Tumor treatment synergism combination drug

A drug and tumor technology, applied in the fields of medicine and biology, can solve the problems such as autophagy inhibitors and doxorubicin that have not yet been seen

Inactive Publication Date: 2014-01-15
FUDAN UNIV
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Problems solved by technology

[0011] So far, there have been no relevant reports on the preparation of drug complexes made of autophagy inhibitors and doxorubicin, especially synergistic drug compositions for the treatment of tumors

Method used

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  • Tumor treatment synergism combination drug
  • Tumor treatment synergism combination drug
  • Tumor treatment synergism combination drug

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Preparation of doxorubicin: Weigh 16 mg of doxorubicin and dissolve in 10 ml of sterile water. Stir well for 30 minutes and filter through a 0.1 μm sterile filter. Divide into 10 tubes for storage. Dilute 200-800 times in vitro.

[0044] Configure autophagy inhibitor drugs separately:

[0045] (1) Preparation of chloroquine: Dissolve an appropriate amount of chloroquine in pure water to form a storage solution of 10mmol / L, filter and sterilize with a 0.1 μm filter and store at 4°C, and dilute 500-1000 times in an in vitro laboratory to inhibit cell autogenesis. bite

[0046] (2) Preparation of ammonium chloride: Dissolve an appropriate amount of ammonium chloride in water to prepare a 0.4 mol / L storage solution, filter and sterilize with a 0.1 μm filter, and store at 4°C. Diluted 50-80 times in vitro to inhibit autophagy

[0047] (3) Preparation of hydroxychloroquine: Dissolve an appropriate amount of hydroxychloroquine in pure water to form a 10mmol / L stock soluti...

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Abstract

The present invention belongs to the technical field of medicine and biology, and relates to an antitumor drug synergism drug, particularly to a tumor treatment synergism drug composition comprising an autophagy inhibitor and adriamycin. The combination drug comprises one or a plurality of autophagy inhibitors and adriamycin, and is provided for treating tumors by adopting a combination administration or sequential use mode, wherein tumor cell autophagy induced by adriamycin can be inhibited to counteract antagonism effects of tumors on treatments of adriamycin due to autophagy so as to significantly enhance tumor treatment effects of adriamycin. The synergism drug composition is suitable for treatment of lymphoma, lung cancers, brain tumors, breast cancers and myeloma.

Description

technical field [0001] The invention relates to the fields of medicine and biotechnology, and relates to synergistic drugs for antitumor drugs, in particular to a synergistic drug composition for treating tumors composed of an autophagy inhibitor and adriamycin. Background technique [0002] Malignant lymphoma can be mainly divided into Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL), of which non-Hodgkin's lymphoma accounts for the vast majority. According to the World Health Organization's International Agency for Research on Cancer, the incidence of NHL has increased worldwide and is significantly higher in developed countries than in Africa and Asia. The etiology of malignant lymphoma is complex and has not been fully studied yet, and the long-term survival rate is low. Doxorubicin has been widely used as one of the main drugs in chemotherapy for malignant lymphoma. Studies have shown that doxorubicin induces apoptosis of tumor cells mainly by intercalating be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P35/00A61K31/704
Inventor 鞠佃文范佳君史训龙周珮曾贤李玉彬王子玉叶丽冯美卿李继扬朱海燕黄海
Owner FUDAN UNIV
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