17 results about "Spinal Meninges" patented technology

The invention discloses a mouse spinal cord flexible electrode and a stimulation parameter optimization method, and relates to the technical field of parameter optimization. The mouse spinal cord flexible electrode comprises a soluble insertion layer, a gradient substrate layer, spinal cord anastomosis ribs, a conductive snakelike net, a hemispherical touch dot matrix, a microfluidic layer, an optical waveguide layer and a top packaging layer; the soluble insertion layer is photo-crosslinked PEG-DMA with the thickness of 5-25 m, the Young modulus is kept within the range of 0.8-1.5 GPa before implantation, and the soluble insertion layer is hydrolyzed in cerebrospinal fluid within 0.5-3 hours after implantation and completely falls off; the spinal cord anastomosis rib comprises an expandable S-shaped folding structure arranged on the upper surface of the gradient substrate layer, the distance between every two adjacent ribs ranges from 80 m to 200 m, the height of the folded state is not larger than 15 m, the height of the unfolded state ranges from 15 m to 40 m, and the spinal cord anastomosis rib is used for forming a cerebro-spinalfluid bypass groove extending in the longitudinal direction of the spinal cord on the surface of the dura mater. According to the invention, the positioning precision, safety and long-term efficiency of mouse spinal cord electrical stimulation can be effectively improved.

The invention relates to a biological glue patch applied to non-invasive repair of dura mater, and relates to the technical field of medical biological materials. The biological glue patch comprises a patch base material, a biological membrane layer is arranged on one side of the patch base material, a hydrophobic membrane layer is arranged on the outer side of the biological membrane layer, a vacuum cavity is formed between the inner side of the biological membrane layer and the side portion of the patch base material, and biological glue is arranged in the vacuum cavity; one side, facing the biological membrane layer, of the patch base material is provided with a stabbing part for stabbing the biological membrane layer and the hydrophobic membrane layer. According to the biological glue patch, repairing of the dura mater is achieved in a glue adhesion mode, pinholes are avoided, the phenomenon of leakage of cerebrospinal fluid is avoided, meanwhile, the biological glue is protected through the biological film layer and the hydrophobic film layer, and the biological glue is prevented from being solidified and adhered in advance; the biological glue is released by arranging the stabbing part, the operation is simple, and the device can be applied to repairing the dural mater injury by a non-invasive single-side dual-channel spine endoscope technology.

The present application belongs to the technical field of medical devices, and relates to medical consumables for treating spinal cord injury, in particular to a double-layer core-shell structure artificial fiber dura mater for spinal cord injury and a preparation method thereof. The double-layer core-shell structure artificial fiber is used to form a film structure, the double-layer core-shell structure artificial fiber is composed of an outer shell structure and an inner core structure, the material of the outer shell structure is composed of PLGA and PEG, the outer shell structure is loaded with NM, the material of the inner core structure is PLA, and the inner core structure is loaded with NT3. The double-layer core-shell structure artificial fiber dura mater provided by the present application has the advantages of reducing spinal cord edema, preventing fiber adhesion, improving the microenvironment, promoting the repair of spinal cord injury, and the like.

The utility model discloses a spinal cord semi-cutting positioning device with a dura mater protection function, which comprises a semi-cutting positioning structure and a dura mater protection sheet, and is characterized in that the semi-cutting positioning structure comprises a mounting frame, a lifting driving module mounted on the mounting frame and a positioning guide pin mounted below a telescopic rod of the lifting driving module; the lifting driving module drives the positioning guide pin to lift; the dura mater protection sheet is in a lifting hook shape, an inner hook section and an outer arm section integrally connected with the inner hook section are formed, a depressed position of the inner hook section is a marrow containing groove so that the dura mater can be cut open, the dura mater protection sheet enables the inner hook section to stretch into an incision, after the spinal cord is placed in the marrow containing groove, the lifting driving module drives the positioning guide needle to descend, and then the dura mater is cut. The positioning guide needle is inserted into a central shaft of the spinal cord until the positioning guide needle abuts against the marrow containing groove. When the positioning guide needle punctures the spinal cord and the scalpel cuts down along the positioning guide needle, the dura mater can be protected by the dura mater protection sheet.

