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Umbilical cord mesenchymal stem cell external gel for promoting trauma healing, administration method and application

A technology of mesenchymal stem cells and cells, applied in the field of umbilical cord mesenchymal stem cell gel for external use, can solve problems such as patent publications that have not yet been found, and achieve the effect of promoting wound healing, promoting damage repair, and prolonging the effective time of action

Pending Publication Date: 2021-12-28
优赛生命科学发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Through the search, no patent publications related to the patent application of the present invention have been found

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  • Umbilical cord mesenchymal stem cell external gel for promoting trauma healing, administration method and application
  • Umbilical cord mesenchymal stem cell external gel for promoting trauma healing, administration method and application
  • Umbilical cord mesenchymal stem cell external gel for promoting trauma healing, administration method and application

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Embodiment Construction

[0055] The embodiments of the present invention will be described in detail below. It should be noted that the embodiments are illustrative, not restrictive, and cannot limit the protection scope of the present invention.

[0056] The raw materials used in the present invention, unless otherwise specified, are conventional commercially available products; the methods used in the present invention, unless otherwise specified, are conventional methods in the art.

[0057] A gel for external use of umbilical cord mesenchymal stem cells for promoting wound healing, the preparation steps are as follows:

[0058] (1) The mesenchymal stem cells isolated in vitro were cultured in primary culture medium at 37°C and 5% CO 2 Culture, turn over after 3-4 hours to infiltrate the cells with the medium, and continue to culture P0 generation cells for 7-10 days;

[0059] (4) The cell fusion degree reaches 50%-70%, the mass concentration of 0.9% sodium chloride injection washes the cells once...

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Abstract

The invention discloses umbilical cord mesenchymal stem cell external gel for promoting trauma healing. The umbilical cord mesenchymal stem cell external gel is prepared by the following steps of carrying out subculture on resuscitated umbilical cord mesenchymal stem cells, and carrying out an enrichment and concentration method to obtain high-concentration umbilical cord mesenchymal stem cells with biological activity; and matching with sodium alginate gel joint preparation to obtain the umbilical cord mesenchymal stem cell gel with high stability and permeability. The gel provided by the invention promotes the growth of the cells at a wound by applying the gel to the local wound in vitro, meanwhile, avoids bacterial invasion, reduces the possibility of infection, and provides a microenvironment beneficial to tissue growth for the wound, thereby promoting trauma healing, shortening the treatment time and reducing the pain of the wounded. The umbilical cord mesenchymal stem cell external gel is simple in operation, the finished product is convenient to store, the treatment cost of the wounded is reduced, and the treatment effect is improved.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to a gel for external use of umbilical cord mesenchymal stem cells for promoting wound healing, a drug delivery method and application. Background technique [0002] Trauma is damage to normal skin or tissue caused by external injury factors such as surgery, external force, heat, electric current, chemical substances, low temperature, and internal factors such as local blood supply disturbance. It is often accompanied by the destruction of skin integrity and the loss of a certain amount of normal tissue and impairment of normal skin function. Trauma healing is a dynamic, complex and orderly process, including ① coagulation phase: the first hemostatic response of the body that begins immediately after trauma formation; ② inflammatory phase: tissue ischemia due to local vasoconstriction, causing the release of vasoactive substances , and the body’s defense response caused by the presence...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61K9/06A61K47/36C12N5/0775A61P17/02A61P29/00A61K31/734
CPCA61K35/28A61K31/734A61K47/36A61K9/06A61K9/0014C12N5/0668A61P17/02A61P29/00C12N2501/11C12N2509/00C12N2509/10A61K2300/00
Inventor 陈晓波方芳胡学鑫韩洪起韩颢冯春玲吴学涛
Owner 优赛生命科学发展有限公司
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