Bionic bone repair scaffold body with layered structure and preparation method

A layered structure and scaffold technology, applied in prostheses, tissue regeneration, bone implants, etc., can solve problems such as difficulty in ensuring the mechanical properties of scaffolds, damage to scaffold materials, and unsuitability for clinical applications, etc., to achieve flexible adjustment of three-dimensional Dimensions, effect of mechanical transmission, good structural stability

Inactive Publication Date: 2011-12-28
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In its nested ring structure, since there is no technical point between the independent ring structures to maintain the tightness of the structure, it is difficult to ensure that the scaffold can provide sufficient and effective mechanical properties for bone repair. And during use, it will not cause replacement failure due to the movement or even falling off of the ring structures
Therefore, this design flaw has fatal damage to the scaffold material used for bone or cartilage repair and is not suitable for clinical application

Method used

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  • Bionic bone repair scaffold body with layered structure and preparation method
  • Bionic bone repair scaffold body with layered structure and preparation method
  • Bionic bone repair scaffold body with layered structure and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Dissolve 2g of chitosan in 50mL of acetic acid solution with a concentration of 2 (v)%, and stir fully to completely dissolve and evenly disperse chitosan. Add 1g Tween-20 and 1g Tween-80 to the chitosan solution, stir continuously at 1000 rpm for 30 minutes, quickly pour the foam-rich film-forming solution into a glass plate, and spread it horizontally to form a film In flake form, freeze at -20°C and dry in vacuum. Soak with 1 (w)% NaOH solution to neutralize the residual acetic acid in the membrane, fully wash with distilled water and freeze-dry to obtain a porous chitosan membrane material 2 containing pores 3, such as figure 1 As shown, the thickness in the wet state is 0.40mm. The membrane material 2 is fully water-absorbed and swollen, cut into a suitable size, and tightly spirally wound, and the edge part 1 of the end wrapping is eroded with a small amount of 2 (v)% acetic acid solution to dissolve the surface, and glued to the spirally wound cylinder Body-sha...

Embodiment 2

[0047] Dissolve 2g of polycaprolactone in 50mL of dimethyl sulfoxide, add 50g of 40-60 mesh NaCl particles, stir well to make the salt particles evenly distributed, and make a viscous film-forming liquid. Pour the film-forming solution into a glass plate, spread it horizontally into a film, and dry it in vacuum at 50°C. Soak and wash with distilled water repeatedly to remove NaCl particles in the membrane to obtain a porous polycaprolactone membrane material 2 with a thickness of 0.21 mm in a wet state. The membrane is cut to a suitable size, tightly spirally wrapped, and the end edge part 1 is eroded with a small amount of dimethyl sulfoxide on the surface, and bonded to the spirally wrapped cylinder. After drying, thoroughly soak and rinse with distilled water to remove residual solvents. A polycaprolactone porous scaffold unit 4 with a helically wound cylindrical structure was obtained, the pores 3 interconnected with each other, the average pore diameter was 223.1 μm, and...

Embodiment 3

[0049] Under the catalysis of calcium chloride, dissolve 10g of polyamide 66 in 100mL of absolute ethanol solution at 70°C to 80°C, and stir well to make a viscous film-forming liquid. After cooling to room temperature, the film-forming solution was poured into a glass plate, spread horizontally into a film, and dried at 60°C with a thickness of 0.15 mm. Repeated soaking and washing with distilled water, and drying at 70° C. to obtain porous polyamide 66 membrane material 2 . The membrane is cut to a suitable size, tightly spirally wrapped, and the end edge part 1 is etched with a small amount of ethanol solution containing calcium chloride on the surface, and bonded to the spirally wrapped cylinder. After drying, thoroughly soak and rinse with distilled water to remove residual solvents. A polyamide 66 porous scaffold unit 4 with a helically wound cylindrical structure was obtained, the pores 3 interconnected with each other, the average pore diameter was 68.0 μm, and the po...

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Abstract

Disclosed are a bionic bone repairing scaffold of a layered structure and a manufacturing method thereof. The scaffold is formed by at least one scaffold unit (4). The scaffold unit (4) is of a cylinder structure with a helical section, the cylinder structure is formed by continuously rolling a laminar material (2) tightly from inside to outside, and the diameter of the cylinder structure is from 0.1 mm to 50 mm. The structure is similar to the Harvard system of the natural bone, has a highly bionic effect, can well implement mechanical transfer between a defect site and normal bone tissue, can maintain good structure stability even in a degradation process, and completes the repair and function reconstruction of the bone tissue. The three-dimensional size of the bone repairing scaffold can be adjusted flexibly by controlling the thickness and height of the laminar material (2), and the number of rolling layers, so as to satisfy different use requirements.

Description

technical field [0001] The invention relates to a bionic bone repair support body with a layered structure and a preparation method thereof, which can be used to replace and repair bone tissue defects in the field of biomedicine. Background technique [0002] Bone tissue defect is a common clinical disease, which can be caused by trauma, tumor, bone disease and abnormal bone growth. For a long time, the development of high-performance clinical medical materials to replace and repair bone tissue defects has been a key topic in biomaterial research. [0003] An ideal bone repair material should have biological properties similar to those of natural bone, including: (1) biocompatibility: no cytotoxicity and inflammatory response, and conducive to cell adhesion and proliferation; (2) biomechanical properties: have certain (3) Three-dimensional porous structure: the material should have a three-dimensional porous structure, and the pore size should allow cell adhesion and growt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28A61L27/40A61L27/54
CPCA61L2430/02A61L2400/06A61L27/52A61L27/50A61L27/54A61F2002/2839A61L2300/44A61L27/40A61F2/28A61L2430/38A61L27/26
Inventor 李玉宝左奕江虹张利李吉东邹琴
Owner SICHUAN UNIV
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