Autologous whole blood homogenate compound for reconstruction of autologous skin epidermis protective screen

A technology of epidermis and compound, which is applied in the field of autologous whole blood homogenate compound and its preparation, can solve the problem of difficulty in providing microenvironment and cell growth factor concentration or content and type, difficulty in achieving biological effects, and skin barrier dysfunction and other problems, to achieve the effect of prevention and skin diseases, good skin repair and ideal effect

Inactive Publication Date: 2011-09-21
董萍 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] 3. When the epidermal barrier function is lost, a lot of water is lost
[0014] 4. Skin barrier dysfunction, increased intercellular space, and damaged skin integrity
But, because the serum (plasma) product of too low or too high concentration is not optimal concentration to the growth of cell, so be difficult to reach optimal biological effect; Moreover, too high blood concentration may suppress the proliferation of epidermal cell sometimes, Differentiation, even causing cytotoxicity, leading to epidermal cell damage (growth retardation or inhibition), it should be pointed out that serum (plasma) is only a part of whole blood, and usually can only provide the most basic nutrients and part of the microenvironment for epidermal cell growth conditions, it is difficult to provide the optimal microenvironment and the concentration or content and type of cell growth factors required for the autologous epidermis structure and its barrier reconstruction

Method used

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  • Autologous whole blood homogenate compound for reconstruction of autologous skin epidermis protective screen
  • Autologous whole blood homogenate compound for reconstruction of autologous skin epidermis protective screen
  • Autologous whole blood homogenate compound for reconstruction of autologous skin epidermis protective screen

Examples

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Embodiment 1

[0069] Example 1: A preparation method of an autologous whole blood homogenate compound for autologous skin epidermal barrier reconstruction

[0070] An autologous whole blood homogenate compound for autologous skin epidermal barrier reconstruction is composed of the following raw materials with optimal weight ratio:

[0071]

[0072] A specific preparation method of an autologous whole blood homogenate compound for autologous skin epidermal barrier reconstruction (take the preparation of 100ml as an example):

[0073](1) According to the raw material ratio of the blood homogenate compound used for epidermis reconstruction, accurately weigh 2.73 g of trisodium citrate, 0.22 g of sodium dihydrogen phosphate, and 3.2 g of glucose with an analytical balance. , 0.327g of citric acid, and 0.028g of adenine are placed in a decontaminated container, and the amount of normal saline is added to fully dissolve, mixed evenly, filtered and sterilized for use;

[0074] (2) Add the abov...

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Abstract

The invention discloses an autologous whole blood homogenate compound for reconstruction of an autologous skin epidermis protective screen. After the autologous whole blood is homogenized, under the synergetic effects of multiple bioactive substances and cell growth factors released by the autologous whole blood, the autoblood is effectively applied to epidermis repair and reconstruction of the skin protective screen, thereby giving better play to the maximum value and biological effects of the autoblood in autologous application; and because the autologous whole blood homogenate liquid plays a mutually cooperative protective effect with other auxiliary components and strengthens the compounding effect of the cell factors in epidermis reconstruction, the autologous whole blood homogenate liquid compound has good effects on epidermis repair and functional reconstruction of the epidermis protective screen, can improve the functional problems of the human skin protective screen in multiple aspects at different levels, restores the health of skin, and basically solves the functional problems of the epidermis protective screen. In addition, the preparation method disclosed by the invention is simple, convenient to operate, easy to learn and popularize, and suitable for medical cosmetology institutions with legal qualification for medical cosmetology.

Description

technical field [0001] The invention belongs to the field of beauty care and medical biotechnology, and relates to an autologous whole blood homogenate compound for autologous skin epidermis barrier reconstruction and a preparation method thereof. Background technique [0002] Technical background about human epidermis: [0003] The epidermis is the first protective barrier of the human body, and its main constituent cells are keratinocytes. In order to complete its barrier function, keratinocytes must undergo a complex and tightly regulated differentiation process, and finally form a layer including the basal layer, spinous layer, and granular layer. , layered structure of transparent layer and stratum corneum. [0004] 1. Basal layer: It is the bottom layer of the epidermis, connected with the deep dermis by the basement membrane. Basal layer cells are all attached to the basement membrane. It is the only cell in the epidermis that can divide and replicate, and can direc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61K8/64A61K35/14A61K38/18A61Q19/00A61P17/00
Inventor 杨永鹏董萍丁克祥左夏林罗迎霞丁宇
Owner 董萍
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