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Fibrous membrane for tissue repair and manufacturing method and application thereof

A tissue repair and fibrous membrane technology, which is applied in the field of tissue repair fibrous membranes and its manufacture and application, can solve the problems of unsatisfactory performance of fibrous membranes for repair, easy generation of foreign body sensation and pain, adhesion of foreign bodies and immune reactions, etc., to achieve Product standards are easy to implement, comfort is improved, and production time is shortened

Active Publication Date: 2014-05-21
MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1) Woven mesh is currently the most widely used product in fiber membranes for tissue repair, but this type of product has rough surface, hard texture, poor biocompatibility, easy to produce foreign body sensation and pain, and common complications such as erosion and infection ; and the immune rejection caused by this type of material is strong, and there are many sequelae of surgery; when it is in direct contact with internal organs and organs, it is easy to cause damage, which can cause serious adhesions, serious foreign bodies and immune reactions, requiring two It is taken out by the first operation, which brings pain to the patient and even endangers the life
[0005] 2) The electrospun membranes currently studied often have the disadvantage that cells are difficult to grow into or grow slowly into the interior
[0006] It can be seen that the performance of the fiber membrane for tissue repair formed by the existing weaving and electrospinning technology is not ideal.

Method used

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  • Fibrous membrane for tissue repair and manufacturing method and application thereof
  • Fibrous membrane for tissue repair and manufacturing method and application thereof
  • Fibrous membrane for tissue repair and manufacturing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] (1) Dissolve polycarbonate polyurethane (PCU) in a mixed solvent of N,N-dimethylformamide and tetrahydrofuran, so that the concentration of PCU in the solution is 12g / 100mL, N,N-dimethylformamide and The mixing ratio (volume ratio) of tetrahydrofuran is 1:1 to obtain a uniform fiber filament material solution.

[0106] Dissolve PLLA in a hexafluoroisopropanol (HFIP) solution so that the concentration of PLLA in the solution is 5g / 100mL to obtain a uniform fiber silk material solution.

[0107] (2) Put the above two uniform fiber filament material solutions into two electrospinning syringes respectively, and arrange the corresponding needles of the two materials evenly on the high-voltage power supply board, adjust the speed of the micro-injection pump to 6ml / hour, Adjust the voltage of the high-voltage generator to 22KV, and adjust the receiving distance of the receiving device to 20cm. Through the simultaneous electrostatic co-spinning of the two materials, two kinds o...

Embodiment 2

[0111] (1) Dissolve polyvinylidene fluoride (PVDF) in a mixed solvent of N,N-dimethylformamide / acetone with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 18g / 100mL; - Polylactic acid (PLLA) was dissolved in hexafluoroisopropanol (HFIP) solution, so that the concentration of PLLA in the solution was 5g / 100mL to obtain a uniform fiber silk material solution.

[0112] (2) Put the above two uniform fiber filament material solutions into two electrospinning syringes respectively, and the corresponding needles of the two materials are evenly arranged on the high-voltage power supply board, and adjust the speed of the micro-injection pump to 5ml / hour, Adjust the voltage of the high-voltage generator to 22KV, and adjust the receiving distance of the receiving device to 20cm. Through the simultaneous electrostatic co-spinning of the two materials, two kinds of fiber membranes with different solubility properties are prepared, and the fiber membranes are int...

Embodiment 3

[0116] (1) Dissolve PVDF material in N,N-dimethylformamide / acetone mixed solvent with a volume ratio of 4:6, so that the concentration of PVDF in the solution is 18g / 100mL; prepare a uniform fiber filament material solution.

[0117] (2) Put the filament material solution obtained in step (1) into the electrospinning syringe, adjust the speed of the micro-injection pump to 6ml / hour, adjust the voltage of the high-voltage generator to 30KV, and adjust the receiving distance of the receiving device to 20cm, carry out electrospinning to obtain fibers, and accept the fibers into a film-like structure, spin until the thickness of the film layer is about 0.5mm, and then close the electrospinning to obtain a fiber film.

[0118] The fiber membrane obtained here has an average fiber diameter of 2 μm, a membrane thickness of 0.5 mm, an average pore diameter of 190 μm, a tensile strength of 43 N / cm, and a bulkiness of 170 cm 3 / g, the softness is 930 millinewtons.

[0119] (3) Complete...

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Abstract

The invention discloses a fibrous membrane for tissue repair, a manufacturing method thereof, application thereof for the preparation of products for tissue repair, and a product for tissue repair which is made by the fibrous membrane for tissue repair. The fibrous membrane for tissue repair is formed by interweaving cellosilks with the diameter of 10 nanometers-100 micrometers, and is of a porous structure; the filling power is 200-2000 cm<3> / g. According to the fibrous membrane for tissue repair, the conglutination and the proliferation of cells are facilitated, the guide of the cell differentiation is facilitated, the rapid growth of fibrocytes is facilitated, the tight suture between the fibrous membrane and tissue is facilitated, the comfort of a patient is improved, and the occurrence of conditions of patch shrink, infection and conglutination with visceral organs and the like is reduced.

Description

technical field [0001] The present invention relates to a fibrous membrane for tissue repair, its manufacturing method and application, and a product for tissue repair. Background technique [0002] Tissue and organ repair is a worldwide medical problem. In modern surgical operations, it is often necessary to repair tissues and organs, such as hernia repair, female pelvic floor dysfunction repair, dura / spinal defect repair, nerve conduit defect repair, blood vessel repair, ligament repair, bone defect repair wait. Due to the special structure and function of human tissue, the ideal fibrous membrane for tissue repair should have the following properties: ① a certain strength, able to resist mechanical stress, and be able to withstand the pressure in the abdominal cavity before the healthy tissue is fully formed; ② easy for cells to Adhesion, crawling and growth to achieve tissue regeneration; ③Prevent bacteria from hiding and breeding, and avoid infection caused by the use ...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61F2/40A61F2/10A61F2/06A61F2/08A61F2/28A61L27/50A61L31/14
Inventor 郭泽跃徐弢袁玉宇
Owner MEDPRINSHENZHEN REGENERATIVEA MEDICAL TECH CO LTD
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