Medical composite material and preparing method thereof

A technology of composite materials and matrix materials, which is applied in the field of medical composite materials and their preparation, can solve the problems of not meeting the strength requirements of medical devices, lack of strength retention time, and reduced strength of composite materials, and achieve simple and easy synthesis and preparation methods and Processing technology, solve the difficulty of preparation and processing, and meet the effect of high strength

Active Publication Date: 2016-11-23
上海发微医用材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, due to the instability of the mechanical properties of the linear polymer material, the material degrades rapidly, or due to the hydrolysis of the fibers, the strength of the composite material decreases rapidly in a short period of time, and does not have sufficient strength retention time.
[0007] It can be see

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] The preparation method of the medical composite material provided by the present invention includes:

[0037] (1) Synthesize a biodegradable polymer prepolymer with two or more arms from monomers, initiators and catalysts

[0038] The monomers include, but are not limited to, glycolide, L-lactide, mixed-rotation lactide, ε-caprolactone, trimethylene carbonate, p-dioxanone, glycolic acid, salicylic acid Acids, carbonates, amino acids and their derivatives. In some embodiments, the copolymer is composed of two monomers, for example, the monomers are glycolide and levorotary lactide, and are mixed-rotary lactide and glycolide. There is no special requirement for the ratio between the monomers to prepare the copolymer. In some embodiments, the copolymer consists of two monomers in a weight ratio of 1:1-50:1, preferably 20:1.

[0039] Use different initiators (2 arms, 3 arms, 4 arms) to control the number of degradable polymer prepolymer arms. The initiators include, but are no...

Example Embodiment

[0072] Example 1: Degradable glass fiber reinforced cross-linked PLGA composite material

[0073] Synthesis of degradable polymer prepolymer:

[0074] Before polymerization, the reaction kettle was vacuum dried at 80°C for 1 hour, and 2000 g of L-lactide, 100 g of glycolide and 14 g of 1,2,6-hexanetriol were added under the protection of nitrogen. In the reaction kettle, vacuum drying was carried out at 60°C for 1 hour. Then, 2 g of stannous octoate was added, the temperature was increased to 140°C, and the reaction was maintained at 140°C for 3 hours to obtain a star-shaped PLGA prepolymer with a number average molecular weight of 20,000.

[0075] Synthesis of crosslinkable prepolymer:

[0076] Add 48g (0.32mol) of methacrylic anhydride and 0.6g (300ppm) of p-hydroxyanisole to the star-shaped PLGA prepolymer, and react at 150°C for 2 hours to form a crosslinkable star-shaped PLGA prepolymer After the reaction, the temperature is lowered to 60°C, 5L ethyl acetate is added to the rea...

Example Embodiment

[0082] Example 2: Degradable glass fiber reinforced cross-linked PDLGA composite material

[0083] Synthesis of degradable polymer prepolymer:

[0084] Before polymerization, the reaction kettle was vacuum dried at 80°C for 1 hour. Under the protection of nitrogen, 1000g of DL-lactide, 1000g of glycolide and 61g of 1,2,3-heptanetriol were added. Put it into the reaction kettle and vacuum dry at 60°C for 1 hour. Then 2g of stannous octoate was added, the temperature was increased to 160°C, and the reaction was maintained at 160°C for 3 hours to obtain a star-shaped PDLGA prepolymer with a number average molecular weight of 5000.

[0085] Synthesis of crosslinkable prepolymer:

[0086] Add 48g (0.32mol) of methacrylic anhydride and 0.6g (300ppm) of p-hydroxyanisole to the star-shaped PDLGA prepolymer, and react at 160℃ for 2 hours to form a crosslinkable star-shaped PDLGA prepolymer After the reaction, the temperature is lowered to 60°C, 5L ethyl acetate is added to the reaction kettl...

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PUM

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Abstract

The invention discloses a medical composite material and a preparing method thereof. The medical composite material comprises a base material and a degradable fiber material, wherein the base material is a cross-linking-type degradable polymer material which is of a three-dimensional network structure. The medical composite material has the mechanical strength higher than that of a linear high polymer material, and is easy to store, fracture can be avoided, and the requirements of high-strength medical devices can be met. In addition, the cross-linking-type polymer base material has the relative-low molecular weight and the simple and easy synthesis and preparing method and processing technology, and the technical problem that high-molecular-weight linear polymer is difficult in preparing and processing is solved.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a medical composite material and a preparation method thereof. Background technique [0002] Medical metal materials are the earliest biomaterials, because of their high strength and toughness, they are currently the most widely used in the repair of hard tissues. However, there are many problems in the treatment of patients with metal products, such as poor compatibility of metals, stress shielding effect, metal corrosion, and secondary surgical removal. It is because of these defects that biodegradable medical materials have emerged. [0003] The research on biodegradable polymers began in the 1960s, and is currently mainly used in surgical sutures, soft tissue implants, drug sustained release systems, hemostatic and anti-adhesion materials, orthopedic fixtures, and degradable vascular stents developed in recent years and other fields. [0004] Commercially available biodegrad...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08L97/02C08L5/08C08K7/14C08G63/08C08J3/24
Inventor 候娟汪璟姜洪焱康亚红罗七一
Owner 上海发微医用材料有限公司
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