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Completely biodegradable polyester material and preparation and application of completely biodegradable polyester

A technology for biodegrading polyester and caprolactone, which is applied in the field of polymer biodegradable materials, can solve problems such as unsatisfactory product performance, achieve controllable degradation speed, excellent mechanical properties, and improve flexibility

Inactive Publication Date: 2014-12-24
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the deficiencies and current situation of biodegradable polymer materials in the prior art, the purpose of the present invention is to provide a fully biodegradable polyester material, which is used for artificial bone bodies, tissue engineering scaffolds, and interventional medical treatments in biomedicine. Apparatus and other fields to prepare corresponding products to overcome the shortcomings of unsatisfactory performance of products prepared from degraded polymers provided by the prior art

Method used

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  • Completely biodegradable polyester material and preparation and application of completely biodegradable polyester
  • Completely biodegradable polyester material and preparation and application of completely biodegradable polyester
  • Completely biodegradable polyester material and preparation and application of completely biodegradable polyester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Mix 0.05 parts of n-decyl alcohol initiator with 25 parts of purified cyclic lactone (the ratio of lactic acid monomer to caprolactone monomer is 90:10), vacuum dry, and then add 0.01 parts based on the mass of cyclic lactone % of catalyst mixed, filled with nitrogen to drive away oxygen, vacuumize, repeat three times, control the vacuum degree of 0.05mmHg, vacuum seal the tube and react at 130°C for 48 hours to obtain a degradable poly(L-lactic acid-caprolactone) copolymer . The resulting product was purified and the number average molecular weight was determined to be 8.1×10 4 g / mol.

[0029] Dissolve 6 parts / gram of poly-L-lactic acid in 20 mL of dichloromethane solvent, add 4 parts / gram of the above-prepared poly(L-lactic acid-caprolactone) copolymer, stir well to completely dissolve the polymer, and gradually Add dropwise to 100mL of 1:1 water / ethanol mixture to precipitate the blend, filter and dry to obtain a fully biodegradable polyester material with mechanic...

Embodiment 2

[0031] After drying 20 parts of poly(L-lactic acid-caprolactone) obtained in Example 1 and 180 parts of poly-L-lactic acid at 80°C for 5 hours, they were added to a twin-screw extruder, and the screw speed was controlled at 15 rpm , the extrusion temperature is 180°C, and the residence time of the material is 5 minutes, that is, a fully biodegradable polyester material with excellent mechanical properties is obtained.

Embodiment 3

[0033] Mix 0.1 part of tris(hydroxymethyl)ethane initiator with 50 parts of purified cyclic lactone (the ratio of lactic acid monomer to caprolactone monomer is 90:10), vacuum dry and follow the method described in Example 1 Synthesis of degradable poly(L-lactic acid-caprolactone) copolymers. The resulting product was purified and the number average molecular weight was determined to be 5.8×10 4 g / mol.

[0034] Dissolve 7.5 parts / gram of poly-L-lactic acid in 30 mL of dichloromethane solvent, add 2.5 parts / gram of poly(L-lactic acid-caprolactone) copolymer, stir well to dissolve the polymer completely, then gradually add to 200 mL The blend is precipitated in the water, filtered, and dried to obtain a fully biodegradable polyester material with excellent mechanical properties.

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Abstract

The invention discloses a completely biodegradable polyester material and preparation and application of the completely biodegradable polyester. The material comprises the following components: 60-98 percent of poly(L-lactic acid) and 2-40 percent of poly(L-lactic acid-caprolactone) copolymer, wherein the molecular weight of the copolymer is 10000-100000, a number ratio of lactic acid units to caprolactone units is (95:5) to (20:80), and the copolymer contains arms of 1-6 specific structures. The preparation method of the material comprises the following steps: dissolving poly(L-lactic acid) into an organic solvent in which polylactic acid can be dissolved, adding the copolymer in a formula amount, and fully stirring, so that the copolymer is completely dissolved; and adding a polymer solution into water or a mixed solution of water / alcohol, separating out the blend by precipitating, filtering, and drying, thereby preparing the to-be-prepared completely biodegradable polyester material. The material can be used for preparing corresponding products in the fields of artificial bones, scaffolds for tissue engineering and interventional medical equipment in biomedicine, and the prepared product has excellent mechanical property and biodegradability.

Description

technical field [0001] The invention relates to the technical field of polymer biodegradable materials, and more specifically relates to a fully biodegradable polymer material and its preparation method and application. Background technique [0002] Biodegradable polymer materials are a kind of polymer materials that can be degraded in the body after performing corresponding functions in the human body and are gradually absorbed or excreted. They will not remain permanently in the body as foreign objects and affect human physiology and life. With the development of modern medicine, more and more biodegradable polymer materials are used in many products that do not need to be stored in the body for a long time. [0003] Degradable polymer material-polylactic acid is a commonly used degradable polymer material in biomedicine, and its molecular weight and crystallinity greatly affect its mechanical properties. Polylactic acid has adjustable strength, but its brittleness often ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08G63/08B29C47/92B29C48/92
Inventor 罗祥林陈元维李成龙
Owner SICHUAN UNIV
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