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35 results about "Adhesion factor" patented technology

Factor of adhesion. In railroad engineering, the factor of adhesion of a locomotive is the weight on the driving wheels divided by the starting tractive effort. A common rule is that for a steam locomotive a good factor of adhesion equals or exceeds 4, but not by too much.

Vehicle curve safety vehicle speed predication and pre-warning system based on multiple regression analysis

The invention relates to a vehicle curve safety vehicle speed predication and pre-warning system based on multiple regression analysis. The vehicle curve safety vehicle speed predication and pre-warning system based on the multiple regression analysis comprises a test data collection module, a test data pre-processing module, a test data analysis module, a safety vehicle speed model database, a curve information module, a vehicle type judging module and a curve safety vehicle speed pre-warning module. According to the vehicle curve safety vehicle speed predication and pre-warning system basedon the multiple regression analysis, desired test data are collected, multiple linear regression analysis is carried out on processed test data to obtain a critical transverse adhesion factor model and a transverse load transfer rate model, and the critical transverse adhesion factor model and the transverse load transfer rate model are converted by using a formula to obtain a safety vehicle speedmodel. Collected curve pavement data and vehicle types are input into the safety vehicle speed model database. A curve safety predicated vehicle speed is obtained after calculation and displayed on an LED display screen at the entrance of a curve to warn a driver of a curve safety passing vehicle speed. According to the vehicle curve safety vehicle speed predication and pre-warning system based on the multiple regression analysis, the influences of multiple factors on the curve safety vehicle speed are comprehensively considered, and the curve safety vehicle speed can be accurately predicatedto provide a safety pre-warning vehicle speed for the driver so that the vehicle stably and safely runs through the curve.
Owner:JILIN UNIV

Atomic force microscope probe and probe tip thereof and method for detecting capability of adhesion between helicobacter pylori and gastric mucus

InactiveCN102621352AConvenient researchResearch on Facilitation InteractionsScanning probe microscopyAtomic force microscopyGold particles
Provided in the invention is a tip of an atomic force microscope probe. The probe tip is characterized in that: the tip comprises: a helicobacter pylori; a gold particle layer covered on the outer surface of the helicobacter pylori; and a helicobacter pylori adhesion factor modified on the outer surface of the gold particle layer. Besides, the invention also provides an atomic force microscope probe including the tip as well as a method for detecting capability of adhesion between helicobacter pylori and gastric mucus. According to the invention, on the basis of atomic force microscopy (AFM), a condition of contact between helicobacter pylori and gastric mucus in a natural state is substantially simulated by utilizing characteristics of high precision and real-time observation of the AFM, so that it becomes possible to carry out on-site research on a submicron acting force between an adhesion factor and the gastric mucus in the scale of micron meters; and mechanical information that is obtained by utilizing a force curve is converted into adhesive work according to a formula, thereby carrying out accurate quantification on the capability of adhesion between the adhesion factor on the surface of the helicobacter pylori and the gastric mucus.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

TNF alpha and DC-SIGN fusion protein and application thereof

The invention relates to a TNF alpha and DC-SIGN fusion protein and an application thereof. In a traditional anti-tumor medicament or a treatment method, normal cells are easy to damage in the process of killing tumor cells. The targeting anti-tumor fusion protein provided by the invention comprises an identification functional domain and an action functional domain, as well as a connecting peptide for connecting the two functional domains. The identification functional domain is as follows: a lectin polypeptide with tumor cell surface sugar chain identification and combination functions-a DC surface specific intercellular adhesion factor 3 combined with non-integrin molecules (DC-SIGN, dendritic-cell-specific ICAM-3-grabbing nonintegrin) is positioned at a C terminal of the fusion protein; the action functional domain is as follows: a tumor necrosis factor (TNF) is positioned at an N terminal of the fusion protein; and the connecting peptide is a short peptide containing 8-25 amino acids. The fusion protein can utilize lectin and cancer cells to perform targeting combination, induce the apoptosis of the cancer cells through a ligand capable of promoting the apoptosis of the cells and simultaneously reduce the killing effect against normal tissues and cells.
Owner:ZONHON BIOPHARMA INST

