Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medical composite material and preparing method thereof

A technology of composite materials and matrix materials, which is applied in the field of medical composite materials and their preparation, can solve the problems of not meeting the strength requirements of medical devices, lack of strength retention time, and reduced strength of composite materials, and achieve simple and easy synthesis and preparation methods and Processing technology, solve the difficulty of preparation and processing, and meet the effect of high strength

Active Publication Date: 2016-11-23
上海发微医用材料有限公司
View PDF10 Cites 23 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, due to the instability of the mechanical properties of the linear polymer material, the material degrades rapidly, or due to the hydrolysis of the fibers, the strength of the composite material decreases rapidly in a short period of time, and does not have sufficient strength retention time.
[0007] It can be seen that fiber-reinforced linear degradable polymers still cannot meet the strength requirements of some medical devices
This poses a great challenge to the base material of composite materials, which must not only have high initial strength, but also maintain a long strength retention time during the material degradation process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The preparation method of medical composite material provided by the invention comprises:

[0037] (1) Synthesis of monomers, initiators and catalysts into biodegradable polymer prepolymers with two or more arms

[0038] The monomers mentioned therein include, but are not limited to, glycolide, L-lactide, mixed-lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, glycolic acid, salicylic acid Acids, carbonates, amino acids and their derivatives. In some embodiments, the copolymer is composed of two monomers, for example, the monomers are glycolide and L-lactide, and the monomers are mixed-lactide and glycolide. There is no particular requirement on the ratio between the monomers for preparing the copolymer. In some embodiments, the copolymer consists of two monomers in a weight ratio of 1:1 to 50:1, preferably 20:1.

[0039] Different initiators (2 arms, 3 arms, 4 arms) were selected to control the number of arms of the degradable polymer prepolymer. Wherei...

Embodiment 1

[0072] Example 1: Degradable glass fiber reinforced cross-linked PLGA composite material

[0073] Synthesis of degradable polymer prepolymers:

[0074] Before the polymerization, the reactor was vacuum-dried at 80°C for 1 hour, and 2000g L-lactide (L-lactide), 100g glycolide (glycolide) and 14g 1,2,6-hexanetriol were added under the protection of nitrogen In the reaction kettle, vacuum dry at 60° C. for 1 hour. Then 2g of stannous octoate was added, the temperature was increased to 140°C, and the reaction was maintained at 140°C for 3 hours to obtain a star-shaped PLGA prepolymer with a number average molecular weight of 20,000.

[0075] Synthesis of crosslinkable prepolymers:

[0076] Add 48g (0.32mol) of methacrylic anhydride and 0.6g (300ppm) of p-hydroxyanisole dropwise to the star-shaped PLGA prepolymer, and react at 150°C for 2 hours to form a cross-linkable star-shaped PLGA prepolymer After the reaction, the temperature was lowered to 60°C, 5L of ethyl acetate was ad...

Embodiment 2

[0082] Example 2: Degradable glass fiber reinforced cross-linked PDLGA composite material

[0083] Synthesis of degradable polymer prepolymers:

[0084] Before the polymerization, the reactor was vacuum-dried at 80° C. for 1 hour, and 1000 g of DL-lactide, 1000 g of glycolide and 61 g of 1,2,3-heptanetriol were mixed under nitrogen protection. Add it into the reaction kettle, and dry it under vacuum at 60° C. for 1 hour. Then 2g of stannous octoate was added, the temperature was increased to 160°C, and the reaction was maintained at 160°C for 3 hours to obtain a star-shaped PDLGA prepolymer with a number average molecular weight of 5000.

[0085] Synthesis of crosslinkable prepolymers:

[0086] Add 48g (0.32mol) of methacrylic anhydride and 0.6g (300ppm) of p-hydroxyanisole dropwise to the star-shaped PDLGA prepolymer, and react at 160°C for 2 hours to form a cross-linkable star-shaped PDLGA prepolymer After the reaction, the temperature was lowered to 60°C, 5L of ethyl ace...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Tensile strengthaaaaaaaaaa
Bending strengthaaaaaaaaaa
Tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a medical composite material and a preparing method thereof. The medical composite material comprises a base material and a degradable fiber material, wherein the base material is a cross-linking-type degradable polymer material which is of a three-dimensional network structure. The medical composite material has the mechanical strength higher than that of a linear high polymer material, and is easy to store, fracture can be avoided, and the requirements of high-strength medical devices can be met. In addition, the cross-linking-type polymer base material has the relative-low molecular weight and the simple and easy synthesis and preparing method and processing technology, and the technical problem that high-molecular-weight linear polymer is difficult in preparing and processing is solved.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a medical composite material and a preparation method thereof. Background technique [0002] Medical metal materials are the earliest biomaterials, because of their high strength and toughness, they are currently the most widely used in the repair of hard tissues. However, there are many problems in the treatment of patients with metal products, such as poor compatibility of metals, stress shielding effect, metal corrosion, and secondary surgical removal. It is because of these defects that biodegradable medical materials have emerged. [0003] The research on biodegradable polymers began in the 1960s, and is currently mainly used in surgical sutures, soft tissue implants, drug sustained release systems, hemostatic and anti-adhesion materials, orthopedic fixtures, and degradable vascular stents developed in recent years and other fields. [0004] Commercially available biodegrad...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08L67/04C08L97/02C08L5/08C08K7/14C08G63/08C08J3/24
Inventor 候娟汪璟姜洪焱康亚红罗七一
Owner 上海发微医用材料有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com