The utility model relates to a displacement reduction device for a fracture block in a spinal canal. The displacement reduction device comprises a holding part, a first connecting rod, a second connecting rod and a reduction part, the reduction part comprises a correction rod, a reduction rod and an epidural mater protection rod; the middle of the reset rod is an arc bent section, and two ends are linear sections. One surface of the correcting rod is connected with the end part of the second connecting rod; the linear section end part of one end of the resetting rod is connected with the correcting rod; the convex surface of the arc bent section of the reset rod faces the holding part; the end part of the linear section at the other end of the reset rod is connected with the dura mater protection rod; and the dura mater protection rod faces the direction of the holding part. The arc bent section of the reduction rod is more attached to an irregular fracture block, and meanwhile the correction rod can better support and stabilize the fracture block to be reduced in the operation process and prevent the fracture block from deviating and rolling. By arranging the dura mater protection rod on the reduction rod, when the fracture block is reduced, the compression of the spinal cord is directly relieved, the dura mater, the spinal cord and nerves can be prevented from being damaged, and iatrogenic secondary injury to a patient is avoided.

The invention relates to the field of medical auxiliary instruments, in particular to a spinal endoscopic dura mater retraction device which comprises a puncture component, and the puncture component is used for percutaneous puncture to the position close to a spinal canal dura mater; a suspension part is arranged in the puncture part, and the suspension part is used for extending out of the puncture part and being connected with the cut edge of the dura mater. An operation part is further arranged on the puncture part, and the operation part is used for adjusting the retraction force applied to the dural mater by the suspension part; by controlling the operation part, the suspension part is fixed and retracts the dura mater to expose the spinal cord tissue. Through the integration of puncture, suspension and operation components, the traction of the dura mater under the minimally invasive condition of the spine endoscope is realized.

The invention provides a method for extracting, purifying and identifying fibroblasts, which comprises the following steps of: cutting meninx or spinal membrane tissues into pieces, digesting, and centrifuging to obtain a precipitate; re-suspending the obtained precipitate by using a fibroblast culture solution, spreading the precipitate in a polylysine pre-coated culture flask, culturing until the cell confluence degree is 90%, shaking, and discarding the supernatant liquid to obtain purified fibroblasts; and carrying out passage on the obtained purified fibroblasts, carrying out immobilization and permeabilization, sealing with goat serum, sequentially adding a primary antibody solution and a fluorescent secondary antibody solution, dyeing with DAPI, and observing and identifying the fibroblasts under a fluorescence microscope to complete the extraction, purification and identification of the fibroblasts. The invention also provides an application of the method. The method is used for extracting, purifying and identifying meningeal fibroblasts or spinal fibroblasts. The fibroblasts extracted by the method are high in purity, short in culture period and simple to operate.

The utility model discloses a channel wire pusher, which comprises a rod part welded at one end of a handle part, claw-shaped pushing hand parts used for pushing wires are distributed at the top end of the rod part, an obtuse angle is formed between the rod part and the handle part, the included angle between every two claw-shaped pushing hand parts is 30 degrees, the included angle between the handle part and the rod part is 160 degrees, and the rod part is connected with the handle part. The number of the claw-shaped pushing hand parts is three, the length of each claw-shaped pushing hand part is 0.4 cm, the diameter of each claw-shaped pushing hand part is 0.2 cm, the length of each handle part is 4 cm, the diameter of each handle part is 1 cm, and the length of each rod part is 15 cm, and the diameter of each rod part is 0.3 cm. The device has the advantages of being small and exquisite, free of surgical view shielding, wide in application range, firm in knotting and the like, assists in dura mater suturing in the spinal microchannel surgery, reduces cerebrospinal fluid leakage after the surgery, and improves the working efficiency. And therefore, the novel medical infusion support disclosed by the utility model has a good use effect.