A kind of helicobacter pylori tetravalent adhesion factor multi-epitope vaccine and preparation method thereof

ActiveCN105126093BBiological toxicity avoidanceProtect against immunopathological damageAntibacterial agentsPeptide preparation methodsEscherichia coliDisease
The invention provides a multi-epitope vaccine for a helicobacter pylori tetravalent adhesion, wherein the activity of the multi-epitope vaccine is presented as a polypeptide which mainly consists of urease A and B subunits, superior Th and B cell epitopes or fragments of three outer membrane proteins (Lpp20, HpaA and CagL) as well as cholera toxin B subunit. According to the invention, an artificial gene is synthesized by virtue of gene synthesis technology, wherein the synthesized artificial gene consists of urease A and B subunits, and superior Th and B cell epitopes or fragments of three outer membrane proteins (Lpp20, HpaA and CagL), and the artificial gene is coupled with gene sequence of the cholera toxin B subunit, so as to form a fusion gene. The fusion gene is expressed by escherichia coli, and upon protein purification, the tetravalent adhesion multi-epitope vaccine is obtained. The vaccine can be used for inducing a body to generate T cellullar immunologic response and specific antibody humoral immune response in accordance with the urease A and B subunits and the three outer membrane proteins (Lpp20, HpaA and CagL); and the vaccine is suitable for preventing and controlling helicobacter pylori infection related diseases.
Owner:NINGXIA MEDICAL UNIV

Prediction and early warning system of safe vehicle speed in curves based on multiple regression analysis

The invention relates to a vehicle curve safety vehicle speed predication and pre-warning system based on multiple regression analysis. The vehicle curve safety vehicle speed predication and pre-warning system based on the multiple regression analysis comprises a test data collection module, a test data pre-processing module, a test data analysis module, a safety vehicle speed model database, a curve information module, a vehicle type judging module and a curve safety vehicle speed pre-warning module. According to the vehicle curve safety vehicle speed predication and pre-warning system basedon the multiple regression analysis, desired test data are collected, multiple linear regression analysis is carried out on processed test data to obtain a critical transverse adhesion factor model and a transverse load transfer rate model, and the critical transverse adhesion factor model and the transverse load transfer rate model are converted by using a formula to obtain a safety vehicle speedmodel. Collected curve pavement data and vehicle types are input into the safety vehicle speed model database. A curve safety predicated vehicle speed is obtained after calculation and displayed on an LED display screen at the entrance of a curve to warn a driver of a curve safety passing vehicle speed. According to the vehicle curve safety vehicle speed predication and pre-warning system based on the multiple regression analysis, the influences of multiple factors on the curve safety vehicle speed are comprehensively considered, and the curve safety vehicle speed can be accurately predicatedto provide a safety pre-warning vehicle speed for the driver so that the vehicle stably and safely runs through the curve.
Owner:JILIN UNIV

Atomic force microscope probe and probe tip thereof and method for detecting capability of adhesion between helicobacter pylori and gastric mucus

InactiveCN102621352BConvenient researchResearch on Facilitation InteractionsScanning probe microscopyGold particlesHelicobacter pylori
Provided in the invention is a tip of an atomic force microscope probe. The probe tip is characterized in that: the tip comprises: a helicobacter pylori; a gold particle layer covered on the outer surface of the helicobacter pylori; and a helicobacter pylori adhesion factor modified on the outer surface of the gold particle layer. Besides, the invention also provides an atomic force microscope probe including the tip as well as a method for detecting capability of adhesion between helicobacter pylori and gastric mucus. According to the invention, on the basis of atomic force microscopy (AFM), a condition of contact between helicobacter pylori and gastric mucus in a natural state is substantially simulated by utilizing characteristics of high precision and real-time observation of the AFM, so that it becomes possible to carry out on-site research on a submicron acting force between an adhesion factor and the gastric mucus in the scale of micron meters; and mechanical information that is obtained by utilizing a force curve is converted into adhesive work according to a formula, thereby carrying out accurate quantification on the capability of adhesion between the adhesion factor on the surface of the helicobacter pylori and the gastric mucus.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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