Application of polypyrimidine sequence binding protein in preparation of drugs for repairing spinal cord injury

A technology combining proteins and polypyrimidines, applied in the field of biomedicine, can solve the problems of difficult tissue repair and functional reconstruction of SCI, limited neuron regeneration ability, and insufficient replenishment of neurons, and achieve good spinal cord injury repair and functional reconstruction. effect of effect
CN113171369APending Publication Date: 2021-07-27NANTONG UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
NANTONG UNIVERSITY
Publication Date
2021-07-27

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Abstract

The invention discloses an application of a polypyrimidine sequence binding protein silencing agent combined with retinoic acid and purinine amine in preparation of a medicine for repairing spinal cord injury, and belongs to the technical field of biological medicine. The polypyrimidine sequence binding protein (PTB) is silenced in vitro through a virus, and meanwhile, micromolecule retinoic acid (RA) and purinol amine (PMA) which are related to motor neuron differentiation are jointly added, so that mouse spinal cord reactive astrocytes are successfully reprogrammed into motor neuron; and help is provided for further in-vivo research on the effect of a PTB combined micromolecule reprogramming strategy in spinal cord injury post-repair, so that better spinal cord injury repair and function reconstruction effects are realized.
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Description

technical field

[0001] The invention belongs to the technical field of biomedicine, and specifically relates to the application of a polypyrimidine sequence-binding protein silencing agent in combination with retinoic acid and purmorphamine in the preparation of spinal cord injury repairing medicine. Background technique

[0002] Spinal cord injury (SCI) is a central nervous system injury disease with high disability rate and serious consequences, which seriously impairs the motor function of patients and often leads to paralysis below the injury site. Currently recognized SCI treatment has three major difficulties: First, rapidly activated reactive glial cells, especially astrocytes, will proliferate in large numbers to form dense glial scar tissue, allowing relatively slow-growing axons to extend through the injury When in the process of living, it encounters an insurmountable mechanical barrier and a chemical barrier formed by the secreted inhibitory factors; second, some...

Claims

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