Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antibacterial medicinal composition

A technology of antibacterial drugs and compositions, applied in the field of pharmaceutical preparations, can solve problems such as large half-life differences, drug resistance, and difficulty in synergistic curative effects

Inactive Publication Date: 2005-10-12
HAIKOU QILI PHARMA
View PDF2 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term use also faces the problem of drug resistance, which affects the efficacy of drugs
Tazobactam is a commonly used β-lactamase inhibitor. Because its half-life is 1 hour, and ceftriaxone is 8 hours, it is generally believed that due to the large difference in the half-life of the two drugs, it is difficult to have a synergistic effect when used in combination (US6090801) , so now more research is the compound preparation of ceftriaxone and sulbactam (CN1404834A)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Ceftriaxone sodium and tazobactam sodium powder injection (3:1) and preparation method thereof:

[0047] Under the environment of aseptic cleanness and air relative humidity not greater than 55%, mix 894g of ceftriaxone sodium (equivalent to 750g of ceftriaxone) and 294g of tazobactam sodium (equivalent to 250g of tazobactam) aseptic powder Evenly, grind, pass through a No. 6 sieve, and pack into 1000 bottles.

Embodiment 2

[0049] Ceftriaxone sodium and tazobactam sodium powder injection (5:1) and preparation method thereof:

[0050] Under the environment of aseptic cleaning and air relative humidity not more than 55%, 893.9g of ceftriaxone sodium (equivalent to 750g of ceftriaxone) and 176.5g of tazobactam sodium (equivalent to 150g of tazobactam) were sterile The powder is mixed and ground, passed through a No. 6 sieve, and packed into 1000 bottles.

Embodiment 3

[0052] Freeze-dried preparation and preparation method thereof

[0053] Dissolve 894g of citriaxone sodium, 294g of tazobactam sodium, and 70g of mannitol in 1000ml of water for injection, let it dissolve, add activated carbon for injection, stir for 8 minutes, add water for injection to 2000ml, and remove carbon through a titanium sand core while it is hot Suction filter into a clean container, and the filtrate is sterilized and filtered through a 0.22um microporous membrane, filled (2ml per unit), and freeze-dried.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A composite antibacterial medicine with durable and high curative effect is proportionally prepared from ceftriaxone and tazobactam, or their soduim salts.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a compound preparation of antibacterial drugs. Background technique [0002] Cephalosporin antibiotics are widely used in clinical antibacterial drugs. Due to long-term and large-scale clinical use, bacteria are resistant to cephalosporin antibiotics, which greatly affects the efficacy of these drugs. The main mechanism of bacterial resistance to cephalosporin antibiotics is to produce specific β-lactamases, which can decompose drugs and reduce the efficacy of drugs. In order to overcome the defect of drug resistance, in recent years, there have been continuous reports on the combined use of cephalosporin antibiotics with β-lactamase inhibitors, that is, to maintain the maximum efficacy of drugs by inhibiting β-lactamase. The more commonly used β-lactamase inhibitors are sulbactam (SBT), tazobactam (TAZ) and clavulanic acid (clavulanic acid). [0003] Ceftriaxone is a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/43A61K31/549A61P31/04
Inventor 韩克胜
Owner HAIKOU QILI PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com