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A polysaccharide of Rubus oleifera is used to inhibit blood coagulation

A technology for blood coagulation and blood coagulation, which is applied in blood diseases, extracellular fluid diseases, drug combinations, etc., and can solve problems such as hemorrhage, susceptibility to diet, and narrow anticoagulation treatment window

Inactive Publication Date: 2018-02-09
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Warfarin, the most commonly used oral anticoagulant among traditional anticoagulant drugs, has been used clinically for many years, but it has many limitations, such as delayed onset of action, narrow anticoagulant treatment window, easily affected by diet, and frequent monitoring and dosage adjustment, interactions with multiple drugs, and side effects such as major bleeding, etc.

Method used

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  • A polysaccharide of Rubus oleifera is used to inhibit blood coagulation
  • A polysaccharide of Rubus oleifera is used to inhibit blood coagulation
  • A polysaccharide of Rubus oleifera is used to inhibit blood coagulation

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Embodiment

[0036] 1. Extraction of water-soluble polysaccharides, oxalate-soluble pectin-like polysaccharides and alkali-soluble polysaccharides from Rubus sweet leaf of Rubus genus Rosaceae

[0037] (1) After pulverizing the dried leaves of Rubus sweet leaf, extract with 80% ethanol at 70°C for 90min by volume fraction, suction filter, discard the filtrate, and extract the filter residue twice with deionized water at 60°C for 120min each time, after cooling Suction filtration, the filter residue is used for extraction in the next step (2), combine the two filtrates, distill and concentrate under reduced pressure at 55°C, add three times the volume of absolute ethanol to precipitate, and stand at 4°C overnight; collect the precipitate a by suction filtration, weigh, Precipitate a was alternately washed 3 times with acetone, ether, and ethanol, dissolved in deionized water, added trichloroacetic acid equivalent to 2.5% of the mass of precipitate a, and stood at 4°C for 120 minutes; centrif...

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Abstract

The invention provides a mixture of water-soluble polysaccharides, oxalate-soluble pectin polysaccharides and alkali-soluble polysaccharides extracted from Rubus sweet leaf of Rubus genus Rosaceae for inhibiting blood coagulation.

Description

technical field [0001] The invention belongs to a kind of extracting Rubus sweet leaf polysaccharide extract from Rubus sweet leaf Rubus of Rosaceae plant, the mixture of water-soluble polysaccharide, oxalate-soluble pectin polysaccharide and alkali-soluble polysaccharide extracted from Rubus sweet leaf. Rubus polysaccharides are used to inhibit blood coagulation and belong to medicinal purposes. Background technique [0002] Blood coagulation refers to the process of blood changing from a liquid state to an immobile gel state, and is an important part of physiological hemostasis. Blood coagulation is a complex process. The coagulation mechanism adopts a cascade mechanism to amplify the coagulation signal step by step, and strengthen the coagulation process through multiple positive feedback links. At the same time, in order to prevent the accidental formation of thrombus under normal circumstances, or the uncontrolled thrombus formation at the bleeding site, the body also ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715C08B37/00C08B37/06A61P7/02
Inventor 邹晓青文杰彭圣明冯小婕
Owner XIANGTAN UNIV
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