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Antibacterial composite medicine

A technology of antibacterial drugs and compositions, applied in the field of medical application of antibacterial combined drugs, to achieve the effects of easy use, increased action and application range, and reduced side effects and drug resistance

Inactive Publication Date: 2003-09-17
GUANGZHOU PUIS PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] From the research that people carry out the combination of cephalosporins, but so far, there is no report that people carry out research on the combination of cephradine and ceftriaxone. Pine mixed into antibacterial combination drugs, the antibacterial combination drugs have strong activity against Gram-positive bacteria, but also have strong activity against Gram-negative bacteria, and have good curative effect on infections caused by most pathogenic bacteria. Compared with single use of cephradine or ceftriaxone, it is significantly improved, and has a synergistic effect, producing unexpected effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] prescription:

[0040] Ceftriaxone 5000g

[0041] Cephradine 5000g

[0042] Sodium Benzoate 10g process:

[0043] Get above-mentioned amount of ceftriaxone 5000g, cephradine 5000g, sodium benzoate 10g, in the powder injection workshop, under aseptic state, mix homogeneously, pack 10000 bottles of vials (every bottle contains cephradine 0.5g, ceftriaxone 0.5g), namely Obtain the compound powder injection of the present invention.

Embodiment 2

[0045] prescription:

[0046] Ceftriaxone 7500g

[0047] Cephradine 7500g

[0048] Sodium Salicylate 10g Process:

[0049] Get the above-mentioned amount of ceftriaxone 7500g, cephradine 7500g, sodium salicylate 10g, in the powder injection workshop, under aseptic condition, mix homogeneously, pack 10000 bottles of vials (every bottle contains cephradine 0.75g, ceftriaxone 0.75g) , to obtain the compound powder for injection of the present invention.

Embodiment 3

[0051] prescription:

[0052] Ceftriaxone 5000g

[0053] Cephradine 10000g

[0054] Niacinamide 10g process:

[0055] Take 5000g of ceftriaxone, 10000g of cephradine, and 10g of nicotinamide in the powder injection workshop, mix them evenly in a sterile state, and pack them into 10,000 vials (each bottle contains 1.0g of cephradine and 0.5g of ceftriaxone). The compound powder injection of the present invention.

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PUM

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Abstract

An antibacterial composite medicine is prepared from ceftriaxone and cefradine in the radio of 1:(0.1-10) and they have cooperation effect. Its medical application is also disclosed.

Description

Technical field: [0001] The invention relates to an antibacterial combination medicine, in particular to an antibacterial combination medicine composed of ceftriaxone and cefradine, and the medical application of the antibacterial combination medicine. Background technique: [0002] Ceftriaxone is a third-generation cephalosporin for injection. This product has strong activity against Enterobacteriaceae bacteria. MIC against Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii, Indole-positive Proteus, Prufidenia and Serratia 90 Between 0.12-0.25mg / L. This product has strong antibacterial effect on influenza bacillus, Neisseria gonorrhoeae and meningococcus, and also has good effect on hemolytic streptococcus and pneumococcus, and its MIC against Staphylococcus aureus is 2-4mg / L. It can be used to treat lower respiratory tract, urinary tract, and intestinal infections caused by sensitive bacteria such as Enterobacteriaceae, as well as abdom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04
Inventor 贝庆生
Owner GUANGZHOU PUIS PHARMA FACTORY
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