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Composite biological patch as well as preparation method and application thereof

A biological patch and drug technology, applied in the medical field, can solve the problems of poor adherence, no pore structure, unsatisfactory mechanical properties, etc., and achieve the effects of low cost and simple and convenient preparation method.

Active Publication Date: 2021-11-19
BEIJING BONSCI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current biological patch has the following disadvantages: ①The general mechanical properties are not ideal. In order to ensure the mechanical strength of the patch, chemical cross-linking is often used for modification, which is prone to solvent residues and cannot guarantee the biocompatibility of the patch. and safety; ③ Directly use animal tissue for repair after treatment, such as pigskin, pericardium, etc., which have poor adherence and are prone to deviation; ④ Does not have a suitable pore structure, so it does not have good tissue regeneration

Method used

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  • Composite biological patch as well as preparation method and application thereof
  • Composite biological patch as well as preparation method and application thereof
  • Composite biological patch as well as preparation method and application thereof

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preparation example Construction

[0079] In some preferred embodiments, the preparation method of the hydrophobic porous layer comprises the following steps:

[0080] Dissolve hydrophobic nanocellulose in organic reagents, then add anti-infective drugs, mix and form a film;

[0081] Preferably, the organic reagent includes but not limited to hexafluoroisopropanol and / or ethanol;

[0082] Preferably, the ratio of the hydrophobic nanocellulose to the organic reagent is 1g:(4-8)mL, such as, but not limited to, 1g:4mL, 1g:5mL, 1g:6mL, 1g:7mL or 1g: 8mL;

[0083] Preferably, in terms of mass percentage, the added amount of the anti-infective drug is 5%-10% of the hydrophobic nanocellulose, such as, but not limited to, 5%, 6%, 7%, 8%, 9% or 10%;

[0084] Preferably, the film-making method includes but is not limited to electrospinning, or other film-making methods well known to those skilled in the art;

[0085] Preferably, the hydrophobic porous layer has a thickness of 0.5-2 mm, for example, but not limited to...

Embodiment 1

[0140] A composite biological patch, its preparation method is as follows:

[0141] 1. Preparation of hydrophobic porous layer: Take a certain amount of ethyl cellulose and dissolve it in hexafluoroisopropanol solvent, the addition ratio is 1g:6mL, stir for 36 hours to prepare a spinning solution with a concentration of 9.5%, and then add anti The infection drug ketoprofen was added in a proportion of 8% of the ethyl cellulose, and then the stirring was continued for 60 hours to obtain a spinning solution containing an anti-infection drug. Put the spinning liquid into the syringe, connect the needle to high voltage, the receiving device is aluminum foil, the spinning voltage is 15kV, the spinning rate is 0.3mL / h, the receiving distance is 15cm, the spinning time is 3h, and the fiber with a thickness of 1mm is obtained Then the obtained nanofiber membrane was dried in a vacuum oven at 80° C. overnight to remove residual solvent.

[0142] 2. Preparation of type Ⅰ collagen porou...

Embodiment 2

[0152]A composite biological patch, its preparation method is as follows:

[0153] 1. Preparation of the hydrophobic porous layer: Take a certain amount of ethyl cellulose and dissolve it in the solvent absolute ethanol, the addition ratio is 1g:4mL, stir for 24-48h and prepare a spinning solution with a concentration of 24.1%, and then add anti The infection drug ketoprofen was added in a proportion of 5% of the ethyl cellulose, and then the stirring was continued for 48 hours to obtain a spinning solution containing an anti-infection drug. Put the spinning solution into the syringe, connect the needle to high voltage, the receiving device is aluminum foil, the spinning voltage is 10kV, the spinning rate is 0.1mL / h, the receiving distance is 13cm, the spinning time is 1h, and the thickness is 0.5mm. Cellulose nanofiber membrane, and then place the obtained nanofiber membrane in a vacuum oven at 80° C. to dry overnight to remove residual solvent.

[0154] 2. Preparation of ty...

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Abstract

The invention provides a composite biological patch as well as a preparation method and an application thereof, and relates to the technical field of medical treatment. The composite biological patch provided by the invention comprises a hydrophobic porous layer, a compact layer and a porous scaffold, the hydrophobic porous layer is opposite to one side of a to-be-repaired tissue and is loaded with an anti-infection drug, the hydrophobicity of the hydrophobic porous layer and the loaded drug can be matched with each other, the drug can be slowly released, and the effects of prevention, anti-infection and anti-adhesion are achieved; the porous scaffold has a porous structure, faces one side of a to-be-repaired tissue, is beneficial to adhesion and growth of cells, and induces membrane tissue regeneration; the hydrophobic porous layer and the porous scaffold spacing compact layer can ensure the dimensional stability and mechanical strength of the product, and also can play a role of a barrier. The composite biological patch provided by the invention can be used for meninx repair, spinal meninx repair, rotator cuff repair, hernia repair, ophthalmology repair, breast repair, hemostasis repair or oral cavity repair.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a composite biological patch and its preparation method and application. Background technique [0002] The repair and regeneration of human defective tissue has always been a clinical problem. In recent years, with the continuous development of cell biology and tissue engineering technology, a new repair material - biological patch has gradually attracted people's attention. Biological patch refers to the material derived from the same or heterogeneous biological tissue, which removes all kinds of cells contained in the tissue through decellularization and other processes, and completely preserves the three-dimensional structure of the extracellular matrix and can be used to repair damaged soft tissues of the human body. . Biological patch can repair damaged tissue through space induction and tissue replacement, and has good tissue compatibility. Collagen belongs to an extrac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/20A61L27/24
CPCA61L27/56A61L27/54A61L27/50A61L27/20A61L27/24A61L2430/12A61L2430/16A61L2430/04A61L2430/32A61L2430/30A61L2430/10A61L2400/04A61L2300/404A61L2300/602A61L2300/236A61L2300/41A61L2430/40C08L1/284C08L1/16
Inventor 聂洪涛张凯王璇
Owner BEIJING BONSCI TECH CO LTD
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