficult local formation of effective drug concentrations and limitations in tumors
CN1686552AInactive Publication Date: 2005-10-26DASEN BIOLOGICAL PHARMA CO LTD
8 Cites 29 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DASEN BIOLOGICAL PHARMA CO LTD
Publication Date
2005-10-26
Estimated Expiration
Not applicable · inactive patent
Patent Text Reader

Abstract

A composite medicine for treating tumor by locally putting it in the tumor is composed of the active anticancer components (topoenzyme inhibitor and its symergist chosen from taxol-type anticancer medicnie, antineoplastic antibiotic and antimetabolitic medicine) and the medicinal auxiliary (biocompatible and biodegradable high-molecular polymer).
Need to check novelty before this filing date? Find Prior Art

Description

(1) Technical field

[0001] The invention relates to an anti-solid tumor pharmaceutical composition containing a topozyme inhibitor, which belongs to the technical field of medicines. (2) Background technology

[0002] Cancer treatment mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutic drugs used, topoase inhibitors are more effective and have been widely used in various malignant tumors. Since topoase inhibitors exert their anti-tumor effect by inhibiting RNA synthesis, and the DNA repair function in many tumor cells is significantly increased after treatment, so effectively reducing or inhibiting the DNA repair function in tumor cells has become the current research topic. focus.

[0003] It has recently been found that inactivating or inhibiting intracellular DNA repair proteins can enhance the sensitivity of some tumor cells to chemotherapy, see Dolan et al. ""Cancer Research" 51 pp. 3367-3372 (1991) (Dolan et al., Cancer Res., 5...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More