5 results about "BRAF Protein" patented technology

This invention provides compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which can be applied to a host in need, such as humans, to treat conditions mediated by mutant BRAF, such as cancer. These compounds effectively degrade class I, II, and III mutant BRAF proteins.

The present invention provides compounds or their pharmaceutically acceptable salts and their pharmaceutical compositions that can be administered to a host such as a human in need thereof for the treatment of a disorder, such as cancer, mediated by mutant BRAF. The compounds efficiently degrade Class I, II and III mutant BRAF proteins.

The invention discloses a polymer composition and application thereof in preparation of a medicine taking a Braf protein degradation agent as an active component. The polymer composition is prepared from the following raw materials: fucoidan, hydroxyethyl cellulose and polyvinyl alcohol, according to the high-molecular composition, fucoidan, hydroxyethyl cellulose and polyvinyl alcohol with different molecular weights are adopted, a cross-linked network structure is formed through the strong hydrogen-bond interaction among molecules, the good slow-release effect on the Braf protein degradation agent is achieved, and the stability of the Braf protein degradation agent can be effectively improved; in addition, the invention also provides a pharmaceutical composition, and the pharmaceutical composition has good inhibitory activity on SK-MEL-28 human melanoma cells, has a good degradation effect on Braf protein in the SK-MEL-28 human melanoma cells, and has a good potential treatment effect on solid tumors such as melanoma.

The invention discloses a protein function prediction method based on a graph neural network and a GO term hierarchical relationship and a related device. The method comprises the following steps: obtaining protein sequence data, protein PPI data corresponding to the protein sequence data and protein GO term data corresponding to the protein sequence data; performing feature extraction processing based on the protein sequence data and the protein PPI data to obtain a protein feature vector; performing term feature extraction processing based on protein GO term data corresponding to the protein sequence data to obtain a term feature vector corresponding to each piece of protein GO term data; and mapping the protein feature vector and the term feature vector corresponding to each piece of protein GO term data into the same semantic space, and performing protein function prediction processing in the semantic space. In the embodiment of the invention, better protein prediction performance is achieved, and compared with a traditional prediction method, the performance is greatly improved.

The invention relates to a protein degradation targeting chimera compound with degradation and / or inhibition activity on mutant BRAF, and also relates to a pharmaceutical composition containing the protein degradation targeting chimera compound, and a preparation method and application of the protein degradation targeting chimera compound.