Multimodal brain function reconstruction assessment method based on magnetoencephalogram and diffusion tensor imaging

Abstract

The invention discloses a multimodal brain function reconstruction assessment method based on magnetoencephalogram and diffusion tensor imaging. The multimodal brain function reconstruction assessment method based on magnetoencephalogram and diffusion tensor imaging comprises the following steps: 1) selecting brain regions of interest from a subject, extracting magnetoencephalogram signals of corresponding brain regions, performing sliding time window splitting processing to extracted time series signals of each brain region, and calculating a function connection matrix existing in the subject; 2) according to the selected brain regions of interest, extracting diffusion tensor imaging data and calculating a structure connection matrix existing in the subject; 3) calculating the function-structure coupling value set of the subject; 4) performing calculation of functional state transition time periods to obtain a time period with the highest final function connection ascending velocity; 5) extracting a function-structure coupling value of time corresponding to the time period obtained in step 4) according to function-structure coupling values obtained in step 3). The method disclosed by the invention avoids errors caused by subjective factors; in combination with brain structure and function information, the limitation of making a judgment purely from the angle of function is avoided.

Description

technical field [0001] The invention relates to a multimodal signal analysis technology based on magnetoencephalogram and diffusion tensor imaging data, which belongs to the fields of image processing and signal processing. Background technique [0002] At present, after a period of treatment for depression patients, the clinical diagnosis of functional recovery is based on the relief of symptoms by clinicians, combined with scales such as the Hamilton Depression Rating Scale (HAMD) and the General Assessment Scale (GAS), through physician assessment and self-assessed by patients. This method is highly subjective and has extremely high requirements for the clinician's inquiry experience. In addition, the manifestation of symptoms often lags behind the changes in brain circuits. These factors will make it difficult to objectively and timely reflect the true degree of recovery of patients. [0003] After acute treatment, the level of functional activity of depression patien...

AI Technical Summary

Problems solved by technology

These factors will make it difficult to objectively and timely reflect the true degree of recovery of patients

[0003] After acute treatment, the level of functional activity of depression patients can be restored to a certain extent, but recurrent episodes may occur, that is, the function has not been truly restored

Images