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Treatment method of cephalosporin synthesizing pharmaceutical production wastewater

A treatment method and waste water technology, which is applied in natural water body treatment, water/sewage multi-stage treatment, water/sludge/sewage treatment, etc., can solve the problems of low purity of distillation products and large energy consumption, and achieve high purity and solid Residue reduction and odor reduction effects

Active Publication Date: 2015-05-20
珠海保税区丽珠合成制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the required energy consumption is large, and the purity of the distillation product is low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Get 100 liters of the Qusone still residue just discharged in the reaction bottle / reaction tank, and the still residue contains ethanol, acetone, triethylamine, water. COD > 150000mg / L was tested. The amount of sewage is 10 tons / day. Add 30% sodium hydroxide dropwise with rapid stirring for 10-30 minutes, adjust pH=13.0-13.5, and control temperature T=10-50°C. Leave to stand for stratification for 30min-60min, the upper layer is about 6.9 liters of triethylamine and a small amount of suspended matter, calculated according to the amount of recovery=recovered triethylamine / the amount of triethylamine input during the production of ceftriaxone sodium, the recovery is about 0.73 %.

[0030] The upper organic phase was filtered to obtain high-purity triethylamine (by gas phase detection, the purity of triethylamine was >95%). The lower aqueous phase contains accelerators M-Na, acetone, and cephalosporin degradation products. The aqueous phase was extracted once with 30 l...

Embodiment 2

[0034] Get 100 liters of the Qusone still residue just discharged in the reaction bottle / reaction tank, and the still residue contains ethanol, acetone, triethylamine, water. COD > 150000mg / L was tested. The amount of sewage is 10 tons / day. Add 30% sodium hydroxide dropwise with rapid stirring for 10-30 minutes, adjust pH=11.5-12.0, and control temperature T=10-50°C. Leave to stand for 30min-60min to separate layers, and the upper layer is about 5.5 liters of triethylamine and a small amount of suspended matter.

[0035] The upper organic phase was filtered to obtain high-purity triethylamine (by gas phase detection, the purity of triethylamine was >95%). The lower aqueous phase contains accelerators M-Na, acetone, and cephalosporin degradation products. The aqueous phase was extracted once with 30 liters of dichloromethane, stirred for 10-15 minutes, and allowed to stand for 15-30 minutes. Dichloromethane, ethanol, and acetone are contained in the lower organic phase obta...

Embodiment 3

[0039] Get 100 liters of the Qusone still residue just discharged in the reaction bottle / reaction tank, and the still residue contains ethanol, acetone, triethylamine, water. COD > 150000mg / L was tested. The amount of sewage is 10 tons / day. Add 30% sodium hydroxide dropwise with rapid stirring for 10-30 minutes, adjust the pH to 12-12.5, and control the temperature to T=10-50°C. Let it stand for 30min-60min to separate layers, and the upper layer is about 6.0 liters of triethylamine and a small amount of suspended matter.

[0040]The upper organic phase was filtered to obtain high-purity triethylamine (by gas phase detection, the purity of triethylamine was >95%). The lower aqueous phase contains accelerators M-Na, acetone, and cephalosporin degradation products. The aqueous phase was extracted once with 30 liters of dichloromethane, stirred for 10-15 minutes, and allowed to stand for 15-30 minutes. Dichloromethane, ethanol, and acetone are contained in the lower organic p...

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PUM

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Abstract

The invention relates to a treatment method of ceftriaxone wastewater. The treatment method comprises the following steps: 1) adding a strong base to ceftriaxone kettle residue to regulate the pH to the range of 13.0-13.5, stirring, standing for layering, and separating the organic phase of the upper layer from the water phase of the lower layer; 2) adding dichloromethane to the organic phase, stirring, extracting the organic matter, and standing to separate out the organic phase; 3) adding strong acid to the water phase to regulate the pH to the range of 1.9 to 2.1, stirring and centrifugally separating out 2-mercaptobenzothiazole; and 4) adding activated carbon to the water phase, and introducing ozone under the irradiation of an ultraviolet lamp for oxidization for 60-90 minutes.

Description

technical field [0001] The invention relates to the field of wastewater treatment, in particular to a treatment device and method for cephalosporin wastewater. Background technique [0002] Ceftriaxone (also known as ceftriaxone) is a third-generation broad-spectrum, high-efficiency, long-acting, low-toxic injection cephalosporin, which is widely used in clinical practice. At present, the main synthetic route is to use 7-aminocephalosporanic acid (7-ACA) as raw material to react with thiotriazine to generate 7-aminocefatriazine (7-ACT), and then react with aminothioxime active thioester to generate Ceftriaxone. It is known from the production raw materials and process characteristics that this type of wastewater has complex components, high concentration of organic matter, contains refractory substances and inhibitory antibiotics, many of which are toxic, and nitrogen elements are likely to be nitrosated. If discharged into water bodies, it will be harmful to the environmen...

Claims

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Application Information

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IPC IPC(8): C02F9/08C02F103/36
Inventor 王建军王鉴哲朱振峰陈晓赟李波明建
Owner 珠海保税区丽珠合成制药有限公司
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