The invention provides a construction method of a spinal cord injury animal model for maintaining the integrity of subarachnoid space, which comprises the following steps: adopting a mammal with spinal cord injury, clamping and closing the opening of the dura mater of the mammal, dripping biological glue in alignment with the clamped and closed position, and suturing after the biological glue becomes frost and the dura mater is adhered together. The invention also provides application of the spinal cord injury animal model for maintaining the integrity of the subarachnoid space in research on motor function, nervous tissue recovery or tissue morphology recovery of animals after spinal cord injury. The application shows that after experimental spinal cord injury is caused, the motion function and histomorphological recovery of a mouse can be improved by tightly suturing the dura mater.

The application belongs to the technical field of biomedical experimental animal model construction, and provides a rat severe spinal cord injury immediate decompression model construction method. The method establishes a standardized surgical procedure, including minimally invasive exposure through the paraspinal muscle gap, precise dura mater incision, warm saline low-pressure lavage debridement, and strict dura mater suture repair. The method realizes immediate and effective reduction of intrathecal pressure, removal of harmful substances in the injury area, and stabilization of the local microenvironment after severe spinal cord injury. The application solves the problems of instability, poor repeatability, and difficulty in simulating the clinical decompression effect caused by the non-standard dura mater incision, uncontrollable lavage, and high risk of secondary injury in the prior art. The model constructed by the method is highly standardized and has strong repeatability, and is suitable for in-depth study of the neuroprotective mechanism of dura mater incision decompression treatment for spinal cord injury.

The utility model discloses an artificial ligamentum flavum complex which comprises an artificial ligament and two fixing seats, and the two ends of the artificial ligament are fixedly connected with the two fixing seats respectively. Screw holes are formed in the two fixing seats, the two fixing seats are fixedly connected with the spine by installing screws into the respective screw holes, and the bone contact surfaces at the bottoms of the two fixing seats are provided with micropore structures. When the artificial ligamentum flavum complex is installed on the spine, the artificial ligamentum flavum complex can replace the cut ligamentum flavum to maintain the mechanical stability of the spine and cover the dura mater to reduce postoperative dura mater scars. Therefore, the artificial ligamentum flavum complex can replace ligamentum flavum removed in the operation, improve the stability of the spine of a patient, reduce postoperative spine instability, protect spinal canal duramater and nerves, reduce scar adhesion and improve the postoperative clinical effect.

The application relates to a biological glue patch applied to noninvasive repair of a dura mater, and relates to the technical field of medical biomaterials. The biological glue patch comprises a patch base material, one side of the patch base material is provided with a biological membrane layer, the outer side of the biological membrane layer is provided with a hydrophobic membrane layer, a vacuum cavity is formed between the inner side of the biological membrane layer and the side of the patch base material, and biological glue is arranged in the vacuum cavity; and the side of the patch base material facing the biological membrane layer is provided with a piercing part for piercing the biological membrane layer and the hydrophobic membrane layer. The biological glue patch in the application realizes repair of the dura mater in a glue adhesion mode, needle holes do not occur, the phenomenon of cerebrospinal fluid leakage is avoided, meanwhile, the biological membrane layer and the hydrophobic membrane layer protect the biological glue, and prevent the biological glue from being prematurely solidified and bonded; the piercing part is arranged to release the biological glue, the operation is simple, and the biological glue patch can be applied to noninvasive unilateral double-channel endoscopic spinal surgery for repairing dura mater injury.

