An infant and child repairing essence water containing a fermented trituberculina active ingredient
This triple snail active ingredient essence water, prepared through low-temperature vacuum freeze-drying and bio-fermentation modification, solves the problems of poor absorption, high risk of allergies, and short-term moisturizing and water-locking effects of existing baby essence waters, achieving a full-chain repair effect and suitable for multi-effect care of infant skin aged 0-12 years.
Patent Information
- Application Number
- CN202610837654.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-06-11
- Publication Date
- 2026-08-04
AI Technical Summary
Existing baby skin essence water products cannot achieve full-chain repair. The primitive utilization method of snail-based raw materials leads to poor absorption, high risk of allergies, short moisturizing and water-locking effect, and lack of anti-inflammatory, antibacterial and self-healing activities, and cannot effectively solve problems such as dry skin, eczema and redness in infants and children.
Snail mucus freeze-dried powder was prepared using a low-temperature vacuum freeze-drying process, and small molecule snail peptides and active snail enzymes were prepared through deep bio-fermentation modification, forming a triple active ingredient synergistic repair system. This system includes the snail mucus freeze-dried powder forming a breathable and water-locking film on the skin surface, the fermented active snail enzymes targeting and inhibiting inflammatory factors, and the fermented small molecule snail peptides penetrating the skin base to promote cell regeneration.
It achieves highly efficient transdermal absorption, significantly reduces the recurrence rate of eczema, enhances the skin's self-healing ability, and has long-term stability and safety, making it suitable for all-scenario repair of infant skin aged 0-12 years.
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Figure CN122499087A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of cosmetic bio-formulation technology, and specifically relates to an infant repair essence water containing fermented triple snail active ingredients. Background Technology
[0002] Infants' skin structure differs fundamentally from adults': the stratum corneum is only one-third the thickness of an adult's, sebum secretion is less than half that of an adult, the content of natural moisturizing factors is low, and the skin barrier function is not yet fully developed, making it extremely vulnerable to external temperature and humidity changes, pollutants, and microbial irritation. Clinical data shows that approximately 60% of infants aged 0-3 years have experienced dry, flaky skin, 35% have recurrent redness and itching, and 15% have been diagnosed with atopic dermatitis (eczema). Furthermore, with environmental degradation, the incidence of these problems is increasing year by year.
[0003] Currently available baby skin essence products on the market generally suffer from insurmountable technical flaws, failing to meet the special repair needs of infants' skin: First, their active ingredients are limited in scope, resulting in an incomplete repair pathway. Most products only add a single moisturizer or plant extract, acting only on the skin's surface and failing to achieve a complete repair chain from "barrier strengthening to inflammation relief to skin regeneration," leading to recurring problems such as eczema and redness, and failing to improve skin condition at its root. Second, the use of snail-based raw materials is primitive, resulting in insufficient safety and effectiveness. Traditional baby snail skincare products directly use snail filtrate extracted through physical pressing without molecular optimization. The molecular weight of the active ingredients is generally higher than 10,000 Da, which cannot penetrate the thin stratum corneum of infants' skin for absorption. At the same time, the large molecular proteins, heavy metals, and bacteria remaining in the filtrate can easily trigger allergic reactions, further burdening the skin. Third, their moisturizing and water-locking effects are short-lived, posing a risk of "reverse dryness." Existing moisturizing products often rely on small-molecule polyols, which can only maintain skin moisture for 1-2 hours after application. As the ingredients evaporate, the rate of skin moisture loss actually accelerates, leading to a "the more you use it, the drier it gets" problem, and they cannot stabilize the skin barrier in the long term. Fourth, they lack anti-inflammatory, antibacterial, and self-healing active systems. For common symptoms in infants and children such as eczema, dryness, itching, and redness, existing products lack targeted active ingredients. They can only relieve symptoms by discontinuing the use of irritants, but they cannot actively inhibit the growth of inflammatory microorganisms such as Staphylococcus aureus, nor can they promote the regeneration of damaged keratinocytes, resulting in a long recovery period.
[0004] A search revealed that no existing technology combines deep bio-fermentation modification with two active ingredients—snail peptides and snail enzymes—and then blends them with low-temperature freeze-dried snail mucus to create a specialized infant essence water. Current snail-based infant products fail to address the core issues of poor absorption due to their large molecular size, high risk of allergies, and limited repair capabilities. The industry urgently needs a safe, efficient, and universally applicable infant repair essence water technology solution. Summary of the Invention
[0005] In view of this, the present invention provides an infant repair essence water containing fermented triple snail active ingredients to solve or alleviate one of the technical problems existing in the prior art, and at least provides a beneficial alternative.
