Low crystal-water ceftriaxone crystals and preparation method thereof
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- XIANGBEI WELMAN PHARMA CO LTD
- Publication Date
- 2010-06-23
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention relates to the field of chemical synthesis, in particular to ceftriaxone sodium crystals with low crystal water and a preparation method thereof. Background technique
[0002] Ceftriaxone sodium (ceftriaxone sodium), also known as ceftriaxone, ceftriaxone, Junbizhi, cephalosporin, etc., chemical name: (6R, 7R)-7-[[(2-amino-4 -thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1 , 2,4-triazin-3-yl)thio]methyl]-5-thio-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt triple half Hydrate. Ceftriaxone sodium is a semi-synthetic long-acting, broad-spectrum third-generation cephalosporin with a mechanism of action similar to that of penicillin. It is white or off-white crystalline powder, odorless and tasteless, hygroscopic, easily soluble in water, slightly soluble in methanol, almost insoluble in chloroform or ether, and the aqueous solution is yellow to amber due to different concentrations. ...