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Preparation and application of fabric and its textile containing heparin and bioactive molecules

A bioactive molecule, heparin technology, applied in fiber treatment, spinning solution preparation, textile and paper making, etc., to achieve good biological safety, simple equipment and technology, and good shape

Inactive Publication Date: 2008-02-27
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the electrospinning preparation and application of fibers containing heparin and bioactive molecules and their fabrics have not been reported yet.

Method used

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  • Preparation and application of fabric and its textile containing heparin and bioactive molecules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) preparation gelatin concentration is 0.06 gram / ml, and heparin concentration is the mixed solution of 0.02 gram / ml, and solvent used is the trifluoroethanol / water compound solvent that volume ratio is 9: 11;

[0034] (2) Put the above solution into a syringe, and perform electrospinning under the action of a propulsion pump and a high-voltage generator to obtain heparin-containing gelatin fibers.

Embodiment 2

[0036] (1) the concentration of preparation P (LLA-CL) is 0.06 g / ml, and the mixed solution of heparin concentration is 0.0006 g / ml, and the solvent used is tetrahydrofuran / water composite solvent with a volume ratio of 10:1;

[0037] (2) Put the above solution into a syringe, and perform electrospinning under the action of a propulsion pump and a high-voltage generator to obtain heparin-containing P(LLA-CL) fibers.

Embodiment 3

[0039] (1) preparing a solution with a heparin concentration of 0.02 g / ml, the solvent used is water or a trifluoroethanol / water composite solvent with a volume ratio of 9:11;

[0040] (2) Prepare a solution with a P(LLA-CL) concentration of 0.06 g / ml, using trifluoroethanol, hexafluoroisopropanol or acetone solvent.

[0041] (3) Put the heparin solution into the supply syringe of the inner layer, put the P(LLA-CL) solution into the supply syringe of the outer layer, and adjust the supply rate of the inner and outer layers to 0.3 ml / hour and 0.9 ml / hour. Electrospinning is carried out under the action of a propulsion pump and a high-voltage generator to obtain heparin-containing fibers with a shell-core structure.

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Abstract

The present invention relates to a preparation of fiber and its fabric containing heparin and bioactive molecule and its application. Its preparation method includes the following steps: dissolving heparin or heparin and bioactive molecule composite and polymer together, electrostatic spinning to prepare nano / micron fiber or coaxial cospinning to prepare shell-core fiber. The obtained fiber has good modality, and can be easily made into film-like fabric or tubular fabric.

Description

technical field [0001] The invention belongs to the field of electrostatic spinning preparation and application of fibers and fabrics thereof, in particular to the preparation method and application of electrostatic spinning fibers and fabrics containing heparin or a compound of heparin and bioactive molecules. Background technique [0002] Heparin is an acidic mucopolysaccharide containing sulfate groups. Its molecule has a linear chain structure composed of six- or eight-saccharide repeating units. It is widely distributed in the liver, lung, heart, spleen, kidney, thymus, and intestine of mammals. Mucous membranes, muscles and blood. It has been found clinically that heparin has anticoagulant, antithrombotic, inhibits proliferation of glomerular mesangial cells, anti-tumor, anti-inflammation, prevents obstructive liver injury, prevents adhesions after abdominal surgery, and prevents heart, liver, and kidney from atherosclerosis. protection etc. At present, the clinical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F8/14D01D1/02D01D5/00D01D5/34A61L27/20
Inventor 莫秀梅陈峰何创龙王红声
Owner DONGHUA UNIV
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