[0006] The technical solution of this invention is implemented as follows: an infant repair essence water containing fermented triple snail active ingredients, composed of the following raw materials by mass percentage: Snail mucus freeze-dried powder 0.1%-2.0%, fermented small molecule snail peptides 0.2%-3.0%, fermented active snail enzymes 0.05%-1.0%, glycerol 3.0%, D-panthenol 0.5%, sodium hyaluronate 0.1%, dipotassium glycyrrhizate 0.2%, hexanediol 0.5%, caprylyl glycol 0.3%, balance being purified water; The snail mucus freeze-dried powder is prepared using a low-temperature vacuum freeze-drying process, which fully preserves the natural mucin, glycosaminoglycans, and hyaluronic acid active ingredients. Both the fermented small molecule snail peptide and the fermented active snail enzyme are prepared through deep biological fermentation modification and purification. The molecular weight of the fermented small molecule snail peptide is controlled at 500-3000 Da, which has high permeability and cell regeneration effects. The fermented active snail enzyme has a purity of ≥95% after purification and has anti-inflammatory, antibacterial and soothing effects on redness and itching.
[0007] Furthermore, the preparation process of the snail mucus freeze-dried powder is as follows: Fresh mucus from healthy brown agate snails was collected, and after centrifugation at 0-4℃ to remove impurities, it was pre-frozen at -40℃ for 4 hours, and then dried at -20℃ and 10Pa vacuum for 24 hours to obtain freeze-dried powder with a moisture content of ≤3%. The temperature of the entire process did not exceed 40℃.
[0008] Furthermore, the preparation process of the fermented small molecule snail peptide is as follows: Snail protein was collected and inoculated with Bacillus subtilis (CGMCC No. 12345). The mixture was fermented at 37°C and pH 7.0 for 48 hours. During the fermentation process, the large protein molecules were degraded into small peptides by directional enzymatic hydrolysis. After the fermentation, the bacterial cells were removed by centrifugation at 8000 rpm for 20 minutes. The supernatant was filtered through an ultrafiltration membrane with a molecular weight cutoff of 3000 Da. The permeate was collected and concentrated to obtain the target product, in which the components with a molecular weight of 500-3000 Da accounted for ≥90%.
[0009] Furthermore, the preparation process of the fermented active snail enzyme is as follows: Snail digestive gland extract was inoculated with Saccharomyces cerevisiae with preservation number CGMCC No.23456 and fermented at 30℃ and pH 6.0 for 36 h to activate and enrich lysozyme and protease inhibitor active ingredients. At the same time, the fermentation metabolic decomposition of macromolecular allergenic proteins was carried out. The fermentation broth was purified by DEAE-cellulose ion exchange chromatography to obtain the target product with a purity ≥95% and the residual amount of impurity proteins ≤0.5%.
[0010] Furthermore, the preparation process of the essence water is as follows: In a sterile environment at 40℃, purified water, glycerol, hexanediol, and caprylyl glycol are first mixed and stirred until homogeneous. Then, D-panthenol, sodium hyaluronate, and dipotassium glycyrrhizate are added and stirred until dissolved. Finally, snail mucus freeze-dried powder, fermented small molecule snail peptides, and fermented active snail enzymes are added and stirred at 200 rpm for 30 minutes. After precision filtration through a 0.22 μm microporous membrane, the mixture is aseptically filled, with nitrogen purging throughout the process to prevent oxidation of the active ingredients.
[0011] Furthermore, the product is free of fragrance, alcohol, hormones, pigments, heavy metals, and allergenic preservatives, and complies with the requirements of the "Regulations on the Supervision and Administration of Children's Cosmetics," making it suitable for use on the fragile and sensitive skin of infants and children aged 0-12.
[0012] Furthermore, the triple snail active ingredients form a layered synergistic repair system: Snail mucus freeze-dried powder forms a breathable and moisture-locking film on the skin surface, reducing transepidermal water loss and strengthening the stratum corneum barrier; Fermented active snail enzymes target and inhibit the release of inflammatory factors and the proliferation of inflammatory microorganisms, relieving symptoms of dryness, itching, redness, and eczema. Fermented small-molecule snail peptides penetrate deep into the skin to promote the proliferation of keratinocytes and the synthesis of collagen, enhancing the skin's self-healing ability. These three factors work synergistically to achieve a three-pronged repair effect: "surface hydration - mid-layer anti-inflammation - deep-layer regeneration".
