NGF monoshell-multinuclear microsphere/PCL nanofiber catheter and preparation method thereof

A nanofiber and microsphere technology, applied in the field of biomimetic material preparation, can solve the problems of unsatisfactory long-segment nerve defect repair, lack of microstructure and chemical nutritional function, etc., to speed up nerve regeneration and promote nerve motor function Restoration and time-shortening effects

Inactive Publication Date: 2019-02-22
XIAN HONGHUI HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these scaffolds have a satisfactory repair effect on short-segment nerve defects, the repair effect on long-segment nerve defects is not ideal
After analyzing the reasons, we believe that the current neural tissue engineering scaffolds lack effective microstructure and chemical nutrition functions

Method used

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  • NGF monoshell-multinuclear microsphere/PCL nanofiber catheter and preparation method thereof
  • NGF monoshell-multinuclear microsphere/PCL nanofiber catheter and preparation method thereof
  • NGF monoshell-multinuclear microsphere/PCL nanofiber catheter and preparation method thereof

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Embodiment Construction

[0062] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0063] NGF single shell-multinuclear microsphere / PCL nanofiber catheter of the present invention has a structure such as figure 1 As shown, the polyacetate lactone PCL nanofiber nerve hollow conduit is included, and the inside of the polyacetate lactone PCL nanofiber nerve hollow conduit is uniformly filled with NGF-embedded single-shell-multinuclear microspheres, wherein the polyacetate lactone PCL The inner diameter of the nanofiber nerve hollow conduit is 0.7 mm, and the tube thickness of the polyacetate lactone PCL nanofiber nerve hollow conduit is 0.6 mm.

[0064] The preparation method of NGF single-shell-multinuclear microsphere / PCL nanofiber catheter is specifically implemented according to the following steps:

[0065] Step 1. Prepare NGF-embedded PLGA microspheres:

[0066]Step 1.1. Fully mix 50-100 μg NGF, 2-4 mg heparin and 50-1...

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Abstract

The invention discloses a NGF monoshell-multinuclear microsphere/PCL nanofiber catheter which can promote regeneration of peripheral nerves, govern functional reconstruction of target muscles and better promote recovery of motor function of peripheral nerves more quickly. The invention also discloses a preparation method of the NGF monoshell-multinuclear microsphere/PCL nanofiber catheter. The preparation method comprises the following steps: first, preparing NGF buried PLGA microspheres; then preparing NFG-buried monoshell-multinuclear microsphere and a polycaproloactone PCL nano fiber nervehollow catheter; and finally, dissolving the prepared NFG-buried monoshell-multinuclear microspheres in a PBS solution and injecting the solution into the polycaproloactone PCL nano fiber nerve hollowcatheter to obtain the NGF monoshell-multinuclear microsphere/PCL nanofiber catheter.

Description

technical field [0001] The invention belongs to the technical field of preparation methods of biomimetic materials, and in particular relates to an NGF single-shell-multi-core microsphere / PCL nanofiber catheter. The invention also relates to a preparation method of the NGF single-shell-multi-core microsphere / PCL nanofiber catheter. Background technique [0002] Peripheral nerve injury (PNI) has a high incidence in war trauma and is the most difficult type of injury in clinical treatment. After peripheral nerve injury, the nerve regeneration ability is limited, which often leads to sensory function, motor function and autonomic dysfunction in patients, and even causes permanent loss of physiological functions of target organs innervated by damaged nerves, causing patients to suffer lifelong disabilities and seriously affecting life. Quality has brought heavy psychological pressure and huge economic burden to families and society. Nerve damage is classified into the following...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/48A61L27/50A61L27/54
CPCA61L27/48A61L27/50A61L27/54A61L2300/252A61L2300/602A61L2400/12A61L2430/32C08L67/04C08L89/00
Inventor 曾文郝定均贺宝荣
Owner XIAN HONGHUI HOSPITAL
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