The application belongs to the technical field of biomedical materials, and particularly relates to an in-vitro spinal cord-like model based on nanofilament yarns and a preparation method and application thereof. The in-vitro spinal cord-like model based on nanofilament yarns is designed and prepared, and has the characteristics of precise anatomical positioning, reasonable cell spatial distribution and the like. In the application, nanofilament yarns are used as inner cores, and nanofiber tubes are used as outer sheaths. On the one hand, the nanofilament yarns that play the role of nerve-like conducting bundles guide the oriented arrangement of NSPCs and promote the directional differentiation of the NSPCs. On the other hand, the nanofiber tubes play the role of artificial dura mater, prevent epidural adhesion and provide a stable intraluminal microenvironment for nerve regeneration. Finally, the nanofilament yarns carry model drugs to realize batch screening of the drugs in the spinal cord-like model.

The invention belongs to the technical field of biomedical materials, and discloses preparation of a low-swelling medical tissue sealant and application of the low-swelling medical tissue sealant in dura mater repair. The invention discloses a sealant. The sealant is prepared from the following raw materials: multi-arm polyethylene glycol active ester and aminated gelatin. The invention provides a sealant. The sealant is formed by crosslinking multi-arm polyethylene glycol active ester and aminated gelatin through amido bonds. The sealant has the advantages of rapid gelling, high mechanical strength, strong tissue adhesion, ultralow swelling ratio, controllable degradation and excellent biocompatibility. The sealant can realize in-situ sealing and repairing of dura mater injury and prevent leakage of cerebrospinal fluid, has antibacterial, anti-infection and nerve protection effects, is suitable for repairing of dura mater and dura mater, and is especially suitable for minimally invasive neurosurgery.

The application relates to the technical field of medical devices, and discloses an ultrasound-guided pressure monitoring epidural anesthesia positioning device, which comprises a placing shell, an upper tray and a lower tray arranged in the placing shell, and a puncture component comprising an ultrasound positioning epidural puncture needle assembly and a puncture sensor assembly, wherein the ultrasound positioning epidural puncture needle assembly comprises a puncture needle seat. The ultrasound-guided pressure monitoring epidural anesthesia positioning device can accurately determine the position of a needle tip, effectively avoid complications such as rupture of the spinal cord, blood vessel injury and nerve injury caused by blind puncture, significantly improve anesthesia safety, and clearly display anatomical structures such as ligaments and the spinal cord through ultrasound guidance. The ultrasound-guided pressure monitoring epidural anesthesia positioning device can significantly improve the puncture success rate for obese, patients with spinal deformity and old patients who are difficult to puncture in a traditional way. Meanwhile, the puncture pressure sensor can continuously monitor and display the pressure change curve in the puncture process, provide objective and quantitative judgment basis, and reduce the dependence on the subjective experience of an operator.

The application discloses a spinal cord hemisection device and a hemisection method for manufacturing an animal spinal cord injury model. The spinal cord hemisection device comprises a spinal cord hemisection device main body and a master control center. The master control center is arranged outside the spinal cord hemisection device main body and is used for controlling the action of the spinal cord hemisection device main body. The spinal cord hemisection device main body comprises a fixing frame, a hemisection driving mechanism, a spinal cord fixing structure and a cutting assembly. The hemisection driving mechanism is arranged on the fixing frame. The cutting assembly is installed on the hemisection driving mechanism in a lifting manner. After the fixing frame is arranged above a non-human primate to be modeled and a surgical incision of a dura mater is manually opened, the spinal cord fixing structure penetrates into the gap between the spinal cord and the dura mater, surrounds the outer periphery of the spinal cord, the hemisection driving mechanism is located above the incision and drives the cutting assembly to act, and the spinal cord fixing structure performs spinal cord hemisection. The application does not damage too much dura mater and is convenient for postoperative maintenance.

1. The name of the design product: needle for anesthesia (lumbar puncture needle). 2. The use of the design product: for human epidural nerve block (epidural anesthesia), subarachnoid block (lumbar anesthesia), epidural and lumbar combined anesthesia, nerve block local anesthesia. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: assembly state diagram.