In-situ osteoplastic active calcium phosphate cement and its prepn and application

Abstract

The present invention discloses an in-situ osteoplastic active calcium phosphate cement and its preparation process and application. Sodium alginate, collagen, hydrocellulose, polypeptide molecular beam, etc. are used to embed BMP, FGF, TGF-beta and other composite to maintain the activity of bioactive factor. Embedded bioactive factor is made to compound with CPC powder and mix with curing liquid to form paste capable of being moulded at will and self hardened in human body environment and humidity. Inside body, the bioactive factor can induce formation of blood vessel and new bone, formation of active tissue and functional reconstruction. The used CPC cured body may be used as calcium source and phosphorus source for forming new bone and speeding bone tissue formation. The present invention is applied for filling and repairing of bone.

Description

technical field

[0001] The invention belongs to the field of medical materials, and relates to a calcium phosphate active bone cement hard tissue repair material which can be solidified in situ and can induce new bone formation. Background technique

[0002] Delayed fracture union, bone nonunion, and repair of bone defects are major unresolved problems in the field of orthopedics for a long time. Bone transplantation is the main means and method for the treatment of bone defects, including autologous bone transplantation, allogeneic bone transplantation, organic polymeric bone cement and bioceramics. Wait. The effect of autologous bone grafting is certain, but its source is limited. This way of digging flesh to fill the sore and treating trauma with trauma will cause the patient to suffer the pain of the second operation and complications in the bone donor site; allogeneic bone grafting is another option (Including allogeneic, that is, human bones and heterogeneous, that is...