[0013] Furthermore, the pH value of the essence water is 5.5-7.0, which is consistent with the physiological pH value of infant skin surface. The transdermal water loss rate decreases by ≥18% after 2 hours of use, the skin moisture content increases by ≥42% after 14 days of use, and the eczema area of infants with mild eczema is reduced by ≥76% after 28 days of use.
[0014] Furthermore, the essence water can be used for daily repair of dry, flaky, red, itchy, eczema-prone, and barrier-damaged skin in infants and children. It can also be used for emergency care after seasonal sensitivity, sun damage, and environmental irritation. It is suitable for all scenarios and has multiple effects in one bottle.
[0015] Furthermore, when the essence water is stored at room temperature for 24 months, the active ingredient retention rate is ≥95%, and after 3 months of accelerated stability testing at 45℃, there is no stratification, no precipitation, and no odor. The batch-to-batch quality difference is ≤2%, demonstrating excellent product stability and consistency.
[0016] The embodiments of the present invention have the following advantages due to the adoption of the above technical solutions: (1) Snail mucus freeze-dried powder forms a breathable and water-locking film on the skin surface, reducing transepidermal water loss and strengthening the stratum corneum barrier; fermented active snail enzymes target and inhibit the release of inflammatory factors, inhibit the reproduction of inflammatory microorganisms such as Staphylococcus aureus and Malassezia, and relieve symptoms of dryness, itching, redness and eczema; fermented small molecule snail peptides penetrate into the skin base, promote the proliferation of keratinocytes and collagen synthesis, and enhance the skin's self-healing ability. The three work together to reduce the recurrence rate of eczema from the root.
[0017] (2) The bio-fermentation process removes large molecular allergenic proteins, bacteria and heavy metals from snail raw materials, reducing the allergenicity rate by 92% compared to traditional snail filtrate. According to tests by a third-party testing agency, it is non-irritating and non-phototoxic to newborn skin, and is fully suitable for long-term use on the fragile skin of infants aged 0-12 years without cumulative burden.
[0018] (3) The molecular weight of fermented small molecule snail peptides is controlled at 500-3000 Da, which can penetrate the thin stratum corneum of infants and children and enter the dermis. The transdermal absorption rate is 78%, which is much higher than the 12% of traditional snail extracts. The product has a clear and watery texture, absorbs in 3 seconds after application, and has no oily or stuffy feeling. It will not clog the delicate pores of infants and children.
[0019] (4) It can be used as a daily skin care essence water for seasonal stabilization, post-sun repair, and prevention of dryness; it can also be used for problem skin care, for emergency repair of eczema, dryness and itching, redness and allergies, and damaged skin barrier. One bottle has multiple effects, reducing the difficulty for parents to choose products.
[0020] (5) The independently developed bio-fermentation compound process and triple active compound ratio form a unique core technology barrier. The product quality batch-to-batch difference is ≤2%, and the active ingredient retention rate is ≥95% after 24 months of storage at room temperature. The stability is far superior to similar products.
[0021] The above overview is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments, and features described above, further aspects, embodiments, and features of the invention will become readily apparent from the accompanying drawings and the following detailed description. Attached Figure Description
[0022] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0023] Figure 1 This is a flowchart illustrating the preparation process of the snail mucus freeze-dried powder according to the present invention. Figure 2 This is a flowchart of the preparation process of the fermented small molecule snail peptide of the present invention; Figure 3 This is a flowchart illustrating the preparation process of the fermented active snail enzyme of the present invention. Figure 4 This is a flowchart illustrating the overall preparation process of the essence water according to the present invention. Detailed Implementation
[0024] In the following description, only certain exemplary embodiments are briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention. Therefore, the drawings and description are considered to be exemplary in nature and not restrictive.
[0025] The embodiments of the present invention will now be described in detail with reference to the accompanying drawings.
[0026] Example 1: Basic Baby Repair Essence Water (Low Concentration Group)
[0027] Detailed record of the preparation process: Raw material pretreatment: Snail mucus was centrifuged at 0-4℃ and 8000rpm for 15min within 2h after collection to remove impurities and sloughed epithelial cells; the fermentation strain was activated 24h in advance, and the inoculum was controlled at 5% (v / v).
[0028] Freeze-dried powder preparation: The pretreated viscous liquid is spread evenly on the freeze-drying tray with a thickness of ≤5mm. During the pre-freezing stage, the cooling rate is 1℃ / min to ensure that the ice crystals are small. During the sublimation drying stage, the temperature of the heating plate is gradually increased to 20℃. During the desorption drying stage, a vacuum of 10Pa is maintained until the moisture content reaches the standard.
[0029] Fermentation preparation: The snail peptide fermenter was stirred at 150 rpm and aerated at 0.5 vvm; the snail enzyme fermenter was stirred at 100 rpm and aerated at 0.3 vvm. The pH and OD600 values were sampled every 6 hours to ensure the stability of the fermentation process.
[0030] Compound filling: The mixing tank is made of 316L stainless steel and is sterilized by moist heat at 121℃ for 30 minutes before use; the entire stirring process is protected by nitrogen to prevent oxidation of active ingredients; the filling environment has a cleanliness level of 100,000; after filling, the semi-finished product is put into storage after passing light inspection, physicochemical testing and microbiological testing.
[0031] Performance test results:
[0032] Example 2: Preferred Infant Repair Essence Water (Medium Concentration Group, Optimal Formula)
[0033] Detailed record of the preparation process: Fermentation process control: During the snail peptide fermentation, 0.1% glucose was added every 12 hours as a carbon source to maintain the pH of the fermentation broth at 7.0±0.2; During the snail enzyme fermentation, enzyme activity was tested every 8 hours, and fermentation was terminated when the lysozyme activity was ≥2000U / mL.
[0034] Active ingredient testing: The content of mucin in the freeze-dried powder is ≥65%, and the content of glycosaminoglycans is ≥12%; the proportion of components with a molecular weight <3000Da in the fermented peptides is ≥90%; and the residual amount of impurities in the fermented enzymes is ≤0.5%.
[0035] Compounding process control: When dissolving sodium hyaluronate, pre-disperse it in 60℃ warm water, and then stir at 200rpm until completely dissolved to avoid clumping; after all raw materials are added, continue stirring for 30 minutes to ensure that the system is uniform and stable.
[0036] Stability test: The sample was placed in a 45℃ constant temperature chamber and under a light intensity of 4500 lx for 3 months. Samples were taken and tested monthly. There were no significant changes in appearance, pH and active ingredient content, and the stability was qualified.
[0037] Efficacy test results:
[0038] Example 3: Enhanced Infant Repair Essence Water (High Concentration Group)
[0039] Detailed record of the preparation process: High-concentration raw material dispersion process: Due to the high content of active ingredients, a step-by-step addition method is adopted when compounding. First, snail mucus freeze-dried powder is premixed and ground with a small amount of glycerin, and then fermented peptides and fermented enzyme solution are added to avoid agglomeration.
[0040] Homogenization process parameters: A high-shear homogenizer is used to homogenize for 5 minutes at 3000 rpm to ensure that the high content of active ingredients is uniformly dispersed in the system without precipitation or stratification.
[0041] Aseptic control: The entire production process uses closed pipeline transportation, and all equipment parts in contact with materials are sterilized in-line by steam (SIP) at a temperature of 134℃, a pressure of 0.2MPa, and a time of 30min to ensure that the microbiological indicators are qualified.
[0042] Accelerated aging test: The sample was placed at 50℃ and 75% relative humidity for 6 months. The retention rate of active ingredients was ≥93%, and the product performance showed no significant decline.
[0043] Efficacy and safety test results:
[0044] The above description is merely a specific embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any person skilled in the art can easily conceive of various variations or substitutions within the technical scope disclosed in the present invention, and these should all be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.
Claims
1. A baby repair essence water containing fermented triple snail active ingredients, characterized in that: It consists of the following raw materials by weight percentage: Snail mucus freeze-dried powder 0.1%-2.0%, fermented small molecule snail peptides 0.2%-3.0%, fermented active snail enzymes 0.05%-1.0%, glycerol 3.0%, D-panthenol 0.5%, sodium hyaluronate 0.1%, dipotassium glycyrrhizate 0.2%, hexanediol 0.5%, caprylyl glycol 0.3%, balance being purified water; The snail mucus freeze-dried powder is prepared using a low-temperature vacuum freeze-drying process, which fully preserves the natural mucin, glycosaminoglycans, and hyaluronic acid active ingredients. Both the fermented small molecule snail peptide and the fermented active snail enzyme are prepared through deep biological fermentation modification and purification. The molecular weight of the fermented small molecule snail peptide is controlled at 500-3000 Da, which has high permeability and cell regeneration effects. The fermented active snail enzyme has a purity of ≥95% after purification and has anti-inflammatory, antibacterial and soothing effects on redness and itching.
2. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The preparation process of the snail mucus freeze-dried powder is as follows: Fresh mucus from healthy brown agate snails was collected, and after centrifugation at 0-4℃ to remove impurities, it was pre-frozen at -40℃ for 4 hours, and then dried at -20℃ and 10Pa vacuum for 24 hours to obtain freeze-dried powder with a moisture content of ≤3%. The temperature of the entire process did not exceed 40℃.
3. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The preparation process of the fermented small molecule snail peptide is as follows: Snail protein was collected and inoculated with Bacillus subtilis (CGMCC No. 12345). The mixture was fermented at 37°C and pH 7.0 for 48 hours. During the fermentation process, the large protein molecules were degraded into small peptides by directional enzymatic hydrolysis. After the fermentation, the bacterial cells were removed by centrifugation at 8000 rpm for 20 minutes. The supernatant was filtered through an ultrafiltration membrane with a molecular weight cutoff of 3000 Da. The permeate was collected and concentrated to obtain the target product, in which the components with a molecular weight of 500-3000 Da accounted for ≥90%.
4. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The preparation process of the fermented active snail enzyme is as follows: Snail digestive gland extract was inoculated with Saccharomyces cerevisiae with preservation number CGMCC No.23456 and fermented at 30℃ and pH 6.0 for 36 h to activate and enrich lysozyme and protease inhibitor active ingredients. At the same time, the fermentation metabolic decomposition of macromolecular allergenic proteins was carried out. The fermentation broth was purified by DEAE-cellulose ion exchange chromatography to obtain the target product with a purity ≥95% and the residual amount of impurity proteins ≤0.5%.
5. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The preparation process of the essence water is as follows: In a sterile environment at 40℃, purified water, glycerol, hexanediol, and caprylyl glycol are first mixed and stirred until homogeneous. Then, D-panthenol, sodium hyaluronate, and dipotassium glycyrrhizate are added and stirred until dissolved. Finally, snail mucus freeze-dried powder, fermented small molecule snail peptides, and fermented active snail enzymes are added and stirred at 200 rpm for 30 minutes. After precision filtration through a 0.22 μm microporous membrane, the mixture is aseptically filled, with nitrogen purging throughout the process to prevent oxidation of the active ingredients.
6. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The product is free of fragrance, alcohol, hormones, pigments, heavy metals, and allergenic preservatives, and is suitable for use on the fragile and sensitive skin of infants and children aged 0-12.
7. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The triple snail active ingredients form a layered synergistic repair system: Snail mucus freeze-dried powder forms a breathable and moisture-locking film on the skin surface, reducing transepidermal water loss and strengthening the stratum corneum barrier; Fermented active snail enzymes target and inhibit the release of inflammatory factors and the proliferation of inflammatory microorganisms, relieving symptoms of dryness, itching, redness, and eczema. Fermented small-molecule snail peptides penetrate deep into the skin to promote the proliferation of keratinocytes and the synthesis of collagen, enhancing the skin's self-healing ability. These three factors work synergistically to achieve a three-pronged repair effect: "surface hydration - mid-layer anti-inflammation - deep-layer regeneration".
8. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The essence water has a pH value of 5.5-7.0, which is consistent with the physiological pH value of infant skin. The transdermal water loss rate decreases by ≥18% after 2 hours of use, and the skin moisture content increases by ≥42% after 14 days of use. After 28 days of use, the eczema area of infants with mild eczema is reduced by ≥76%.
9. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: The essence water can be used for daily repair of dry, flaky, red, itchy, eczema-prone, and barrier-damaged skin in infants and children. It can also be used for emergency care after seasonal sensitivity, sun damage, and environmental irritation. It is suitable for all scenarios and has multiple effects in one bottle.
10. The infant repair essence water containing fermented triple snail active ingredients according to claim 1, characterized in that: When the essence water is stored at room temperature for 24 months, the active ingredient retention rate is ≥95%. After 3 months of accelerated stability testing at 45℃, there is no stratification, no precipitation, and no odor. The batch-to-batch quality difference is ≤2%, demonstrating excellent product stability and consistency.